235 Studies Now Enrolling
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Displaying 1 - 24 of 24
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Kiyohito Iigaya, PhD
Status: Currently Recruiting
Our lab is conducting brain imaging research studies investigating people's behavior. We are looking for people between the ages of 18 and 65 to be study participants. As a schizophrenia study participant, you will be asked to complete a set of self-report questionnaires probing personality traits. You will also complete a number of computer-based…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Guillermo Horga, MD, PhD
Status: Currently Recruiting
In this study, we are trying to learn more about the symptoms of psychosis, specifically to learn how alterations in the brain may produce certain experiences (including voice hearing or auditory hallucinations) that are common in people with psychosis or schizophrenia. The study involves clinical interviews, computer tests, and magnetic resonance imaging (…
Condition: Valve Disease / Mitral Valve Disease
Investigator: Isaac George, MD
Status: Currently Recruiting
This is a prospective multicenter study whose purpose is to establish the safety and effectiveness of the Edwards SAPIEN 3 and SAPIEN 3 Ultra valves with Commander delivery system in patients with severe symptomatic calcific mitral valve disease with severe mitral annular calcification (which is a progressive loss of function of the mitral valve due to…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Reilly Kayser, MD
Status: Closed
The Center for OCD Research at Columbia University Irving Medical Center is seeking individuals with obsessive-compulsive disorder (OCD) to participate in a research study, at no cost to you. This study is investigating the medicinal effects of nabilone for OCD symptoms. Nabilone is a synthetic form of tetrahydrocannabinol (THC), which is one of the active…
Condition: Valve Disease / Mitral Valve Disease
Investigator: Susheel Kodali, MD
Status: Closed
This is a randomized controlled trial (RCT) that will compare the clinical outcome of MitraClip device versus surgical repair in patients with severe primary MR who are at moderate surgical risk and whose mitral valve has been determined to be suitable for correction by MV repair surgery by the cardiac surgeon on the local site heart team. In this trial,…
Condition: Valve Disease / Mitral Valve Disease
Investigator: Susheel Kodali, MD
Status: Closed
The study is designed to compare the safety and effectiveness of the PASCAL System to the MitraClip System for reduction of degenerative mitral regurgitation.
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Amy Rapp, PhD
Status: Closed
The goal of the project is to identify differences in learning in obsessive-compulsive disorder (OCD) by measuring the activity of the brain while participants complete computer tasks. Eligible participants will be asked questions about their medical and psychiatric history and perform tasks on a computer while an electroencephalogram (EEG) is recorded.…
Condition: Valve Disease / Mitral Valve Disease
Investigator: Susheel Kodali, MD
Status: Closed
This study is designed to look at the safety and performance of The Intrepid TMVR System using transfemoral transseptal access (TF). TF is a procedure that requires access to the femoral vein by an incision in the lower limb between the knee and the hip. The study population is for patients with severe, symptomatic mitral regurgitation (MR), a condition…
Condition: Valve Disease / Mitral Valve Disease
Investigator: Susheel Kodali, MD
Status: Closed
The study is assessing the safety and effectiveness of the SAPIEN 3 transcatheter heart valve in patients with a failing mitral bioprosthetic valve.
Condition: Valve Disease / Mitral Valve Disease
Investigator: Susheel Kodali, MD
Status: Closed
The Millipede Feasibility Study is a prospective, open-label, single-arm study to assess the safety and feasibility of the Millipede Transcatheter Annuloplasty Ring System in subjects with functional mitral regurgitation. The Millipede Annuloplasty Ring System is a novel transcatheter, fully adjustable, complete annuloplasty repair device for the treatment…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Gaurav Patel, MD, PhD
Status: Closed
Our lab is conducting a series of research studies that investigate how specific brain regions are related to functioning in work, school, and in other social situations. As a study participant, you will be asked to complete clinical and neuropsychological assessments, an eye-tracking task, and a non-invasive MRI scan. Study participants earn between $15-50…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
This study is investigating how the brains of people with OCD may change with treatment. The study uses Magnetic Resonance Imaging (MRI) to scan the brain, and the treatment used is a form of Cognitive-Behavioral therapy consisting of Exposure and Ritual Prevention (EX/RP). Participants will undergo a scan, which lasts for approximately 2 hours and takes…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Yagna Pathak, PhD
Status: Closed
The study aims to assess the impact of repetitive transcranial magnetic stimulation (rTMS) on brain imaging and neurophysiological measures in patients with Obsessive-Compulsive Disorder (OCD).
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Joshua Kantrowitz, Md
Status: Closed
The purpose of this study is to determine whether the brain wave patterns are improved after administration of CVN058 compared to placebo in subjects with schizophrenia. The study uses electroencephalography (EEG) to measure naturally occurring brain waves as you listen to recorded sounds.
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
The Center for OCD and Related Disorders is currently conducting a study in treating Obsessive-compulsive Disorder (OCD), which is a severe illness characterized by distressing intrusive thoughts, images, or impulses about a variety of themes (e.g., fears of contamination or harm) and repetitive behaviors such as excessive washing or checking. The study is…
Condition: Valve Disease / Mitral Valve Disease
Investigator: Susheel Kodali, MD
Status: Closed
This trial is a non-randomized, prospective, multi-center early feasibility study to evaluate the safety and performance of the AccuCinch system in patients with Heart Failure and Reduced Ejection Fraction HFrEF
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Joshua Kantrowitz, Md
Status: Closed
The purpose of this study is to evaluate the efficacy, safety and tolerability of different doses and durations of TV-46000 given by subcutaneous (under the skin) injection as compared to placebo for use as a potential maintenance in adults with schizophrenia.
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Guillermo Horga, MD, PhD
Status: Closed
In this study, we are trying to learn more about the symptoms of schizophrenia, specifically to learn how abnormalities in the brain may produce certain experiences that are common in patients with schizophrenia. The study involves clinical interviews, clinical chart review, computer tests, and magnetic resonance imaging (MRI) scans.
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Reilly Kayser, MD
Status: Closed
The Center for OCD and Related Disorders at New York State Psychiatric Institute/Columbia University Medical Center is seeking individuals aged 18+ with obsessive-compulsive disorder (OCD) to participate in a survey regarding their experiences with marijuana/cannabis. We hope this study will lead to increased understanding of how these substances affect…
Condition: Valve Disease / Mitral Valve Disease
Investigator: Susheel Kodali, MD
Status: Closed
The purpose of this study is to evaluate a new device to treat patients who may benefit from the repair of their mitral heart valve due to mitral regurgitation. The device is called the Edwards Cardioband System (Edwards Cardioband System or the device). The device is investigational in the United States but has been approved in Europe. This clinical study…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
Eligible participants will be asked questions about their symptoms, complete questionnaires, and receive sessions of Cognitive-Behavioral therapy consisting of Exposure and Ritual Prevention (EX/RP) accompanied by the use of a mobile app. The purpose of this study is to assess whether the mobile app may be effective in improving symptoms of OCD.
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Pablo Goldberg, M.D.
Status: Closed
The purpose of this study is to assess the effects of a single infusion of ketamine for adolescents and young adults with obsessive-compulsive disorder (OCD). Ketamine is a FDA-approved anesthetic medication that can possibly cause a rapid decrease in OCD symptoms. To be eligible to participate, patients need to have already tried at least one SRI…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
The purpose of this pilot research study is to test whether certain components of the marijuana plant, known as "cannabinoids", may help to reduce symptoms in patients with OCD. Specifically, patients enrolled in the study will smoke marijuana containing different concentrations of 2 different cannabinoids, THC and CBD. Both of these agents act on…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Jeffrey Lieberman, MD
Status: Closed
This study plans to learn more about an investigational new drug called lumateperone tosylate (ITI-007) and may help us find new types of treatment for schizophrenia and schizoaffective disorder.