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Lowering Insulin to Decrease Liver Fat Production

Condition: Nutrition

Status: Currently Recruiting

We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, ages 18-65, who have obesity with a body mass index of 30-45, and have been diagnosed with, or are at risk for, prediabetes and metabolic…

Echopulse for Treatment of Breast Fibroadenomas in Women

Condition: Surgery

Investigator: Bret Taback, MD

Status: Closed

The purpose of this study is to test an investigational device called the Echopulse for treatment of breast fibroadenomas in women. Fibroadenomas are benign (noncancerous) breast tumors. These lumps can occur alone, in groups, or as a complex of lumps together. Sometimes women feel these in the breast when doing regular self-breast exams, or they may be…

Study of NBTRX3 in Patients with Head & Neck Squamous Cell Carcinoma (HNSCC)

Condition: Cancer / Head and Neck Cancer

Investigator: Brian Henick, MD

Status: Closed

The purpose of this research study is to evaluate the safety and effectiveness (how well the study drug works) of NBTRX3 administered via intratumoral injections (injected directly into tumor) and used together with radiotherapy or radiotherapy combined with cetuximab, and how it compares with radiotherapy alone, or radiotherapy combined with cetuximab.…

Investigating Problem Solving in Health Management

Condition: Nutrition

Investigator: Lena Mamykina, PhD

Status: Closed

We are conducting an academic study to understand how people solve problems related to health. In the study, participants will be presented with a hypothetical problem related to diabetes self-management and asked to use an online health application to explore information and propose a solution. We invite all participants between 18 and 65 years old, who…

Chatbot for Nutritional Coaching and Chronic Disease Self-Management

Condition: Nutrition

Investigator: Lena Mamykina, PhD

Status: Closed

Seeking participants for a study about how individuals prefer to receive nutrition recommendations to support health management and preferences for visualizing health data. Participants will be invited to complete a 60-minute session to answer questionnaires and evaluate different styles of nutrition recommendations. Alternatively, they will complete one 60…

Meal Choices Study

Condition: Nutrition

Investigator: Lena Mamykina, PhD

Status: Closed

Study to Reduce Lung Complications in Patients Undergoing Open Abdominal Surgery The PrimeAir Study

Condition: Surgery

Investigator: Marcos Vidal Melo, MD, PhD

Status: Closed

We are asking you to participate in a research study to learn if different ways of doing routine anesthesia and patient care before, during and after abdominal surgery can reduce breathing problems. The total time of the study is 3 months with daily visits by a member of our study team while you are in the hospital and 3 short follow-up calls after you…

Study of ADU-S100 and Pembrolizumab in Head and Neck Cancer

Condition: Cancer / Head and Neck Cancer

Investigator: Matthen Mathew, MD

Status: Closed

The purpose of this study is to study ADU-S100 and pembrolizumab in patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC). This study aims to evaluate how safe and effective this drug combination is at treating your cancer. These drugs are thought to work by interacting with your immune system to in order to more effectively…

The Anti-Inflammatory Effects of Exercise and Peanut Consumption

Condition: Nutrition

Investigator: Richard Sloan, PhD

Status: Closed

We will enroll and randomly assign 30 sedentary, healthy overweight men and women to two groups. Participants will either start by consuming peanuts for 4 weeks, and then go on to exercise at high intensity intervals (HIIT) for 4 weeks, or the reverse order. We will test and compare the effect of peanuts and exercise on inflammation and heart rate…

Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA

Condition: Cancer / Head and Neck Cancer

Investigator: Matthen Mathew, MD

Status: Closed

There are two study questions we are asking in this randomized phase II/III trial based on a blood biomarker, Epstein Barr virus (EBV) deoxyribonucleic acid (DNA) for locoregionally advanced non-metastatic nasopharyngeal cancer. All patients will first undergo standard concurrent chemotherapy and radiation therapy. When this standard treatment is completed…

A study assessing the study device, InSpace device, for treatment of massive rotator cuff tears

Condition: Surgery

Investigator: William Levine, MD

Status: Closed

The study is designed to evaluate the safety and effectiveness of the InSpace device as a primary surgical treatment for a full thickness Massive Rotator Cuff Tears (MRCT) in comparison to Partial Repair of a full thickness MRCT performed during an arthroscopic procedure.

A study for patients with Peripheral Artery Disease (PAD) using two of two drug-eluting stents

Condition: Surgery

Investigator: Danielle Bajakian, MD

Status: Closed

The purpose of this research study is to compare the safety and effectiveness of two drug-eluting stents that are used to open the blocked or narrowed blood vessel of the leg in patients with Peripheral Artery Disease (PAD): the ELUVIA Stent and the Zilver PTX Stent.

A study for adults with Obstructive Sleep Apnea using a CPAP machine to view its effects on diet, physical activity and cardiovascular risk

Condition: Nutrition

Investigator: Ari Shechter, PhD

Status: Closed

We are currently looking for overweight (body mass index 25 kg/m2) men and women, age 18-65 y, to participate in a sleep study. To participate you must have been diagnosed with Obstructive Sleep Apnea within the past year, and have been prescribed continuous positive airway pressure (CPAP) but not have not yet started treatment. This is a 2-phase,…

A study for patients who have had Cardiac surgery using study drug QPI-1002

Condition: Surgery

Investigator: Michael Argenziano, MD, FACS

Status: Closed

Thepurposeof the study is to test whether or not QPI-1002 could be used to lessen or prevent acute kidney injury after heart surgery. Another purpose is to better understand the safety of QPI-1002.

A study for adults with degenerative joint disease of the knee requiring total knee replacement using the Journey II CR Total Knee System

Condition: Surgery

Investigator: Jeffrey Geller, MD

Status: Closed

The purpose of this study is to evaluate the short-term (1 year) and long-term (5 and 10 year) safetyand effectiveness of the JOURNEY II CR Total Knee System in patients with degenerative joint disease of the knee requiring primary total knee replacement. Clinical, radiographic, and health economic outcomes will be evaluated.

A study for patients with Melanoma, Squamous Cell Cancer of the Head and Neck, or Non-Small Cell Lung cancer using study drug MGA271

Condition: Cancer / Head and Neck Cancer

Investigator: Richard Carvajal, MD

Status: Closed

The study involves research about MGA271 in combination with Keytruda. MGA271 targets cancer cells that make a lot of a protein called B7-H3. Another way to say it is that the cells "overexpress" the protein. Very few normal cells express B7-H3. MGA271 is though to work by recognizing cancer cells that overexpress B7-H3 and directing the body…

PRESERVE

Condition: Surgery

Investigator: Nicholas Morrissey, MD

Status: Closed

You are being asked to be part of this study because you have been diagnosed with a bulge or aneurysm in your iliac arteries, the vessels that supply blood to the lower half of your body. As an aneurysm expands, the walls become weak and may rupture, causing a major loss of blood with a high risk of death and other serious complications. To avoid this risk…

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Medical Condition