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Displaying 201 - 206 of 206
Condition: Cancer
Investigator: Catherine Shu, MD
Status: Closed
The purpose of this study is to see if JNJ-61610588 is safe and useful for treating patients with cancer. Another purpose is to find out how long JNJ-61610588 stays in and acts on your body and how your body responds to it. The first part will find the dose of JNJ-61610588 that would be best to give to cancer patients. (A dose is measured amount of drug…
Condition: Lung Disease / Cystic Fibrosis
Investigator: Claire Keating, MD
Status: Closed
The purpose of the ELEVATE CF study is to evaluate an oral investigational medication called VX-440 tosee if it is safe, effective, and well-tolerated when taken alone or with two other oral medications(VX-661 tezacaftor and ivacaftor) in people with cystic fibrosis (CF). This triple combination(TC) is being tested to see if it improves chloride transport (…
Condition: Cancer
Investigator: Emerson Lim, MD
Status: Closed
This is the first study in humans for an investigational drug called CX-2009. CX-2009 is a Probody therapeutic containing a masked antibody (an antibody is a protein naturally occurring in the human body to fight infections and in some cases tumors) attached to a maytansine derivative (a cancer killing therapy). The study is being done to look at the…
Condition: Heart Disease
Investigator: Robert Sommer, MD
Status: Closed
The REDUCE LAP-HF I study is being conducted to evaluate the safety and performance of the InterAtrial Shunt Device (IASD) for patients with elevated left atrial pressure who remain symptomatic despite appropriate medical management. Placed by an interventional cardiologist during a standards catheter-based procedure, the IASD system creates a very small…
Condition: Cancer
Investigator: Richard Carvajal, MD
Status: Closed
This study is for patients with tumors that cannot be removed (unresectable) or has spread (metastasized) to a different part of the body. The main purpose of the study is to determine at what dose the study drug is safe and tolerated. The study drug is called ASP8374. The study also wants to see how ASP3874 is processed in the blood. When the safe dose is…
Condition: Cancer
Investigator: Benjamin Herzberg, MD
Status: Closed
The purpose of this research study is to test the safety of an investigational drug, PRT3789, at different dose levels to find out what effects, good and/or bad, PRT3789 has on Advanced or Metastatic Solid Tumors with a SMARCA4 Mutation. Mutations are changes or alterations in the DNA (genetic material) of your cells. A SMARCA4 mutation has been linked to…
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