The purpose of this study is to understand how liverdisease affects thinking and memory, both before and after transplant. Participants will take a cognitive test, which will be a series of tasks and questions similar to a video game, at home on their own computers, tablets, or phones. This will…
The main purpose of this study is to deeply characterize cognitive function in liver transplant recipients, differentiate among different causes of cognitive impairment, and identify contributors to cognitive impairment. Participants will receive a comprehensive neurological exam, cognitive assessment, neuropsychological…
The purpose of this study is to learn more about the effects of functional status (also known as "frailty") using a physical test in patients with liverdisease on their health outcomes. We are enrolling patients prior to liver transplantation, and will continue to…
The purpose of this observational research study is to identify things that contribute to outcomes in patients with alcohol-associated liverdisease who are being considered for liver transplant and who have less than 6 months of sobriety. We will look at many…
This is a prospective, randomized, multi-center, controlled study for subjects with end stage liverdisease who require a liver transplant, comparing whole liver preservation via hypothermic machine perfusion (HMP) using the LLT System…
The purpose of this study is to evaluate the safety of siplizumab when used as induction immunosuppression in patients with primary sclerosing cholangitis or autoimmune hepatitis undergoing liver transplantation. Induction immunosuppression drugs are very potent anti-rejection drugs that are given immediately after…
This study is for patients with autosomal dominant polycystic kidney disease (ADPKD). The purpose of this study is to test the effectiveness of a study drug called tolvaptan. Tolvaptan continues to be studied in this trial as a possible treatment for ADPKD. ADPKD is a disease that causes kidney…