The purpose of this study is to understand how liverdisease affects thinking and memory, both before and after transplant. Participants will take a cognitive test, which will be a series of tasks and questions similar to a video game, at home on their own computers, tablets, or phones. This will…
The main purpose of this study is to deeply characterize cognitive function in liver transplant recipients, differentiate among different causes of cognitive impairment, and identify contributors to cognitive impairment. Participants will receive a comprehensive neurological exam, cognitive assessment, neuropsychological…
The purpose of this study is to learn more about the effects of functional status (also known as "frailty") using a physical test in patients with liverdisease on their health outcomes. We are enrolling patients prior to liver transplantation, and will continue to…
The purpose of this observational research study is to identify things that contribute to outcomes in patients with alcohol-associated liverdisease who are being considered for liver transplant and who have less than 6 months of sobriety. We will look at many…
This is a prospective, randomized, multi-center, controlled study for subjects with end stage liverdisease who require a liver transplant, comparing whole liver preservation via hypothermic machine perfusion (HMP) using the LLT System…
The purpose of this study is to evaluate the safety of siplizumab when used as induction immunosuppression in patients with primary sclerosing cholangitis or autoimmune hepatitis undergoing liver transplantation. Induction immunosuppression drugs are very potent anti-rejection drugs that are given immediately after…
Women will be enrolled at or prior to prenatal visit at 34-40 weeks gestation with follow-up visits within 48 hours of delivery, and 6 and 12 months postpartum among the mother and infant. Maternal and infant measurements will be conducted at each visit. The purpose of the study is to estimate cardiovascular…