The purpose of this study is to understand how liverdisease affects thinking and memory, both before and after transplant. Participants will take a cognitive test, which will be a series of tasks and questions similar to a video game, at home on their own computers, tablets, or phones. This will…
The main purpose of this study is to deeply characterize cognitive function in liver transplant recipients, differentiate among different causes of cognitive impairment, and identify contributors to cognitive impairment. Participants will receive a comprehensive neurological exam, cognitive assessment, neuropsychological…
The purpose of this study is to learn more about the effects of functional status (also known as "frailty") using a physical test in patients with liverdisease on their health outcomes. We are enrolling patients prior to liver transplantation, and will continue to…
The purpose of this observational research study is to identify things that contribute to outcomes in patients with alcohol-associated liverdisease who are being considered for liver transplant and who have less than 6 months of sobriety. We will look at many…
This is a prospective, randomized, multi-center, controlled study for subjects with end stage liverdisease who require a liver transplant, comparing whole liver preservation via hypothermic machine perfusion (HMP) using the LLT System…
The purpose of this study is to evaluate the safety of siplizumab when used as induction immunosuppression in patients with primary sclerosing cholangitis or autoimmune hepatitis undergoing liver transplantation. Induction immunosuppression drugs are very potent anti-rejection drugs that are given immediately after…
The primary objective of this study is to determine if an HIV-infected donor liver (HIVD+) transplant is safe with regards to major transplant-related and HIV-related complications. This study will evaluate if receiving a liver transplant from an HIV-infected deceased …
The primary objective is to evaluate long-term outcomes in transplant recipients with HIV who receive livers from donors with HIV compared to donors without HIV. If you have any questions regarding this study, please contact the Transplant Clinical Research Center (TCRC).
This study is looking at hepatitis B virus (HBV) vaccination in adults 18 to 70 years of age living with HIV around the world. Hepatitis B is a serious viral infection that affects the liver and is transmitted through blood and body fluids. A vaccine (a shot of medicine given through a needle) can prevent HBV, but there is no…