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Lowering Insulin to Decrease Liver Fat Production

Condition: Nutrition

Status: Currently Recruiting

We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, ages 18-65, who have obesity with a body mass index of 30-45, and have been diagnosed with, or are at risk for, prediabetes and metabolic…

Study of IW-3300 in Patients with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

Condition: Urology

Investigator: Svjetlana Lozo, MD, MPH

Status: Closed

The purpose of this study is to find out if IW-3300, an investigational new drug, helps bladder pain when given as a rectal (inserted into the anus) foam. The study will test IW-3300. IW-3300 is a new drug that has been developed for treating people like you with interstitial cystitis/bladder pain syndrome. It is not yet approved by the United States Food…

A Prospective Natural History Study in Uveal Melanoma

Condition: Cancer / Uveal Melanoma

Investigator: Mariam El-Ashmawy, MD, PhD

Status: Closed

This study will develop a data registry of patients diagnosed with uveal melanoma (UM). This registry will provide data that will be used to support the development of novel therapies for this disease. In this study, we are focused on trying to better understand how uveal melanoma behaves and how it is treated at different medical centers around the country.

Investigating Problem Solving in Health Management

Condition: Nutrition

Investigator: Lena Mamykina, PhD

Status: Closed

We are conducting an academic study to understand how people solve problems related to health. In the study, participants will be presented with a hypothetical problem related to diabetes self-management and asked to use an online health application to explore information and propose a solution. We invite all participants between 18 and 65 years old, who…

Chatbot for Nutritional Coaching and Chronic Disease Self-Management

Condition: Nutrition

Investigator: Lena Mamykina, PhD

Status: Closed

Seeking participants for a study about how individuals prefer to receive nutrition recommendations to support health management and preferences for visualizing health data. Participants will be invited to complete a 60-minute session to answer questionnaires and evaluate different styles of nutrition recommendations. Alternatively, they will complete one 60…

Meal Choices Study

Condition: Nutrition

Investigator: Lena Mamykina, PhD

Status: Closed

A study for patients with uveal melanoma using study drug AEB071

Condition: Cancer / Uveal Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this study is evaluate the benefits and safety of using the combination of drugs, AEB071 and BYL719 to treat patients with an advanced form of uveal melanoma. The study will have two parts. The first part twill test different dose levels of each drug.Once the highest safe dose level is found, another group of patients will be treated at that…

Validation of electronic (web-based and smartphone) administration of measures of pelvic floor dysfunction

Condition: Urology

Investigator: Doreen Eleanor Chung, MD

Status: Closed

You will be randomly assigned to complete questionnaires via either a paper format, web-based format, or smartphone format. About 2 weeks later but before treatment begins, you will be asked to complete a different form of the questionnaire either in the office or at home. You will be emailed and/or called by research staff to remind you to complete the…

Study of LXS196 in Patients with Uveal Melanoma

Condition: Cancer / Uveal Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

You are invited to join voluntarily in a clinical research study to find out if the drug LXS196 alone or in combination with HDM201 is safe and has beneficial effects in people who have metastatic uveal melanoma. The purpose of this study is to determine the highest dose of LXS196 that can be given safely without unacceptable side effects as a single drug…

The Anti-Inflammatory Effects of Exercise and Peanut Consumption

Condition: Nutrition

Investigator: Richard Sloan, PhD

Status: Closed

We will enroll and randomly assign 30 sedentary, healthy overweight men and women to two groups. Participants will either start by consuming peanuts for 4 weeks, and then go on to exercise at high intensity intervals (HIIT) for 4 weeks, or the reverse order. We will test and compare the effect of peanuts and exercise on inflammation and heart rate…

Safety and Efficacy Study of IMCgp100 in Patients with Previously Untreated Advanced Uveal Melanoma

Condition: Cancer / Uveal Melanoma

Investigator: Mariam El-Ashmawy, MD, PhD

Status: Closed

This research study is being done to see if the study drug, IMCgp100, works and is safe as treatment for subjects with uveal melanoma who also test positive for HLA-A*0201. In this study IMCgp100 will be compared to three standard treatments: dacarbazine (a chemotherapy drug), ipilimumab (an immunotherapy drug), or pembrolizumab (an immunotherapy drug).…

A study for patients with Uveal Melanoma using the study drug Selumetinib

Condition: Cancer / Uveal Melanoma

Investigator: Mariam El-Ashmawy, MD, PhD

Status: Closed

The purpose of this study is to find out what effects, good and/or bad, intermittent dosing of the medication Selumetinib will have on you and your uveal melanoma. Selumetinib is a medication that blocks (or turns off) MEK, a protein activated in some uveal melanoma cells. Selumetinib is a MEK inhibitor. Blocking MEK may stop your cancer from growing.

A study for patients with bladder cancer using the Cysview and blue light system to detect tumors in order to prevent reoccurence

Condition: Urology

Investigator: Joel DeCastro, MD, MPH

Status: Closed

The purpose of the study is to investigate if Cysview and blue light is better than white light in detecting tumors in individuals with bladder cancer prior to and during surgery that are in follow-up for tumor recurrence. Cysview is an FDA approved drug that is used in combination with a lamp from KARL STORZ to detect tumors in the bladder (KARL STORZ D-…

A study for adults with Obstructive Sleep Apnea using a CPAP machine to view its effects on diet, physical activity and cardiovascular risk

Condition: Nutrition

Investigator: Ari Shechter, PhD

Status: Closed

We are currently looking for overweight (body mass index 25 kg/m2) men and women, age 18-65 y, to participate in a sleep study. To participate you must have been diagnosed with Obstructive Sleep Apnea within the past year, and have been prescribed continuous positive airway pressure (CPAP) but not have not yet started treatment. This is a 2-phase,…

A study for patients with advanced Uveal Melanoma using study drug IMCgp100

Condition: Cancer / Uveal Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

This is a Phase I study of a weekly intra-patient escalation dose regimen with IMCgp100 in patients with metastatic uveal melanoma (mUM). To help decide whether or not patients can take part in a research study looking at a new form of treatment for advanced uveal melanoma, their blood need to first be tested to determine their Human Leukocyte Antigen (HLA…

A registry for patients with Overactive Bladder (OAB)

Condition: Urology

Investigator: Matthew Rutman, MD

Status: Closed

This study is for adults with Overactive Bladder. The purpose of this registry is to collect information about patients who have Overactive Bladder (OAB) and who are receiving either mirabegron or another approved antimuscarinic medication (single drug). To collect this information, the study Sponsor has created a research registry. A registry is a kind of…

Study for patients with Uveal Melanoma using study drug crizotinib

Condition: Cancer / Uveal Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of the treatment part of the study is to find out what effects drug crizotinib has, good and/or bad on people with "high risk" uveal melanoma after surgery or radiation for the eye. It is thought that giving crizotinib to patients with "high risk" uveal melanoma can lower the chance the cancer will come back. Uveal melanoma…

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