235 Studies Now Enrolling
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Displaying 201 - 210 of 210
Condition: Cancer / Sarcoma
Investigator: Gary Schwartz, MD
Status: Closed
The purpose of this study is to determine if the study drug toripalimab is safe, to determine future doses to give to patients with cancer, and to measure the amount of toripalimab in the blood. Up to approximately 240 subjects will be enrolled in Part B. The dose given in Part B will be 240 mg. The dose was chosen based upon safety data obtained from…
Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Closed
The overall goal of this project is to determine whether short sleep duration is a risk factor for cardiovascular disease in women. We are currently looking for healthy, non-smoking women to participate in a sleep study. You must be willing to come to Columbia University Medical Center once a week for two 6-week periods and regularly sleep at least 7-9…
Condition: Healthy Volunteers
Investigator: Loren Gianini, PhD
Status: Closed
The goal of this study is to better understand why some people have managed to lose weight and keep it off while others have not. We are recruiting people who have lost weight and kept it off as well as healthy non-dieters with overweight or obesity who are not trying to lose weight. Study participation involves computer tasks, brain imaging, and eating a…
Condition: Healthy Volunteers
Investigator: Eldad Hod, MD
Status: Closed
One of the consequences of donating blood is iron deficiency. In this study, we will screen healthy frequent blood donors for iron deficiency. We will enroll iron deficient donors and randomize them to intravenous iron treatment or placebo in order to determine whether iron deficiency has any harmful effects on the blood supply and the donors themselves.
Condition: Healthy Volunteers
Investigator: Blandine Laferrere, MD, PhD
Status: Closed
This pilot study is designed to examine the effect of a novel type of lifestyle intervention, administered via a smartphone app, on weight loss and improvement of metabolic health in individuals with overweight and/or obesity. A mobile application will be used to document eating behavior through photos. In addition, participants will receive personalized…
Condition: Healthy Volunteers
Investigator: Karen Marder, MD, MPH
Status: Closed
This study is recruiting people who have a family history of a neurodegenerative diseases, such as Alzheimer's disease or other form of dementia including frontotemporal dementia and prion disease, who are interested in doing predictive genetic testing. Participants will complete questionnaires prior to testing and then 1 month and 6 months after…
Condition: Healthy Volunteers / Exercise
Investigator: Richard Sloan, PhD
Status: Closed
This study focuses on the effects of aerobic conditioning on cardiovascular function and inflammatory response. Eligible participants will complete an exercise stress test, laboratory visit, and cognitive testing session at three specific time points over the course of the study. Once the initial set of appointments is complete, participants are randomly…
Condition: Healthy Volunteers
Investigator: Jeffrey Miller, MD
Status: Closed
The purpose of this study is to use Positron Emission Tomography (PET) to identify changes in brain chemistry that may cause an episode of depression. This study will be carried out in approximately 30 subjects. PET is a technique that provides "pictures" of chemical connections in the brain by injecting and monitoring a radioactive substance. In…
Condition: Healthy Volunteers
Investigator: Julie Franks, PhD
Status: Closed
Almost 40,000 people get HIV in the U.S. each year and almost all infections occur via sexual contact, especially male-to-male contact. The number of new infections has decreased slightly each year; however, we need other HIV prevention tools, including an effective HIV vaccine, to better protect people from HIV infection. An HIV vaccine is the best long-…
Condition: Healthy Volunteers
Investigator: Sharon Wardlaw, MD
Status: Closed
This 2-phase study aims to explore ways to predict who will respond well to the FDA approved weight loss drug lorcaserin and to understand the mechanisms that develop which limit drug efficacy. Subjects will be recruited for a 5-week crossover study (phase 1) with lorcaserin and placebo followed by treatment with lorcaserin for 24 weeks (phase 2). Phase 1…