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A Study for Patients with Advanced Melanoma, Solid Tumors or Lymphoma Using Study Drug Pembrolizumab

Condition: Pediatrics / Cancer

Status: Currently Recruiting

The purpose of this study is to determine if a study drug called pembrolizumab is safe and effective in the treatment of children and adolescents who have advanced melanoma, or advanced, relapsed, or refractory PD-L1 positive malignant solid tumor or other lymphoma, relapsed or refractory classical Hodgkin lymphoma (rrcHL), advanced, relapsed or refractory…

Study of Memory Loss in Patients with Alzheimers Disease or Mild Cognitive Impairment (MCI)

Condition: Neurological Disorders

Investigator: Catherine Clelland, PhD

Status: Currently Recruiting

This research study aims to obtain a greater understanding of the causes of cognitive decline in Alzheimer's disease. We are currently enrolling male and female participants (ages 55 years and older) with Alzheimer's disease, mild cognitive impairment, or healthy controls. Enrolled participants with undergo a small blood draw (about 8 teaspoons)…

CHORD Clinical Trial - Gene Therapy DB-OTO for Children with Hearing Loss from Otoferlin (OTOF) Gene Mutation

Condition: Pediatrics

Investigator: Lawrence Lustig, MD

Status: Currently Recruiting

The CHORD clinical trial, sponsored by Decibel Therapeutics, is looking at the use of the gene therapy DB-OTO for children born with hearing loss related to changes in the OTOF gene. The goal of this trial is to assess different doses of DB-OTO to find out if it is safe, well-tolerated, and its effect on improving hearing. DB-OTO is a gene therapy that has…

Congenital Anomalies Research Exploration - CARE study

Condition: Pediatrics

Investigator: Yufeng Shen, PhD

Status: Currently Recruiting

Study examining the genetic causes of birth defects

Congenital Anomalies Research Exploration - CARE study

Condition: Healthy Volunteers

Investigator: Yufeng Shen, PhD

Status: Currently Recruiting

Study examining the genetic causes of birth defects

Cerebral Palsy Patient Registry

Condition: Neurological Disorders / Cerebral Palsy

Investigator: Jason Carmel, MD, PhD

Status: Currently Recruiting

The Weinberg Family Cerebral Palsy Center's (WFCPC) research team maintains a cerebral palsy (CP) patient registry of more than 1,000 enrolled patients. This registry contains information collected from children and adults with CP. The goal of the registry is to help us learn more about CP and neuromuscular diseases, to understand the quality of life…

The Dawn Study - Genetics of Alzheimer's Disease

Condition: Neurological Disorders / Alzheimer's Disease

Investigator: Giuseppe Tosto, MD PhD

Status: Currently Recruiting

This study aims to find genes that cause Alzheimer's Disease in African Americans and Hispanics/Latinos. Participants are eligible if African American or Hispanic/Latino and 60 years of age or older. Study participation would entail completing a memory assessment, having their blood drawn, and a brief physical exam with a questionnaire. Compensation of…

Smell and Taste Disturbances in COVID-19

Condition: Ear, Nose and Throat / Loss of Smell

Investigator: Jonathan Overdevest, MD, PhD

Status: Currently Recruiting

Our research team at Columbia University is trying to understand the impact of COVID-19 on smell and taste (chemosensory) dysfunction among adult patients from the Greater New York City area. Current areas of study include: 1) Investigation of smell and taste recovery patterns among patients with COVID-19; 2) Studies on how recovery of smell and taste after…

REBIRTH - Study of Bromocriptine in Women with Peripartum Cardiomyopathy (PPCM)

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Jennifer Haythe, MD

Status: Currently Recruiting

We are doing this study to test the use of a drug called bromocriptine for women with a condition called Peripartum cardiomyopathy (PPCM). The study will look at how the heart muscle improves in women taking bromocriptine compared to a group of women given a placebo or inactive pill.

REBIRTH - Study of Bromocriptine in Women with Peripartum Cardiomyopathy (PPCM)

Condition: Heart Disease / Cardiomyopathy

Investigator: Jennifer Haythe, MD

Status: Currently Recruiting

IMPROVE 2 - Well-Being in Emergency Medicine After COVID 19

Condition: COVID-19 (Coronavirus)

Investigator: Bernard Chang, MD, PhD

Status: Currently Recruiting

The purpose of this study to examine the long-term general psychological symptoms, and identify the predictors of these psychological symptoms. The sustained psychological toll of working in a high-stress environment can have downstream impacts on health. It is therefore important to also consider how psychological factors influence physical health, for…

Columbia University Biobank

Condition: Healthy Volunteers

Investigator: Muredach Reilly, MD

Status: Currently Recruiting

As an academic medical center, we are always working to improve patient and population health. One way that research is supported here is through the Columbia University Biobank (CUB). A biobank is a collection of biological samples and health data gathered during a patient's medical care. Participants in a biobank help researchers find treatments and…

Stick2PrEP: Women/Trans/Non-Binary Individuals

Condition: Infectious Disease / HIV

Investigator: Magdalena Sobieszczyk, Md

Status: Currently Recruiting

Do you identify as a woman or transgender person, or do you have a non-binary gender identity? Has a medical provider ever diagnosed you with a sexually transmitted infection or recommended PrEP/another HIV prevention method? We are conducting a study to understand attitudes and preferences regarding HIV prevention methods among people who do not have HIV.…

Learning to Perform Reaching and Lifting Movements Using a Robotic Interface

Condition: Healthy Volunteers

Investigator: Daniel Wolpert, PhD

Status: Currently Recruiting

The Sensorimotor Learning Lab at Columbia University is conducting behavioral studies of how our brains control movement. We are looking for volunteers to take part in experiments involving moving in virtual reality, interacting with robotic interfaces and other movement tasks. All the experiments are noninvasive and have been approved by the Columbia IRB.…

Collection of Blood and Skin Samples from Patients with Hair and Skin Disorders

Condition: Hair and Skin Disorders

Investigator: Angela Christiano, PhD

Status: Currently Recruiting

The purpose of this study is to examine the causes and pathology of alopecia areata and other hair and skin disorders. Skin biopsies and blood and/or clinical information collected in the study will be used for research aiming at developing new options for the treatment of alopecia areata and other skin and hair disorders.

Development of Biomarkers for Radiation Exposure

Condition: Healthy Volunteers

Investigator: David Brenner, PhD

Status: Currently Recruiting

The purpose of this study is to use blood from healthy people to develop a test to see if people have been exposed to radiation. Between 2 and 3 tablespoons of blood will be drawn from your arm. The blood will be tested with radiation in our laboratory at the Center for Radiological Research at the Columbia University Irving Medical Center. We will measure…

Study of Women After Menopause who are Taking Medication and/or Receiving Counseling/Therapy for Depression

Condition: Psychiatric Disorders / Depression

Investigator: Marcella Walker, MD

Status: Currently Recruiting

Depression and some antidepressants may be associated with an increased risk of breaking a bone. It is not clear why this could be the case. It is possible that depression and/or certain medications used for the treatment of depression cause bone loss, increase the risk of falls, are associated with lower physical activity, or effects on muscle function.…

Study of Women After Menopause who are Taking Medication and/or Receiving Counseling/Therapy for Depression

Condition: Bone & Muscle

Investigator: Marcella Walker, MD

Status: Currently Recruiting

Smell and Taste Disturbances in COVID-19

Condition: COVID-19 (Coronavirus)

Investigator: Jonathan Overdevest, MD, PhD

Status: Currently Recruiting

Program for Overweight Education and Reduction (POWER)

Condition: Pediatrics

Investigator: Ilene Fennoy, MD

Status: Currently Recruiting

We are doing this research study to find out what happens to children who are overweight and how the things we recommend as a part of routine clinical care affect your child. The purpose of this study is to understand what happens to children as a result of being overweight, to link these outcomes to specific clinical measures, and to determine how…

Study of HMGA2 in Young Women with Lymphangioleiomyomatosis (LAM)

Condition: Lung Disease

Investigator: Jeanine Marie D'Armiento, MD

Status: Currently Recruiting

Lymphangioleiomyomatosis (LAM) is a rare lung disease primarily affecting young women. Currently, LAM is often diagnosed in patients with radiology imaging (CTs) and/or lung biopsies; however, these methods can be imprecise, invasive, and/or can carry significant risks. The current study aims to devise a less invasive tool for diagnosis of this rare…

Genome Research in African American Scleroderma Patients (GRASP Study)

Condition: Autoimmune Disorders

Investigator: Elana Bernstein, MD

Status: Currently Recruiting

This research is being done to determine how variations in genes may explain the different risk to develop scleroderma (or CREST) seen in African American patients compared to other populations. People who are African American with scleroderma (or CREST) may join. This research involves a blood draw and physical exams.

HIV Prevention Study

Condition: Infectious Disease / HIV

Investigator: Magdalena Sobieszczyk, Md

Status: Currently Recruiting

We are looking for individuals 18 to 65 years old who are interested in learning more about HIV prevention and biomedical research studies. We will ask you to complete a brief questionnaire to find out if we can schedule you for a one-on-one, 1.5-hour education visit to learn about the research we do. The education visit will help you decide if you want to…

HIV Prevention Study

Condition: Healthy Volunteers

Investigator: Magdalena Sobieszczyk, Md

Status: Currently Recruiting

Speech Perception in Hearing Impaired Listeners

Condition: Ear, Nose and Throat / Hearing Loss

Investigator: Nima Mesgarani, PhD

Status: Currently Recruiting

The purpose of this study is to learn more about the mechanisms of hearing loss, specifically to learn how abnormalities in the brain may produce certain experiences that are common in patients with hearing loss. Individuals with hearing loss will be compared to individuals with normal hearing.

Molecular Basis of Cardiopulmonary Disorders

Condition: Lung Disease

Investigator: Christine Kim Garcia, MD

Status: Currently Recruiting

The purpose of this study is to identify genetic causes of lung diseases and to develop a research repository so that we can better understand, prevent and treat these conditions. You should consider joining this study if you have been diagnosed with a lung disease that has a genetic cause or if other family members have been diagnosed with a similar lung…

The Molecular Basis of Cardiopulmonary Disorders (Healthy Participants and Children Over 7 Welcome)

Condition: Healthy Volunteers

Investigator: Christine Kim Garcia, MD

Status: Currently Recruiting

The purpose of this study is to identify genetic causes of lung diseases and to develop a research repository so that we can better understand, prevent and treat these conditions. You have been asked to join this study as a healthy control. Even though you do not have lung disease, your sample is valuable to us. For example, you may be related to someone…

The PhenoGenetic Project

Condition: Healthy Volunteers

Investigator: Philip De Jager, PhD

Status: Currently Recruiting

The purpose of this study is to establish a collection of biological fluids and associated data from healthy individuals to determine how genetic and environmental variation affects the immune system. Study visits consist of taking vitals and collecting biological fluids, such as blood. You will be compensated for participating in this study.

Screening for COVID-19 Vaccine, Prevention and Treatment Research Studies

Condition: COVID-19 (Coronavirus)

Investigator: Magdalena Sobieszczyk, Md

Status: Currently Recruiting

We are looking for individuals over 18 years old who are interested in learning more about COVID-19 prevention research studies. We will ask you to complete a brief questionnaire to find out if you may be eligible for one of our studies. We can then schedule a phone call, teleconference, or in-person education visit so you can learn about the research we do…

COVID-19 Vaccine Biomarker Study in Multiple Sclerosis and Other Neuroimmunological Diseases

Condition: Neurological Disorders

Investigator: Rebecca Straus Farber, MD

Status: Currently Recruiting

We need your help today to gather information about the experience of patients with autoimmune diseases of the central nervous system (multiple sclerosis (MS), neuromyelitis optica (NMO), and anti-MOG associated disease (MOGAD)) in regards to COVID-19 vaccines. Because individuals with MS, NMO, and MOGAD were not included in the COVID-19 vaccine trials, we…

MS Snapshot: A Study to Better Understand Multiple Sclerosis

Condition: Neurological Disorders / Multiple Sclerosis

Investigator: Philip De Jager, PhD

Status: Currently Recruiting

The Snapshot study aims to understand brain and spinal cord aging in healthy individuals and individuals with multiple sclerosis (MS). We aim to identify new tools that will help us to achieve successful brain aging in the general population and in people with an underlying autoimmune disease. A critical aspect of this study is that we are looking for…

Healthy Brain Donation Project - Brain Bank

Condition: Healthy Volunteers

Investigator: Philip De Jager, PhD

Status: Currently Recruiting

Medtronic Product Surveillance Registry Post Approval Network (PAN)

Condition: Heart Disease

Investigator: Frederick Ehlert, MD

Status: Currently Recruiting

The purpose of this registry is to collect information over time about how Medtronic products are working and/or the outcome of the treatment. The registry will be used to support post-market surveillance/monitoring activities and post-approval studies (e.g., to collect safety and performance information). In addition, it will be used to obtain clinical…

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