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Displaying 1 - 27 of 27
Condition: Cancer / Liver Cancer
Investigator: Linda Wu, MD
Status: Currently Recruiting
The purpose of this study is to test the safety of an investigational drug called ALN-BCAT, and find out what effects, if any, ALN-BCAT has on people with your type of liver cancer. The effects being studied include: the frequency and severity of side effects (to determine if the drug is safe); whether ALN-BCAT may make tumors smaller; how ALN-BCAT may…
Condition: Cancer / Liver Cancer
Investigator: Elizabeth Verna, MD
Status: Currently Recruiting
This study aims to use new technology involving molecular and imaging tests to help detect liver cancer early in patients. Participants enrolled will participate in it for approximately 5 years. Participation will last approximately 3 months. If you have any questions regarding this study, please contact the Transplant Clinical Research Center (TCRC).
Condition: Rehabilitation
Investigator: Sunil Agrawal, PhD
Status: Currently Recruiting
Standing postural control, or the ability to maintain an upright posture, is needed for most daily activities. People with Spinal Cord Injury (SCI) may find it challenging to maintain postural control and therefore, have difficulty moving between positions, such as lying down or sitting up, or reaching for objects that are beyond an arm's distance…
Condition: Cancer / Kidney Cancer
Investigator: Karie D. Runcie, MD
Status: Currently Recruiting
The purpose of this study is to assess whether an investigational drug called XmAb819 has any effects on Clear Cell Renal Cell Carcinoma, to determine if it is safe and well tolerated, and to determine the dosing schedule. The investigational drug will be given by intravenous (IV into the vein) infusion over a 2-hour period. This study will also see how the…
Condition: Cancer / Kidney Cancer
Investigator: Mark Stein, MD
Status: Closed
The purpose of this study is to determine if the use of immunotherapy nivolumab and the targeted therapy cabozantinib prior to removal of the kidney will increase the number subjects who are without any visible kidney cancer in their body at some point during the course of treatment. The study will also evaluate the changes that nivolumab and cabozantinib…
Condition: Cancer / Kidney Cancer
Investigator: Karie D. Runcie, MD
Status: Closed
The purpose of this study is to study two experimental drugs called canakinumab and spartalizumab produced by Novartis to see if: It is safe and feasible to give canakinumab and spartalizumab prior to radical nephrectomy; canakinumab and spartalizumab can kill cancer cells and bring immune cells into the kidney cancer when given to human subjects prior to…
Condition: Cancer / Liver Cancer
Investigator: Linda Wu, MD
Status: Closed
The purpose of this study is to compare the effects, good or bad, of tiragolumab plus atezolizumab plus bevacizumab versus placebo plus atezolizumab plus bevacizumab on patients with HCC. In this study, participants will be randomized you will get either tiragolumab plus atezolizumab plus bevacizumab or placebo plus atezolizumab plus bevacizumab. A placebo…
Condition: Rehabilitation
Investigator: Lenin Grajo, PhD
Status: Closed
We are looking for adults with diverse cultural backgrounds who are formal caregivers of older adults with functional or mobility limitations. We are conducting a research study to investigate how participating in an online discussion forum called a Community of Practice (CoP) helps increase caregiver competence for caregivers of diverse cultural…
Condition: Rehabilitation
Investigator: Lenin Grajo, PhD
Status: Closed
This program aims to help improve adult caregivers of stroke survivors ability to care for their stroke survivors with their daily needs. Each session will cover different topics which are important for caregivers to understand in order to best engage in their new role. Topics will include, but are not limited to: bathing, toileting, dressing, transfers,…
Condition: Cancer / Kidney Cancer
Investigator: Antonio Fojo, MD, PhD
Status: Closed
Axitinib (AG-013736) is an investigational (experimental) drug that is being studied in patients with metastatic pheochromocytoma/paraganglioma. The main goal of this study is to find out if axitinib is able to stop tumors from growing, or shrink tumors in patients with this type of cancer.
Condition: Rehabilitation / Cerebral Palsy
Investigator: Joel Stein, MD
Status: Closed
The purpose of this study is to: 1. Determine if a tele-rehabilitation home exercise program is helpful in promoting adherence to an exercise program in adults with CP and 2. to determine if a tele-health exercise program improves fitness and functional mobility in adults with CP. This study involves participation in a 10-week remote (Zoom) program to…
Condition: Rehabilitation / Cerebral Palsy
Investigator: Margaret O'Neil, PT, PhD, MPH
Status: Closed
Ambulatory youth with cerebral palsy (CP) aged 8-16 years old are invited to participate in a virtual reality (VR) game play session to learn about youth motivation and satisfaction with VR to promote fitness and mobility. The session will be approximately 2 hours and will be conducted in the Programs in Physical Therapy (PT) PACE Lab @ 617 W. 168th St.,…
Condition: Rehabilitation / Cerebral Palsy
Investigator: Joel Stein, MD
Status: Closed
We are looking for adults with cerebral palsy who are 18 and over for ultrasound study of nerves at the wrist. We are assessing the symptoms of Carpal Tunnel Syndrome in adults with cerebral palsy. The study will involve a survey to describe their medical history, procedures (especially of the arms), use of adaptive equipment (such as walkers, wheelchairs…
Condition: Cancer / Kidney Cancer
Investigator: Mark Stein, MD
Status: Closed
This research study is a phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational treatment to learn whether the intervention works in treating a specific disease. Investigational means that the intervention is being studied. The Food and Drug Administration (FDA) has approved Nivolumab as treatment for…
Condition: Cancer / Liver Cancer
Investigator: Gulam Manji, MD, PhD
Status: Closed
The purpose of this study is to compare the effects, good or bad, of atezolizumab plus bevacizumab versus observation (not receiving any treatment) on patients with completely resected (surgically removed) or ablated (removed using heat) hepatocellular carcinoma (the most common type of liver cancer) who are at high risk for disease recurrence.…
Condition: Cancer / Kidney Cancer
Investigator: Mark Stein, MD
Status: Closed
This study will test whether cabozantinib in combination with nivolumab plus ipilimumab is more effective (works better) than nivolumab plus ipilimumab alone in treating patients with advanced kidney cancer who have not received prior treatment for their cancer. This study will also examine how safe cabozantinib is in combination with nivolumab plus…
Condition: Cancer / Liver Cancer
Investigator: Gulam Manji, MD, PhD
Status: Closed
The purpose of this study is to assess the safety, tolerability, and effectiveness of RO7070179 given to patients with Hepatocellular Carcinoma (HCC), a primary type of liver cancer, with normal to moderately impaired liver function. RO7070179 is given intravenously to study its effects in the treatment of liver cancer. RO7070179 is an investigational anti-…
Condition: Cancer / Liver Cancer
Investigator: Susan Bates, MD
Status: Closed
The purpose of this study is to compare any good and bad effects of using atezolizumab alone or with another drug called cobimetinib. About 82 people are expected to taking part in this study. Adding cobimetinib to atezolizumab could help to shrink your cancer, but it could also cause extra side effects. This study will allow the researchers to know whether…
Condition: Cancer / Kidney Cancer
Investigator: Emerson Lim, MD
Status: Closed
We are doing this study to test a drug called MGD009. MGD009 is like an antibody, which is a protein in your blood that helps get rid of germs in your body. MGD009 is made to attach to cancer cells and to T-cells, which are a part of your immune system. Certain T cells have the ability to kill other cells, including cancer cells. By attaching to cancer…
Condition: Cancer / Liver Cancer
Investigator: Gulam Manji, MD, PhD
Status: Closed
This research study is being done to see how an investigational drug called DKN-01 combined with standard cancer drugs (gemcitabine and cisplatin) works in people with biliary or gallbladder cancer. DKN-01 is an antibody that blocks the function of another protein in the body called dickkopf-1 (Dkk-1). Too much (over expression) of the Dkk-1 protein has…
Condition: Cancer / Liver Cancer
Investigator: Susan Bates, MD
Status: Closed
This study is designed to evaluate the efficacy and safety of the study drug AG-120 as compared to placebo in patients with advanced cholangiocarcinoma. AG-120 blocks an abnormal form of a protein called IDH1, which is involved in cancer cell metabolism. Abnormal IDH1 causes too much of a substance called 2-HG to be produced. Researchers believe that having…
Condition: Cancer / Liver Cancer
Investigator: Elizabeth Verna, MD
Status: Closed
Patients will be asked to participate in this research study because they have been diagnosed with hepatocellular carcinoma (HCC) which is a type of liver cancer. By doing this study, researchers hope to: Find out more about patients that have HCC including their age, race/ethnicity, and other medical conditions they may have; learn more about how…
Condition: Cancer / Kidney Cancer
Investigator: Emerson Lim, MD
Status: Closed
This study is for patients who have renal cell carcinoma (RCC; a type of kidney cancer) and are at a high risk of disease coming back (disease recurrence) following either nephrectomy (surgical procedure to remove all or part of a kidney) or metastasectomy (removal of cancerous growth that has spread away from your kidney). The purpose of this study is to…
Condition: Rehabilitation / Cerebral Palsy
Investigator: Heakyung Kim, MD
Status: Closed
Abnormal muscle tightness -known as spasticity- in the leg can happen when a child has cerebral palsy. If your child has spasticity, they may find it difficult to straighten their leg and experience stiffness. The goal of this study is to collect information from participants about the safety and effectiveness of using BOTOX to treat arm and hand spasticity…
Condition: Rehabilitation / Cerebral Palsy
Investigator: Heakyung Kim, MD
Status: Closed
Abnormal muscle tightness -known as spasticity- in the arm and hand can happen when a child has cerebral palsy. If your child has spasticity, they may find it difficult to straighten their hand and/or arm and experience stiffness. The goal of this study is to collect information from participants about the safety and effectiveness of using BOTOX to treat…
Condition: Cancer / Liver Cancer
Investigator: Yvonne Saenger, MD
Status: Closed
The purpose of this study is to learn more about TPST-1120. The aims of the study are to find out if TPST-1120 can be given safely to people, to determine a safe dose of the study drug, if it is safe when given in combination with other anti-cancer drugs, what effects the drug may have, and to learn more about how the body processes the study drug. This is…
Condition: Cancer / Liver Cancer
Investigator: Gulam Manji, MD, PhD
Status: Closed
The purpose of this study is to test the safety, tolerability, and anti-tumor activity of the research study drug, Pembrolizumab (also known as MK-3475) in subjects with advanced hepatocellular carcinoma (a type of liver cancer also referred to as HCC) who have taken sorafenib.
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