235 Studies Now Enrolling
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Displaying 1 - 36 of 36
Condition: Obesity
Investigator: Ilene Fennoy, MD
Status: Currently Recruiting
Bariatric surgery and a once-weekly glucagon-like peptide-1 medicine both cause major weight loss in teens, but their effects on mouth and gut bacteria and on damaged blood fats tied to metabolism are still unknown. This study will collect saliva, stool, and routine blood samples from adolescents before treatment and six months later to see how these…
Condition: Obesity
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, ages 18-65, who have obesity with a body mass index of 30-45, and have been diagnosed with, or are at risk for, prediabetes and metabolic…
Condition: Obesity
Investigator: Daphna Shohamy, PhD
Status: Currently Recruiting
We are researchers at Columbia studying the learning and decision making. We are looking for participants over the age of 18, who have been prescribed Trizepatide for weight loss. Participants will be asked to complete an MRI scan and play computer games. Participants earn $25 per hour. Help us understand how the GLP-1 agonists affect brain and cognition!
Condition: Obesity
Investigator: Faris Zuraikat, PhD
Status: Currently Recruiting
The purpose of this study is to assess energy balance during two different diet periods.
Condition: Allergy, Asthma, & Immunology / Asthma
Investigator: Meyer Kattan, MD
Status: Currently Recruiting
We are interested in learning more about these diseases and how to treat them. Our research program is conducting several studies including: a study to learn if treatment with a drug named dupilumab can help reduce asthma attacks in children, a study to observe a specific type of irritation in the lungs and how it relates to asthma symptoms, and more! If…
Condition: Obesity
Investigator: Rudolph Leibel, MD
Status: Currently Recruiting
The Physiology of the Weight Reduced State (POWERS) is a national research study designed to discover and learn what happens to the human body after weight loss and to learn why some people regain their lost weight. Understanding why this happens could help health professionals improve strategies for successful weight loss maintenance after weight loss.…
Condition: Obesity
Investigator: Judith Korner, MD
Status: Currently Recruiting
The purpose of this study is to evaluate if genetic variations are associated with the amount of weight loss with diet and while taking an FDA-approved medication for weight loss. The participation lasts ten months and includes six in-person visits at CUIMC with blood sampling and questionnaires, virtual nutritional counseling, and taking an oral weight…
Condition: Cancer / Bladder Cancer
Investigator: Alexander Wei, MD
Status: Currently Recruiting
The purpose of this study is to determine whether using LY4052031 in a type of cancer that may have tumor cells that express a protein called Nectin-4 is safe and how well the cancer responds to the study drug. LY4052031 has not been approved by the US Food and Drug Administration (FDA). This is a first in human study and all of the risks are not fully…
Condition: Obesity
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are conducting a research study on how insulin controls blood sugar in both healthy people and those at risk of type 2 diabetes. We are seeking adult volunteers, aged 18-65, who have body mass indices either in the lean range (18-25 kg/m2) or in the obesity range (30-45 kg/m2) but who do not have prediabetes or diabetes. Participants will undergo a…
Condition: Obesity
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are recruiting volunteers, aged 18-70, for a research study on the buildup of excessive liver fat ("fatty liver disease") in people with or at risk for type 2 diabetes because their bodies are resistant to the actions of the blood sugar-lowering hormone, insulin. To do this, we seek to temporarily induce or accentuate insulin resistance in 14…
Condition: Obesity
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are seeking adult volunteers with body mass index in the obesity range (30-45 kg/m2) to come in for a single study visit where they answer some health questions and have a small volume of blood drawn (25 cc/1.7 tbsp). We will measure levels of the blood sugar-lowering hormone insulin as well as glucose (sugar), certain fats, and other molecules related…
Condition: Allergy, Asthma, & Immunology / Asthma
Investigator: Meyer Kattan, MD
Status: Closed
Columbia University Medical Center along with other large medical centers across the country is participating in a research study of 6 to 17 year olds with and without asthma.
Condition: Allergy, Asthma, & Immunology / Allergy
Investigator: Joyce Yu, MD
Status: Closed
The study population includes up to 110 adult male and female participants ages 18-55 years. Participants may have multiple food allergies but must be peanut allergic in order to be included. Safety assessments will include the following: physical examination, vital signs, laboratory evaluations, and ECG (electrocardiogram).
Condition: Cancer / Bladder Cancer
Investigator: Andrew Lenis, MD
Status: Closed
This study is being done to answer the following question: Can we lower the chance of your bladder cancer growing or spreading by using one type of chemotherapy instilled in the bladder, Gemcitabine and Docetaxel, instead of the usual therapy? The usual approach for patients who are not in a study is treatment with Transurethral surgery of bladder tumor (…
Condition: Allergy, Asthma, & Immunology / Asthma
Investigator: Maria Kwok, MD, MPH
Status: Closed
The goal of this study is to determine if treating acute wheezing episodes with a 5-day course of an antibiotic called, Azithromycin is effective in shortening the duration and preventing future wheezing episodes. Azithromycin is an antibiotic taken by mouth.
Condition: Allergy, Asthma, & Immunology / Asthma
Investigator: Emily DiMango, MD
Status: Closed
Precision medicine is an individual-based care, a new approach to care based on someone's medical history, where they live, and profile (age, gender, and so on). We will use precision medicine to understand treatments for severe asthma. These treatments are not yet used for asthma today. We have two goals for the PrecISE study: 1. Make it easier to…
Condition: Cancer / Bladder Cancer
Investigator: Christopher Anderson, MD
Status: Closed
This study is for patients who have bladder cancer that has not invaded muscle tissue and who have been treated with one or more surgical resections and Bacillus Calmette-Guerin or BCG, which was directly given into the bladder before. The main purpose of this trial is to show that durvalumab is safe when given alone, in combination with BCG treatments, and…
Condition: Obesity
Investigator: Joshua Cook, MD, PhD
Status: Closed
We're conducting a research study on how much insulin is needed to control blood sugar in people who are made temporarily resistant to insulin's effects. Insulin is the main hormone (chemical signal) that the body uses to lower the levels of sugar in the blood. We are interested in looking at insulin levels because we think that lowering insulin…
Condition: Cancer / Bladder Cancer
Investigator: Joel DeCastro, MD, MPH
Status: Closed
We are doing this research to find out the safety, toxicity, and efficacy of intravesical Cabazitaxel, Gemcitabine, and Cisplatin (CGC) in the treatment of non-muscle-invasive urothelial carcinoma of the bladder that has recurred despite BCG use. The purpose of finding the maximum tolerable dose is important for future use of the drug, so as to provide the…
Condition: Cancer / Bladder Cancer
Investigator: Joel DeCastro, MD, MPH
Status: Closed
This is a Phase 1 study (the first time this treatment is being tested in humans) of an anti-cancer study drug called as PF-07225570. This study drug works on stimulating certain cells in the immune system. The study will test different doses that increase (dose escalation) and at the appropriate time, additional patients will be enrolled to evaluate this…
Condition: Allergy, Asthma, & Immunology / Asthma
Investigator: Maureen George, PhD, RN, AE-C, FAAN
Status: Closed
We are doing this research study to find out how to make it easier for people with asthma to understand and use information about their asthma through images, graphs, or diagrams. We are looking for teen-parent/guardian pairs. To be eligible, you must be a parent/guardian (18 or older) of a teen (age 12-17) who takes certain inhaled controller medication(s…
Condition: Cancer / Bladder Cancer
Investigator: Joel DeCastro, MD, MPH
Status: Closed
This research study will investigate an experimental, unapproved drug that will be given two different ways; as an injection in the bladder wall after bladder tumor resection surgery (or TURBT) and then as an intravesical instillation (fluid inserted in the bladder by catheter) right after the injection. The purpose of this study is to find the dose which…
Condition: Allergy, Asthma, & Immunology / Asthma
Investigator: Meyer Kattan, MD
Status: Closed
The reason for this nationwide study is to help us learn if treatment with German cockroach extract, given as allergy shots, given along with standard asthma care makes children less likely to have asthma symptoms. The study will take up to 36 months. Study visits will include questionnaires, a physical examination, an allergy skin test, breathing tests,…
Condition: Cancer / Bladder Cancer
Investigator: Mark Stein, MD
Status: Closed
This clinical trial is for patients who have cancer of the urinary system (urothelial cancer, including cancer of the bladder, renal pelvis, ureter or urethra) that has spread to nearby tissues or to other areas of the body who have already been treated with a kind of anticancer drug called an immune checkpoint inhibitor (CPI). This clinical trial uses an…
Condition: Allergy, Asthma, & Immunology / Asthma
Investigator: Joyce Yu, MD
Status: Closed
The purpose of this global study is to provide evidence of the efficacy and safety of 210 mg dose of tezepelumab administered every 4 weeks subcutaneously in adults and adolescents (12 years of age and older) with a history of asthma exacerbations and severe uncontrolled asthma receiving medium or high dose inhaled corticosteroids plus at least one…
Condition: Cancer / Bladder Cancer
Investigator: Joel DeCastro, MD, MPH
Status: Closed
The purpose of this study is to look at a new treatment for non-muscle-invasive bladder cancer. This new form of paclitaxel, a drug currently used by injection into a vein to treat various types of cancer, is designed to be instilled (injected) into the urinary bladder with a catheter (tube) placed into your bladder through your urethra (the opening where…
Condition: Allergy, Asthma, & Immunology
Investigator: Joyce Yu, MD
Status: Closed
The population includes males and females of all ages with one or more food allergy or those who are at risk of mortality from food-induced anaphylaxis. The FARE Patient Registry is a multicenter, prospective, longitudinal, observational cohort study of patients with food allergy. The participant and the treating physician agree that he/she will complete…
Condition: Cancer / Bladder Cancer
Investigator: Joel DeCastro, MD, MPH
Status: Closed
This study is being conducted to evaluate the performance of the AssureMDx test for the detection of bladder cancer in patients presenting with hematuria.
Condition: Allergy, Asthma, & Immunology
Investigator: Micaela Martinez, PhD
Status: Closed
How does the light we experience in day-to-day life affect our body clock? Interested in joining a new project to help scientists at Columbia University understand how light pollution and light-at-night affects our body clock? You or your child may be eligible to participate. The study involves wearing a small light sensor on a lanyard and a temperature…
Condition: Cancer / Bladder Cancer
Investigator: Joel DeCastro, MD, MPH
Status: Closed
The purposes of this clinical study are: To evaluate the safety and tolerability of up to 2 drug release periods of GemRIS for up to 7 days per drug release period To evaluate the pharmacokinetics (the study of the bodily absorption, distribution, metabolism, and excretion of the drug) of gemcitabine and a gemcitabine-related metabolite (product after…
Condition: Allergy, Asthma, & Immunology / Asthma
Investigator: Joyce Yu, MD
Status: Closed
This study is designed to examine the efficacy and safety profile of dupilumab over one year in a population of asthmatic children in need for an additional treatment to their current maintenance management. Patients are randomized to either dupilumab or matching placebo administered standard care for a maximum treatment duration of 52 weeks. The…
Condition: Cancer / Bladder Cancer
Investigator: Joel DeCastro, MD, MPH
Status: Closed
The study is part of a research program to assess the efficacy of the drug nab-rapamycin, a biologic mTOR inhibitor. The purpose of the study is to assess the response rate, as well as, the safety of administering nab-rapamycin in combination with gemcitabine directly into the bladder in an effort to treat bladder cancer. The study seeks to determine if…
Condition: Allergy, Asthma, & Immunology / Asthma
Investigator: Meyer Kattan, MD
Status: Closed
Asthma registry to maintain and expand a database of participants with asthma who may be able to participate in future Inner City Asthma Consortium studies.
Condition: Cancer / Bladder Cancer
Investigator: Christopher Anderson, MD
Status: Closed
This research is being done to study the effects, safety, and tolerability of the study drugs Nivolumab and Urelumab when given to people with advanced bladder cancer that has spread into the muscle tissue, also called Muscle-Invasive Urothelial Carcinoma of the Bladder (MIBC). Specifically, this research study will have participants either take Nivolumab…
Condition: Allergy, Asthma, & Immunology
Investigator: Joyce Yu, MD
Status: Closed
This is an experimental research study for individuals with allergy to peanuts or peanut-containing food. Oral (by mouth, not injection) immunotherapy may reduce a patients sensitivity to a specific allergen by exposing the patient to small amounts of the substance causing the allergic reaction and then gradually increasing the amount of allergen over time…
Condition: Cancer / Bladder Cancer
Investigator: Emerson Lim, MD
Status: Closed
The purpose of this study is to test how well the drug works, safety, and side effects of the experimental drug called BMS-986205. BMS-986205 will be added to another cancer medicine called nivolumab plus chemotherapy for participants who have bladder cancer that has grown into the muscle wall of the bladder. These drugs will be compared to just…