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Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature (ELEGANCE)

Condition: Heart Disease / Peripheral Arterial Disease

Status: Currently Recruiting

This study aims to collect information about the symptoms and treatments of patients who have severely clogged arteries and are treated with commercially available Boston Scientific Corporation drug-eluting devices marketed for the treatment of lesions located in the peripheral vasculature. Participation in the study is expected to last for up to two (2)…

Study of NBTRX3 in Patients with Head & Neck Squamous Cell Carcinoma (HNSCC)

Condition: Cancer / Head and Neck Cancer

Investigator: Brian Henick, MD

Status: Closed

The purpose of this research study is to evaluate the safety and effectiveness (how well the study drug works) of NBTRX3 administered via intratumoral injections (injected directly into tumor) and used together with radiotherapy or radiotherapy combined with cetuximab, and how it compares with radiotherapy alone, or radiotherapy combined with cetuximab.…

Observational Study to Assess Transradial Access for Treatment in the Lower Extremities (R2P Registry)

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sanjum Sethi, MD, MPH

Status: Closed

This is a prospective, multi-center, observational, post-market study that will evaluate the safety and procedural success of performing trans-radial access for treatment of atherosclerotic lesions in the lower extremities. This research study will collect outcome data of patients undergoing percutaneous endovascular treatment of Peripheral Artery Disease (…

Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA

Condition: Cancer / Head and Neck Cancer

Investigator: Matthen Mathew, MD

Status: Closed

There are two study questions we are asking in this randomized phase II/III trial based on a blood biomarker, Epstein Barr virus (EBV) deoxyribonucleic acid (DNA) for locoregionally advanced non-metastatic nasopharyngeal cancer. All patients will first undergo standard concurrent chemotherapy and radiation therapy. When this standard treatment is completed…

A study to assess the documentation of Hepatic Encephalopathy in clinical practice

Condition: Liver Disease / Hepatic Encephalopathy

Investigator: Robert Brown, MD, MPH

Status: Closed

The purpose of this study is to find out how doctors describe hepatic encephalopathy episodes in patients medical records in the course of their regular practice. The aim of the study is simply to collect information from their medical records about how their episodes of overt hepatic encephalopathy are described. There is nothing that will be required of…

A study of the safety and effectiveness of a new drug coated balloon in blockages above the knee.

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sahil Parikh, MD

Status: Closed

The purpose of this study is to deterimine if the Drug-Coated Chocolate Touch Balloon Catheters is safe and effective compared to a drug-coated balloon that is already approved in patients with a blockage in the blood vessels of their leg.

Study for patients with with hepatic encephalopathy using drug, rifaximin

Condition: Liver Disease / Hepatic Encephalopathy

Investigator: Robert Brown, MD, MPH

Status: Closed

The purpose of this study is to compare the time to onset of an episode of overt HE, in subjects with previously demonstrated overt HE after treatment with rifaximin 550 mg BID and lactulose, or rifaximin 550 mg BID. Subjects will be screened to confirm eligibility into the study. Once confirmed, subjects will begin the treatment phase and will be randomly…

Comparison of a device that delivers sonic energy (sound) versus standard balloon to disrupt hard, calcified vascular blockages

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sahil Parikh, MD

Status: Closed

This study is for patients who suffer from a condition where one of the blood vessels that deliver blood to your leg has a significant narrowing. This is called peripheral artery disease (PAD). The narrowing may be suitable for a treatment technique called balloon angioplasty. One of the therapies that has been used to treat PAD is balloon angioplasty. It…

A study for patients with Melanoma, Squamous Cell Cancer of the Head and Neck, or Non-Small Cell Lung cancer using study drug MGA271

Condition: Cancer / Head and Neck Cancer

Investigator: Richard Carvajal, MD

Status: Closed

The study involves research about MGA271 in combination with Keytruda. MGA271 targets cancer cells that make a lot of a protein called B7-H3. Another way to say it is that the cells "overexpress" the protein. Very few normal cells express B7-H3. MGA271 is though to work by recognizing cancer cells that overexpress B7-H3 and directing the body…

SCOPE CLI: Shifting Care and Outcomes for Patients With Endangered Limbs - Critical Limb Ischemia

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sahil Parikh, MD

Status: Closed

This study is to collect information about the symptoms and treatments of patient who have severely clogged arteries and to learn about their outcomes at one year. If you choose to be part of this research, we will ask you to be involved in five interviews with study staff. Each interview will take about 30 minutes of your time and we will contact you…

Study of ADU-S100 and Pembrolizumab in Head and Neck Cancer

Condition: Cancer / Head and Neck Cancer

Investigator: Matthen Mathew, MD

Status: Closed

The purpose of this study is to study ADU-S100 and pembrolizumab in patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC). This study aims to evaluate how safe and effective this drug combination is at treating your cancer. These drugs are thought to work by interacting with your immune system to in order to more effectively…

TAP-DANCE: Temsirolimus Alone or Paired with Dexamethasone After Femoropopliteal Revascularization (Femoral Artery Disease Procedure)

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sahil Parikh, MD

Status: Closed

This study is to test if a combination drug/device therapy using TEMSIROLIMUS (Temsirolimus Injection), with or without the generic steroid DEXAMETHASONE (Dexamethasone Sodium Phosphate Injection), can be delivered safely into the tissue around the blood vessel wall at the time of an angioplasty ( which is a a procedure to open blocked arteries and restore…

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