Search

Displaying 201 - 221 of 221

Donor Iron Deficiency Study

Condition: Healthy Volunteers

Status: Closed

One of the consequences of donating blood is iron deficiency. In this study, we will screen healthy frequent blood donors for iron deficiency. We will enroll iron deficient donors and randomize them to intravenous iron treatment or placebo in order to determine whether iron deficiency has any harmful effects on the blood supply and the donors themselves.

Weight Loss Maintenance

Condition: Healthy Volunteers

Investigator: Loren Gianini, PhD

Status: Closed

The goal of this study is to better understand why some people have managed to lose weight and keep it off while others have not. We are recruiting people who have lost weight and kept it off as well as healthy non-dieters with overweight or obesity who are not trying to lose weight. Study participation involves computer tasks, brain imaging, and eating a…

Weight Loss Maintenance

Condition: Healthy Volunteers

Investigator: Loren Gianini, PhD

Status: Closed

A study for patients with solid tumors using study drug ASP5878

Condition: Cancer / Solid Tumors

Investigator: Emerson Lim, MD

Status: Closed

The purpose of this research study is to confirm the safety of ASP5878. It is also intended to assess how the body reacts to ASP5878 after administration, how ASP5878 functions in the body, and the antitumor effect of the ASP5878. Participants in this study will have been diagnosed with urothelial carcinoma, hepatocellular carcinoma, or squamous cell lung…

Predictive testing for neurodegenerative diseases

Condition: Healthy Volunteers

Investigator: Karen Marder, MD, MPH

Status: Closed

This study is recruiting people who have a family history of a neurodegenerative diseases, such as Alzheimer's disease or other form of dementia including frontotemporal dementia and prion disease, who are interested in doing predictive genetic testing. Participants will complete questionnaires prior to testing and then 1 month and 6 months after…

A study to understand language abilities in adults as they age

Condition: Healthy Volunteers

Investigator: Marla Hamberger, PhD

Status: Closed

The purpose of this project is to develop a set of word finding or naming tests for adults, ages 66 and above. The main task involves naming pictures of common objects (e.g. broom), or naming items when given a description (e.g. "what children ride to school in"). There are some other tasks as well such as single word reading, number repetition,…

TREAT Pilot Study

Condition: Healthy Volunteers

Investigator: Blandine Laferrere, MD, PhD

Status: Closed

This pilot study is designed to examine the effect of a novel type of lifestyle intervention, administered via a smartphone app, on weight loss and improvement of metabolic health in individuals with overweight and/or obesity. A mobile application will be used to document eating behavior through photos. In addition, participants will receive personalized…

Predictors of Lorcaserin-Induced Weight Loss

Condition: Healthy Volunteers

Investigator: Sharon Wardlaw, MD

Status: Closed

This 2-phase study aims to explore ways to predict who will respond well to the FDA approved weight loss drug lorcaserin and to understand the mechanisms that develop which limit drug efficacy. Subjects will be recruited for a 5-week crossover study (phase 1) with lorcaserin and placebo followed by treatment with lorcaserin for 24 weeks (phase 2). Phase 1…

My Pathway: Study Evaluating Drug in Patients with Advanced Solid Tumors with Mutations or Gene Expression Abnormalities

Condition: Cancer / Solid Tumors

Investigator: Emerson Lim, MD

Status: Closed

Four different treatment regimens will be evaluated simultaneously in groups of patients who have advanced solid tumors that has progressed following administration of standard of care treatment, or for whom no standard therapy exists, or for whom therapies that will convey clinical benefit are not available, and in whom a trial of targeted therapy is…

The purpose of this study is to test a combination of vaccines against HIV. We want to see if the vaccines prevent people from getting HIV.

Condition: Healthy Volunteers

Investigator: Julie Franks, PhD

Status: Closed

Almost 40,000 people get HIV in the U.S. each year and almost all infections occur via sexual contact, especially male-to-male contact. The number of new infections has decreased slightly each year; however, we need other HIV prevention tools, including an effective HIV vaccine, to better protect people from HIV infection. An HIV vaccine is the best long-…

A study for patients with locally advanced or metastatic solid tumors using study drug demcizumab

Condition: Cancer / Solid Tumors

Investigator: Catherine Shu, MD

Status: Closed

The purpose of this study is to test the efficacy and safety of an experimental drug, demcizumab, when given in combination with pembrolizumab (Arm A of the study). Demcizumab is a humanized monoclonal antibody and was developed to target cancer stem cells. Demcizumab may block the growth of cancer stem cells, in addition to the remaining cancer cells, and…

Study Comparing Two Copper IUDs

Condition: Healthy Volunteers

Investigator: Paula Castano, MD, MPH

Status: Closed

Columbia University is conducting a contraceptive clinical trial looking at two intrauterine devices, one of which is investigational. Pre-menopausal women ages 16-40 who are generally healthy, sexually active, at risk for pregnancy, and are not at risk for sexually transmitted infections may qualify.

Online Men's Health Survey

Condition: Healthy Volunteers

Investigator: Rebecca Schnall, PhD, RN

Status: Closed

Take the Online Men's Health Survey (OMHS) today! Human Immunodeficiency Virus (HIV) and syphilis disproportionately affect men who have sex with men (MSM); however, this phenomenon is not well understood and is understudied in the United States. The OMHS study is being performed to help improve STI prevention and treatment services in the United…

IMAGene: A study for healthy volunteers evaluating how genes affect health risks

Condition: Healthy Volunteers

Investigator: Julia Wynn

Status: Closed

This study is evaluating genomic screening in Ashkenazi Jewish and Hispanic communities. Genomic screening is done by collecting a blood sample and looking at a person's genes to learn if they are at high risk for certain health problems like cancer or heart disease or are at risk to have a child with a genetic condition. The study is designed to…

Study of Experimental Drug GSK3359609 in Patients with Advanced Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: Brian Henick, MD

Status: Closed

GSK3359609 is a drug that is a type of antibody. It is a kind of immunotherapy that targets the ICOS (anti-Inducible T cell Co-Stimulator) protein present on specific immune cells. ICOS is a cell receptor that enhances the immune response to foreign bodies, and which is expected to help your immune system find and fight cancer cells. It will also be called…

Antibodies for HIV Prevention

Condition: Healthy Volunteers

Investigator: Magdalena Sobieszczyk, Md

Status: Closed

We are looking for healthy, HIV-negative individuals 18 to 50 years old who are interested in our studies that test antibodies for HIV prevention. Antibodies are one of the natural ways that our bodies fight or prevent infection. We are testing an antibody called VRC07-523LS against HIV. We will ask you to complete a brief questionnaire to find out if you…

BAT activation due to sleep restriction

Condition: Healthy Volunteers

Investigator: Marie-Pierre St-Onge, PhD

Status: Closed

We are doing this research study to find out how different amounts of sleep restriction affect yourbody's ability to generate heat. This study will determine the effects of partial sleep restriction (PSR) (4 h in bed) and total sleep deprivation (TSD) (0 h in bed) compared to a full night of habitual sleep (HS)(8 h in bed) on brown adipiose tissue (…

Seeking your opinions towards organ donation policies

Condition: Healthy Volunteers

Investigator: Sumit Mohan, MD

Status: Closed

We are seeking your opinions regarding different organ donation policies, via a 5-10 minute survey; responses are all anonymous. Everyone who completes the survey will have the option to enter a draw for a $5 gift card.

A study for patients with advanced or metastatic solid tumors using study drug ulocuplumab combined with nivolumab

Condition: Cancer / Solid Tumors

Investigator: Naiyer Rizvi, MD

Status: Closed

This study is an open-label, multicenter phase 1/2 study. The study is designed in two parts, the first is designed to evaluate the safety of the study drug ulocuplumab in combination with nivolumab in subjects with small cell lung cancer (SCLC) and pancreatic adenocarcinoma (PAC). Subjects will receive a low dose of ulocuplumab in combination with…

Exercise, Age-Related Memory Decline, and Hippocampal Function

Condition: Healthy Volunteers / Exercise

Investigator: Richard Sloan, PhD

Status: Closed

This study focuses on the effects of aerobic conditioning on cognition and brain activity. Eligible participants will complete an exercise stress test, MRI, and cognitive testing session at the beginning and end of the study. Once participants complete the first set of appointments, they will be randomly assigned to one of two conditions for 12-weeks.…

Study of Biological Aging Among African Americans (Healthy Volunteers)

Condition: Healthy Volunteers

Investigator: Stephen Arpadi, MD, MS

Status: Closed

We are seeking healthy volunteers (HIV-negative) for a study seeing if HIV is associated with faster biological aging among older African American adults, whether faster biological age is related to health conditions that typically occur in older people and whether these conditions might be due to stress or over-activity of certain parts of the immune…

This website uses cookies as well as similar tools and technologies to understand visitors’ experiences. By continuing to use this website, you consent to Columbia University’s usage of cookies and similar technologies, in accordance with the Columbia University Website Cookie Notice.

I AGREE

Status

Medical Condition