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Lowering Insulin to Decrease Liver Fat Production

Condition: Nutrition

Status: Currently Recruiting

We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, ages 18-65, who have obesity with a body mass index of 30-45, and have been diagnosed with, or are at risk for, prediabetes and metabolic…

Investigating Problem Solving in Health Management

Condition: Nutrition

Investigator: Lena Mamykina, PhD

Status: Closed

We are conducting an academic study to understand how people solve problems related to health. In the study, participants will be presented with a hypothetical problem related to diabetes self-management and asked to use an online health application to explore information and propose a solution. We invite all participants between 18 and 65 years old, who…

Chatbot for Nutritional Coaching and Chronic Disease Self-Management

Condition: Nutrition

Investigator: Lena Mamykina, PhD

Status: Closed

Seeking participants for a study about how individuals prefer to receive nutrition recommendations to support health management and preferences for visualizing health data. Participants will be invited to complete a 60-minute session to answer questionnaires and evaluate different styles of nutrition recommendations. Alternatively, they will complete one 60…

Meal Choices Study

Condition: Nutrition

Investigator: Lena Mamykina, PhD

Status: Closed

Study of Avelumab + Cetuximab vs. Avelumab Alone in Advanced Cutaneous Squamous Cell Carcinoma of the Skin

Condition: Skin Cancer / Squamous Cell Carcinoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this study is to test the good and bad effects of the combined treatment, using the drugs cetuximab and avelumab as well as avelumab by itself. Avelumab is a drug that works by triggering the immune system so it can try to attack the cancer again. Avelumab works in a similar way to cemiplimab, which is the usual drug for treatment of your…

A study to assess the documentation of Hepatic Encephalopathy in clinical practice

Condition: Liver Disease / Hepatic Encephalopathy

Investigator: Robert Brown, MD, MPH

Status: Closed

The purpose of this study is to find out how doctors describe hepatic encephalopathy episodes in patients medical records in the course of their regular practice. The aim of the study is simply to collect information from their medical records about how their episodes of overt hepatic encephalopathy are described. There is nothing that will be required of…

The Anti-Inflammatory Effects of Exercise and Peanut Consumption

Condition: Nutrition

Investigator: Richard Sloan, PhD

Status: Closed

We will enroll and randomly assign 30 sedentary, healthy overweight men and women to two groups. Participants will either start by consuming peanuts for 4 weeks, and then go on to exercise at high intensity intervals (HIIT) for 4 weeks, or the reverse order. We will test and compare the effect of peanuts and exercise on inflammation and heart rate…

Study for patients with with hepatic encephalopathy using drug, rifaximin

Condition: Liver Disease / Hepatic Encephalopathy

Investigator: Robert Brown, MD, MPH

Status: Closed

The purpose of this study is to compare the time to onset of an episode of overt HE, in subjects with previously demonstrated overt HE after treatment with rifaximin 550 mg BID and lactulose, or rifaximin 550 mg BID. Subjects will be screened to confirm eligibility into the study. Once confirmed, subjects will begin the treatment phase and will be randomly…

A study for patients with recurrent or metastatic squamous cell carcinoma of the Head and Neck using study drug MEDI4736

Condition: Skin Cancer / Squamous Cell Carcinoma

Investigator: Sewanti Limaye, MD

Status: Closed

This study is for adult subjects with head and neck cancer (oral cavity, oropharynx middle part of the throat, hypopharynx bottom part of the throat, or larynx part of throat between the base of the tongue and the windpipe) that has either returned after treatment (recurrent) or is newly diagnosed. If newly diagnosed, the cancer must be metastatic,…

A study for adults with Obstructive Sleep Apnea using a CPAP machine to view its effects on diet, physical activity and cardiovascular risk

Condition: Nutrition

Investigator: Ari Shechter, PhD

Status: Closed

We are currently looking for overweight (body mass index 25 kg/m2) men and women, age 18-65 y, to participate in a sleep study. To participate you must have been diagnosed with Obstructive Sleep Apnea within the past year, and have been prescribed continuous positive airway pressure (CPAP) but not have not yet started treatment. This is a 2-phase,…

Study for patients with melanoma, non-small cell lung cancer (NSCLC) or squamous cell cancer of the head and neck (SCCHN) using drug B7-H3

Condition: Skin Cancer / Squamous Cell Carcinoma

Investigator: Richard Carvajal, MD

Status: Closed

This study is for patients with melanoma, non-small cell lung cancer (NSCLC), or squamous cell cancer of the head and neck (SCCHN) that has a protein called B7-H3 on the tumor cells or blood vessels in thetumor. The purpose of this study is to test the safety, tolerability, and most effective dose ofMGA271 in combination with ipilimumab (also called Yervoy…

A study for patients with recurrent or metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) using study drug MEDI4736

Condition: Skin Cancer / Squamous Cell Carcinoma

Investigator: Sewanti Limaye, MD

Status: Closed

This study is for patients with recurrent or metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN). This study will test the safety of an experimental anti-cancer drug (MEDI4736). MEDI4736 is an antibody (a protein produced by the defense system of the body immune system) that has been made in the laboratory. MEDI4736 boosts the ability of your…

A study for patients with recurrent or metastatic squamous cell carcinoma of the head and neck using study drug MEDI4736

Condition: Skin Cancer / Squamous Cell Carcinoma

Investigator: Sewanti Limaye, MD

Status: Closed

The purpose of this study is to determine the effectiveness and safety of study drug MEDI4736 monotherapy, tremelimumab monotherapy, and MEDI4736 and tremelimumab combination therapy in the treatment of patients with recurrent or metastatic PD-L1-negative squamous cell carcinoma of the head and neck who have progressed during or after treatment with…

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