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A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma

Condition: Cancer / Brain Cancer

Status: Closed

The purpose of this research study is to see if the combination of medications approved for the treatment of glioblastoma, together with the study drug, selinexor (also known as XPOVIO), has any effects on your cancer. Selinexor works by trapping tumor suppressor proteins within the cell nucleus. This is expected to cause the cancer cells to die or stop…

Study of androgen deprivation therapy followed by chemoimmunotherpy for newly metastatic hormone-sensitive prostate cancer (mHSPC)

Condition: Cancer / Prostate Cancer

Investigator: Mark Stein, MD

Status: Closed

The purpose of this study is to determine if the addition of immunotherapy to the current standard of care for metastatic prostate cancer, chemotherapy, and hormonal therapy, is safe and improves your response to therapy. People who usually have metastatic prostate cancer to their bones and organs are usually treated with combination of chemotherapy (…

A First-in-Human Study of CDK-002 (exoSTING) in Subjects with Advanced/Metastatic Solid Tumors

Condition: Cancer

Investigator: Matthew Ingham, MD

Status: Closed

The purpose of this study is to test the safety and dose of CDK-002 alone in subjects with cancer that is considered advanced and/or has spread to other parts of the body. CDK-002 is an investigational study drug that is being developed for the potential treatment of cancer. This is a first-in-human study. CDK-002 is a drug designed to activate the immune…

Study of BMS-986218 + Degarelix Acetate vs. Degarelix Acetate Alone in Men with Prostate Cancer

Condition: Cancer / Prostate Cancer

Investigator: Karie D. Runcie, MD

Status: Closed

The purpose of this study is to see whether immunotherapy with BMS-986218 added to degarelix (which suppresses your testosterone) given prior to surgery can decrease the chance that your cancer will come back compared to degarelix alone. People who usually have this type of prostate cancer usually do not receive any additional therapy prior to surgery.

The mLab Study: Help Us Research HIV Testing & Earn Up to $170!

Condition: Infectious Disease / HIV

Investigator: Rebecca Schnall, PhD, RN

Status: Closed

The mLab study at Columbia University is looking for cisgender men or trans women who are 18-29 years old and have sex with guys. Eligible individuals can earn up to $170 by participating in the online study and completing 3 surveys over the course of 1 year. Contact us if you are interested! Text/Call: 347-743-0104

ASPIRE: Study of Anastrozole, Palbociclib, Trastuzumab and Pertuzumab Metastatic Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Melissa Accordino, MD

Status: Closed

The purpose of this study is to assess the safety and effectiveness of giving anastrozole, palbociclib, trastuzumab, and pertuzumab to women with hormone receptor-positive, HER2-positive metastatic breast cancer. This combination of medications represents an all-biologic approach and avoids chemotherapy as first-line treatment of this disease.

A Study of CYNK-001 in Adults with Newly Diagnosed Acute Myeloid Leukemia

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this clinical research study is to evaluate the safety (any good or bad effects) of CYNK-001 and to assess the effects of CYNK-001 on your Acute Myeloid Leukemia (AML). Also, the study plans to determine the maximum tolerated dose (highest safe dose) of CYNK-001 and assess whether CYNK-001 can eliminate your residual (leftover) disease.…

A Study of PTC596 in Combination With Dacarbazine in Participants With Advanced Leiomyosarcoma (LMS)

Condition: Cancer / Sarcoma

Investigator: Matthew Ingham, MD

Status: Closed

The purpose of this study is to evaluate the effectiveness of a new investigational drug, PTC596, used in combination with dacarbazine, for the treatment of locally recurrent, unresectable, or metastatic relapsed/refractory leiomyosarcoma, a type of soft tissue sarcoma. The purpose of this study is to evaluate whether adding PTC596 to dacarbazine is safe…

Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers

Condition: Cancer

Investigator: Brian Henick, MD

Status: Closed

The purpose of this study is to explore how the combination of the study drugs affects tumors and general health. The study drugs are BMS-986253 and nivolumab. Participants will be given different doses of BMS-986253 and nivolumab to test how safe they are in humans. This is the first study in which BMS-986253 is being given in combination with nivolumab.

Study of Multiple Treatment Combinations in Patients with Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer)

Condition: Cancer / Pancreatic Cancer

Investigator: Gulam Manji, MD, PhD

Status: Closed

The purpose of this study is to learn which treatment works best in patients with pancreatic cancer. The study explores multiple treatment combinations. A study drug called atezolizumab may be combined with other drugs such as cobimetinib, PEGPH20, and BL-8040. Patients may also be assigned to receive standard chemotherapy treatment.

Study of COM701 Alone and in Combination with Nivolumain in Patients with Advanced Solid Tumors (Breast Cancer/Ovarian Cancer/Lung Cancer)

Condition: Cancer

Investigator: Benjamin Izar, MD

Status: Closed

The main purposes of this research study are: to find a safe and tolerated dose of the study drug COM701 alone and in combination with nivolumab; and to measure the amount of COM701 that is in the blood at different times after it is given. This study is for people with advanced cancer (solid tumor) that no longer responds to standard approved therapies.

Study of PBCAR269A in Participants With Relapsed/Refractory Multiple Myeloma

Condition: Cancer / Multiple Myeloma

Investigator: Ran Reshef, MD

Status: Closed

The purpose of this research study is to obtain information on the safety and effectiveness of PBCAR269A to treat certain types of cancers. PBCAR269A is a new investigational treatment for certain types of cancer of the blood, such as multiple myeloma. It is made from a type of blood cells known as T cells. The T cells in PBCAR269A came from people who have…

First-in-Human Study of PF-07225570 Alone or in Combination with Sasanlimab for Patients with Non-Muscle Invasive Bladder Cancer (NMIBC)

Condition: Cancer / Bladder Cancer

Investigator: Joel DeCastro, MD, MPH

Status: Closed

This is a Phase 1 study (the first time this treatment is being tested in humans) of an anti-cancer study drug called as PF-07225570. This study drug works on stimulating certain cells in the immune system. The study will test different doses that increase (dose escalation) and at the appropriate time, additional patients will be enrolled to evaluate this…

Study of RTX-240 in Adults with Relapsed/Refractory or Locally Advanced Solid Tumors

Condition: Cancer

Investigator: Mark Stein, MD

Status: Closed

The purpose of this study is to learn about the study drug RTX-240. This study is the first time RTX-240 will be used in people. Researchers will be studying the safety and effectiveness of RTX-240 in patients with certain types of cancer. The study will check if RTX-240 causes any changes in your health (or side effects), how well it may work at treating…

First-in-Human Study of DS-7300a in Subjects with Advanced Cancer

Condition: Cancer

Investigator: Mark Stein, MD

Status: Closed

This study will test the investigational drug, DS-7300a, for the first time in humans. DS-7300a is an antibody-drug conjugate (ADC) being developed as an anti-cancer agent. ADCs are made up of a monoclonal antibody chemically linked to a drug. The monoclonal antibody binds to specific proteins or receptors found on certain types of cells, including cancer…

Study of Drug PLX2853 in Subjects with Advanced Cancer

Condition: Cancer / Solid Tumors

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this study is to determine the highest dose of the study drug that can be given safely to people with certain cancers. The study will also look at how effective the study drug is in treating certain cancers. The study drug is PLX2853. The participants in this study will be the first people to receive PLX2853.

Study of Intratumorally Administered INT230-6 in Adult Subjects with Solid Tumors

Condition: Cancer

Investigator: Matthew Ingham, MD

Status: Closed

The main purpose of this study is to determine the safety of administering an investigational new drug (referred to as INT230-6 or the study drug) directly into multiple superficial (you can feel them with touch) and deep tumors (such as those within the body or inside an organ e.g. the liver). Investigational means that INT230-6 has not yet been approved…

Cemiplimab Survivorship Epidemiology (CASE) Study

Condition: Cancer / Skin Cancer

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of the study is to determine the long-term effectiveness and safety of cemiplimab in patients diagnosed with Cutaneous Squamous Cell Carcinoma (CSCC, a type of skin cancer).

PLX2853 with Abiraterone Acetate, Prednisone, and Olaparib in Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Condition: Cancer / Prostate Cancer

Investigator: Mark Stein, MD

Status: Closed

In Phase 1b, the purpose is to learn how well patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) tolerate the treatment when PLX2853 is added to ongoing treatment with abiraterone acetate and prednisone. We are looking for the highest dose of PLX2853 that can be given safely to patients with your type of disease who are already on…

Study of AG-881 in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO)

Condition: Cancer / Brain Cancer

Investigator: Andrew Lassman, MD

Status: Closed

This study is being done to evaluate the safety and usefulness of the study drug, AG-881, as compared to placebo (a medically inactive substance) in residual or recurrent non-enhancing Grade 2 glioma (a type of brain cancer) that has a mutation in the IDH1 or IDH2 metabolic enzyme (a substance produced by the body to assist in breaking down chemicals).…

Study of Safety of New Investigational Study Drug Alone and with Nivolumab in Advanced Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: Mark Stein, MD

Status: Closed

The purpose of the study is to test the safety of an investigational study drug called BMS-986249. BMS-986249 will be given alone and in combination with nivolumab. This study will investigate how patients with advanced solid tumors tolerate these drugs. The study will identify the highest dose or most suitable dose of BMS-986249 alone and in combination…

Study of ONC201 in Adults With Recurrent H3 K27M-mutant Glioma

Condition: Cancer / Brain Cancer

Investigator: Andrew Lassman, MD

Status: Closed

The purpose of this research study is to test how safe and how well an investigational drug known as ONC201 works in treating high grade glioma (a type of brain cancer). The FDA (the U.S. Food and Drug Administration) has not approved ONC201 as a treatment for this condition.

Study of efficacy of ribociclib plus fulvestrant in patients with metastatic breast cancer

Condition: Cancer / Breast Cancer

Investigator: Melissa Accordino, MD

Status: Closed

The purpose of this study is to determine whether there is clinical benefit to continue therapy beyondprogression for metastatic or unresectable breast cancer. The treatment that is being investigated in this clinical trial, ribociclib (LEE011), is part of a family of oral medications (pills) that are called Cyclin Dependent Kinase 4 and 6 inhibitors, which…

Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

Condition: Cancer / Sarcoma

Investigator: Gary Schwartz, MD

Status: Closed

The purpose of this study is to find out if an investigational drug, called ADP-A2M4, is safe and how well it works in attacking Synovial Sarcoma or Myxoid/Round Cell Liposarcoma (MRCLS) cancer cells. The study involves taking certain types of immune cells from the blood, called T cells, and changing them in a laboratory before putting them back into the…

Study of Durvalumab + Tremelimumab in Non-Small Cell Lung Cancer Patients After Adjuvant Treatment

Condition: Cancer / Lung Cancer

Investigator: Catherine Shu, MD

Status: Closed

The purpose of this research study is to see how effective durvalumab andtremelimumab is in patients with early stage non-small cell lung cancer (NSCLC). A a special blood test will be done to see if subjects have circulating tumor DNA (ctDNA) in their blood. ctDNA are pieces of genetic material shed from the tumor cells that can be detected in the blood,…

Study of Ablation in Breast Cancer Patients

Condition: Cancer / Breast Cancer

Investigator: Eileen Connolly, MD, PhD

Status: Closed

The purpose of the study is to determine whether ablation, which is the removal or destruction of a tumor (through SBRT and/or surgical resection of all known metastases) in oligometastatic breast cancer patients improves progression-free survival (PFS) and overall survival (OS).

Study of Avelumab + Cetuximab vs. Avelumab Alone in Advanced Cutaneous Squamous Cell Carcinoma of the Skin

Condition: Skin Cancer / Squamous Cell Carcinoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this study is to test the good and bad effects of the combined treatment, using the drugs cetuximab and avelumab as well as avelumab by itself. Avelumab is a drug that works by triggering the immune system so it can try to attack the cancer again. Avelumab works in a similar way to cemiplimab, which is the usual drug for treatment of your…

Immatics Biomarker Screening

Condition: Cancer

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this research study is to find out if you can take part in one or more of the treatment studies sponsored by Immatics. The "treatment studies" involve adoptive cellular therapy (ACT), a type of therapy in which T cells (a type of immune cell) are given to a participant to help the body fight diseases, such as cancer. If your tumor…

A First-in-Human Study Using BDC-1001 in Advanced and HER2-Expressing Solid Tumors

Condition: Cancer

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this study is to learn about the study drug BDC-1001 in patients with HER2-expressing tumors. Researchers will be studying the use of BDC-1001 alone as well as in combination with Pembrolizaumab. This study will help researchers learn if the study drug can help with HER2-expressing tumors and how people respond to the drug. The researchers…

Cannabinoids for Taxane-Induced Peripheral Neuropathy in Women Undergoing Breast Cancer Treatment

Condition: Cancer / Breast Cancer

Investigator: Diana Martinez, MD

Status: Closed

Paclitaxel is frequently used to treat breast cancer, but it can also cause neuropathy where the nerves of the hands and feet stop working properly. The symptoms of neuropathy can include pain, numbness, and difficulty with everyday activities like walking or typing. Paclitaxel-induced neuropathy is common and there are few treatment options. Our study will…

A Study of ZN-c5 in Subjects With Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Katherine Crew, MD

Status: Closed

This research study involves receiving an experimental drug referred to as ZN-c5. This is the first study in humans using ZN-c5. The purpose of this research study is to test the safety of ZN-c5 at different dose levels. This study is designed to find out what effects, good and/or bad, ZN-c5 has on participants with breast cancer. Participants in both…

Study of Drug in Patients with B-Cell Lymphoid Malignancies

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

This research study is evaluating an investigational drug, called cirmtuzumab, in combination with astandard drug, called ibrutinib (Imbruvica), as a possible treatment for patients with CLL/SLL or MCL. All cells in the body receive signals to grow and survive, but sometimes these signals get out of control, causing too much cell growth. When the growth of…

Study of XmAb22841 Monotherapy and in Combination with Pembrolizumab in Subjects with Selected Advanced Solid Tumors (DUET-4)

Condition: Cancer / Solid Tumors

Investigator: Mark Stein, MD

Status: Closed

The primary purpose of this research study is to learn the safety and tolerability of the investigational drug, XmAb 22841 when given alone or in combination with another drug called pembrolizumab. You will be assigned to either receive XmAb22841 alone or in combination with pembrolizumab and you will know what treatment you are receiving. This study will…

Study of GEN-011 for Adult Patients with Advanced Cancer

Condition: Cancer

Investigator: Mark Stein, MD

Status: Closed

GEN-011 is an experimental treatment being evaluated in adult patients with advanced cancer. GEN-011 is a T cell therapy made specific to each patient, using the patient's own circulating immune cells. First, the cancer proteins that are already recognized by the patient's T cells are found. Then, immune cells that recognize these cancer proteins…

Study of HPN424 in Patients With Advanced Prostate Cancer

Condition: Cancer / Prostate Cancer

Investigator: Mark Stein, MD

Status: Closed

The purpose of this study is to test the effectiveness and safety of an experimental drug known as HPN424 (also known as study drug) in patients with advanced prostate cancer. This drug has been tested in animals but not yet in people. This study tests different doses of HPN424. We want to find out how good the drug is at treating prostate cancer. We also…

Study to Compare Bempegaldesleukin with Nivolumab vs. Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence

Condition: Skin Cancer / Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of the study is to evaluate the effectiveness (how well the drug works) of the investigational drug called bempegaldesleukin when combined with drug nivolumab in comparison with nivolumab alone after complete resection (removal of all sites of known disease) of melanoma in participants at high risk of cancer returning after surgery (recurrence).

A Study of Rucaparib as Treatment for Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: June Hou, MD

Status: Closed

The experimental drug being investigated in this study is called rucaparib. Rucaparib is being developed by Clovis Oncology, Inc. (the Sponsor), a biopharmaceutical company with headquarters in the United States (US). Rucaparib (trade name: Rubraca) is a medicine that is approved in the European Union (EU) and the US for use in certain types of ovarian…

Study of Antibody Drug in Patients with Advanced Renal Cell Carcinoma

Condition: Cancer / Kidney Cancer

Investigator: Mark Stein, MD

Status: Closed

This research study is a phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational treatment to learn whether the intervention works in treating a specific disease. Investigational means that the intervention is being studied. The Food and Drug Administration (FDA) has approved Nivolumab as treatment for…

Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging

Condition: Cancer

Investigator: Andrew Lassman, MD

Status: Closed

The purpose of the study is to evaluate the tolerability of a ketogenic diet in conjunction with metformin in people with malignant glioma. The study doctors will try to determine if maintaining the ketogenic diet with metformin will have any effect on your tumor.

Glucose Monitoring to Determine Rates of Hyperglycemia During Chemotherapy for Early Stage Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Melissa Accordino, MD

Status: Closed

The purpose of this study is to identify if blood sugar elevations during chemotherapy may be related to the development of side effects from chemotherapy. This study will help us find out if blood sugar goes up during the course of chemotherapy, and if so, for the amount of time the blood sugar is elevated after a chemotherapy treatment. Results of this…

Study of Ipilimumab in Combination with Nivolumab in Subjects with High-risk Ocular Melanoma

Condition: Skin Cancer / Melanoma

Investigator: Mariam El-Ashmawy, MD, PhD

Status: Closed

This research study is a phase II clinical trial that will study the combination of adjuvant nivolumab and ipilimumab for the treatment of adult subjects with completely treated high-risk ocular melanoma. This study is being done to see if the combination of the study drugs is safe and effective in preventing the return of their cancer. If you are eligible…

Study for Patients with Anaplastic Astrocytoma That Progress/Recur After Radiation and Chemotherapy

Condition: Cancer / Brain Cancer

Investigator: Andrew Lassman, MD

Status: Closed

The purpose of this study is to measure how well and how safe eflornithine is in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma has come back after radiation and chemotherapy. Safety and how well you can tolerate the drug will be determined on the basis of physical exams, laboratory tests,…

Study of a Neoantigen Cancer Vaccine in Patients with Advanced Solid Tumors (Bladder, Colon, Stomach, Lung, Esophageal, or Rectal Cancer)

Condition: Cancer

Investigator: Brian Henick, MD

Status: Closed

The purpose of this research study is to learn more about an experimental personalized vaccine that has two components called GRT-C901 and GRT-R902. We will learn more about the effects of this vaccine on your cancer when used together with approved medications that activate the immune system, nivolumab (Opdivo) as well as ipilimumab (Yervoy), which are…

A Study of ASP1951 in Subjects with Advanced Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: Brian Henick, MD

Status: Closed

The main purpose of the study is to determine at what dose the study drug (ASP1951) is safe and tolerated and how it is processed in the blood of subjects with tumors that cannot be removed (unresectable) or has spread (metastasized) to a different part of the body. When the safe dose is identified, it will be used to evaluate if the study drug treatment…

Study of Experimental Drug for Triple Receptor-Negative Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Meghna Trivedi, MD

Status: Closed

The purpose of this study is to compare the usual approach (i.e. no more treatment or additional post-operative chemotherapy), to any effects, good and/or bad, of the experimental drug MK-3475 (also called pembrolizumab) after surgery. This study will allow the researchers to know whether treatment with MK-3475 (pembrolizumab) is better, the same, or worse…

TCR-engineered T Cells in Solid Tumors With Focus on Non-small Cell Lung Cancer (NSCLC) and Head and Neck Squamous Cell Carcinoma (HNSCC)

Condition: Cancer

Investigator: Ran Reshef, MD

Status: Closed

The goal of the study is to learn if it is safe to give genetically changed T cells (IMA201) in combination with standard of care chemotherapy (fludarabine and cyclophosphamide) and IL-2 (aldesleukin) to patients with solid tumors that have grown or returned after being treated. Researchers also want to learn about possible side effects of IMA201 and if the…

Study of T-Cells (IMA202-101) Given in Combination with Chemotherapy to Patients with Solid Tumors

Condition: Cancer

Investigator: Ran Reshef, MD

Status: Closed

The goal of the overall study is to learn if it is safe to give genetically changed T cells (IMA202) in combination with standard of care chemotherapy (fludarabine and cyclophosphamide) and IL-2 (aldesleukin) to patients with melanoma solid tumors that have grown or returned after being treated. Researchers also want to learn about possible side effects of…

Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer

Condition: Cancer / Gastrointestinal

Investigator: Rachael Safyan, MD

Status: Closed

This study is being done to answer the following question: Does duloxetine (either 30 mg or 60 mg) prevent numbness, tingling, and/or pain caused by your colorectal cancer treatment with oxaliplatin? We are doing this study because we want to find out if duloxetine can prevent Oxaliplatin-Induced Peripheral Neuropathy (OIPN).

Study Evaluating BI 1387446 Alone and in Combination with BI 754091 in Solid Tumors

Condition: Cancer

Investigator: Matthew Ingham, MD

Status: Closed

The purpose of this study is to test the safety and effectiveness of the study drug, BI 1387446, given alone or combined with the study drug, BI 754091, in subjects with different types of advanced cancer. BI 1387446 will be injected directly into at least one tumor site. BI 754091 will be given by intravenous (IV) infusion, which is a slow injection of the…

Study of AMG-232 with Preoperative Radiotherapy in Subjects with Soft Tissue Sarcoma (STS)

Condition: Cancer / Sarcoma

Investigator: Gary Schwartz, MD

Status: Closed

The purpose of this study is to test the safety of a study drug called AMG 232 given with radiation in patients with soft tissue sarcoma (STS) prior to surgery. The AMG 232 is investigational. It has been tested in other cancers but not yet in sarcoma. AMG 232 has not been tested using the dosing schedule in this study and it has not been tested with…

Study to Evaluate AL102 in Patients with Progressing Desmoid Tumors - DUPLICATE

Condition: Cancer / Sarcoma

Investigator: Gary Schwartz, MD

Status: Closed

You are being asked to participate in this study because you have been diagnosed with a progressive desmoid tumor. The purpose of this study is to see if the study drug, called AL102 (referred to from now on as the study drug), is safe and effective in people with progressive desmoid tumors. The study will also look at how your body responds to the study…

Dose-Finding Study of Pacritinib in Patients With Leukemia Previously Treated With Ruxolitinib

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

The purpose of this study is to find out what dose of pacritinib is safest and works best for participants. Pacritinib is an experimental drug, which is a drug that is being tested and is not currently approved by the Food and Drug Administration (FDA) in the US. The study will be conducted at about 85 study clinics in North America, Europe, Israel and…

Study of Drug (XmAb20717) in Subjects with Advanced Solid Tumors (DUET-2) - Melanoma, Breast Cancer, Lung Cancer, Stomach Cancer

Condition: Cancer

Investigator: Mark Stein, MD

Status: Closed

This research study will learn more about the drug, XmAb20717. XmAb20717 is designed to activate your own cells to kill your tumor. The primary purposes of this research study are to: determine the safety and tolerability of XmAb20717, see if XmAb20717 works in treating specific tumors , learn about the side effects from XmAb20717. Cancers include:…

A Study of BA3021 in Patients with Advanced Solid Tumors (Lung Cancer, Triple Negative Breast Cancer, or Soft Tissue Sarcoma)

Condition: Cancer / Solid Tumors

Investigator: Brian Henick, MD

Status: Closed

BioAtla (the sponsor of the clinical trial) is studying BA3021 as a potential treatment for varieties of cancers including but not limited to lung, triple negative breast cancer and soft tissue sarcoma. The purpose of this research study is to test the safety of different doses of BA3021 and to find out what effects, good and/or bad, it has on the body and…

A Study of LGK974 in Patients With Cancer

Condition: Cancer

Investigator: Richard Carvajal, MD

Status: Closed

This primary purpose of this study is to find the recommended dose of LGK974 and PDR001 that can be safely given to adult patients who have advanced metastatic pancreatic cancer, or triple negative breast (TNB) cancer, or melanoma, lung squamous cell cancer, esophageal squamous cell cancer, cervical squamous cell cancer, or head and neck squamous cell…

Study of Immunotherapy with Nivolumab or BMS-986253 Added to Degarelix in Patients with Prostate Cancer (MAGIC-8)

Condition: Cancer / Prostate Cancer

Investigator: Mark Stein, MD

Status: Closed

This study is for patients with prostate cancer and that require treatment because their disease is now growing. The purpose of this study is to see whether immunotherapy with nivolumab added to degarelix or nivolumab and BMS-986253 added to degarelix is safe and can decrease the chance that the cancer will come back. Degarelix is a standard of care drug…

Cabozantinib With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Kidney Cancer (COSMIC-313)

Condition: Cancer / Kidney Cancer

Investigator: Mark Stein, MD

Status: Closed

This study will test whether cabozantinib in combination with nivolumab plus ipilimumab is more effective (works better) than nivolumab plus ipilimumab alone in treating patients with advanced kidney cancer who have not received prior treatment for their cancer. This study will also examine how safe cabozantinib is in combination with nivolumab plus…

Study of NanoDoce Injection and as Fluid Inserted in Bladder in Subjects with Bladder Cancer

Condition: Cancer / Bladder Cancer

Investigator: Joel DeCastro, MD, MPH

Status: Closed

This research study will investigate an experimental, unapproved drug that will be given two different ways; as an injection in the bladder wall after bladder tumor resection surgery (or TURBT) and then as an intravesical instillation (fluid inserted in the bladder by catheter) right after the injection. The purpose of this study is to find the dose which…

Study of Uproleselan (GMI-1271) in Combination With Chemotherapy to Treat Relapsed/Refractory Acute Myeloid Leukemia

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to: Test if the lifespan of study participants is increased when uproleselan is added to standard chemotherapy medicines compared to standard chemotherapy alone; test if the number of study participants achieving disease remission is increased when uproleselan is added to standard chemotherapy medicines compared to standard…

Study of Glutaminase Inhibitor CB-839 HCl in Subjects with Advanced Solid Tumors

Condition: Cancer

Investigator: Brian Henick, MD

Status: Closed

The purpose of this study is to test the good and bad effects of the drug called CB-839 HCl (telaglenastat). CB-839 HCl (telaglenastat) could shrink your cancer, but it could also cause side effects. The study doctors hope to learn if the study drug will help control the disease in patients with advanced cancer with changes in specific genes. We don't…

Olaparib With or Without Atezolizumab in Treating Patients With Locally Advanced or Metastatic Non-HER2-Positive Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Meghna Trivedi, MD

Status: Closed

The purpose of this study is to compare any good and bad effects of using olaparib and atezolizumab in combination compared to olaparib alone. The use of olaparib alone or in combination with atezolizumab could shrink your cancer but could also cause side effects. This study will allow the researchers to know whether the combination approach is better, the…

A study for patients with Central Nervous System Lymphoma (PCNSL) or Primary Testicular Lymphoma (PTL) using study drug Nivolumab

Condition: Cancer / Lymphoma

Investigator: Fabio Iwamoto, MD

Status: Closed

The purpose of this study is to test the effectiveness (how well the drug works), safety, and tolerability of an investigational drug called nivolumab (also known as BMS-936558). This study will see if treatment with nivolumab increases the chance you will have a positive response (complete or partial) in treating your primary central nervous system…

Determining Changing in Cardiovascular and Metabolic Risks in Patients with Chronic Myeloid Leukemia

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

This study will see how the treatment you will receive for your chronic myeloid leukemia affects cardiovascular and metabolic risk factors. The treatments that are being studied are called BCR-ABL1 tyrosine kinase inhibitors (TKIs) (i.e., dasatinib, imatinib, nilotinib). Subjects who are eligible for the study will be starting treatment for chronic myeloid…

Efficacy and Safety of Naloxone Lotion for Treatment of Itchiness in Patients with Mycosis Fungoides (MF) Form of Cutaneous T-cell Lymphoma

Condition: Cancer / Lymphoma

Investigator: Larisa Geskin, MD

Status: Closed

This is a phase 2 study to determine the efficacy and safety of Naloxone HCL Lotion 0.5% for the treatment of mycosis fungoides (MF) type of cutaneous T-cell lymphoma (CTCL). Selected subjects will have the study drug applied to determine its effect on reducing itchiness and any potential side effects. Naloxone has previously been approved for direct blood…

Study of Telaglenastat in First-Line, Metastatic KEAP1/NRF2-Mutated, Nonsquamous, Non-Small Cell Lung Cancer (NSCLC)

Condition: Cancer / Lung Cancer

Investigator: Brian Henick, MD

Status: Closed

The purpose of this study is to determine the amount (dose) of telaglenastat that is safe and tolerable when given together with the recommended treatment regimen of pembrolizumab, carboplatin, and pemetrexed and to determine if the combination of standard drugs with telaglenastat is more active against non-small cell lung cancer (NSCLC) than the standard…

A study for adults with previously-treated metastatic pancreatic adenocarcinoma using study drug GVAX

Condition: Cancer / Pancreatic Cancer

Investigator: Paul Oberstein, MD

Status: Closed

The purpose of this study is to test whether GVAX pancreas vaccine and CRS-207 together are safe and work better than chemotherapy to treat individuals with advanced pancreatic cancer who have received at least one prior chemotherapy treatment for metastatic cancer. This study will also look at whether CRS-207 alone is safe and works better than…

Study of Rigosertib in Patients with Myelodysplastic Syndrome (MDS)

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

The purpose of this study is to determine how well a drug called rigosertib works on people with MDS and to study the safety of rigosertib when it is given to people with MDS. Rigosertib is currently being tested in other clinical research studies.

An Efficacy and Safety Trial of Fedratinib in Subjects With Myelofibrosis and Previously Treated With Ruxolitinib (FREEDOM)

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

You are being asked to take part in this study because you have been diagnosed with Myeloproliferative neoplasm (MPN) Associated Myelofibrosis (your disease) and have received ruxolitinib. The purpose of this study is to confirm how well this study treatment works to reduce your spleen volume, spleen size, what effect the study treatment has on you and…

A study for patients with non-small cell lung cancer using study drug AZD9291

Condition: Cancer / Lung Cancer

Investigator: Sewanti Limaye, MD

Status: Closed

The FLAURA Study is a new clinical research study underway in NSCLC and we are looking for people who would like to join. This study will examine an investigational drug, called AZD9291, and compare it tostandard, approved drugs that are already used to treat lung cancer. These drugs are called gefitinib and erlotinib. When we talk about investigational, it…

Study of Combination of Letrozole Plus Letrozole as Endocrine Therapy for Women with Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Meghna Trivedi, MD

Status: Closed

The goal of this study is to determine if ribociclib in combination with letrozole as neoadjuvant endocrine therapy increases the proportion of women with PEPI score of 0 at surgery, compared to patients treated with letrozole alone therefore allowing more patients excellent outcomes without chemotherapy. The PEPI score measures the risk of breast cancer…

A study for patients with Acute Myeloid Leukemia (AML) using study drug ASP2215

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of the study is to see if a medicine called ASP2215 is both effective and safe as atreatment for AML patients with mutations in FLT3 gene identified by an investigational FLT3Mutation Assay companion diagnostic (a specific way to test your blood or bone marrow, which is used to see if you have a mutation of the FLT3 gene), compared to salvage…

FRACTION: Study of Drug Combinations in Patients with Advanced Renal Cell Carcinoma

Condition: Cancer / Kidney Cancer

Investigator: Emerson Lim, MD

Status: Closed

We are doing this study to test a drug called MGD009. MGD009 is like an antibody, which is a protein in your blood that helps get rid of germs in your body. MGD009 is made to attach to cancer cells and to T-cells, which are a part of your immune system. Certain T cells have the ability to kill other cells, including cancer cells. By attaching to cancer…

A study for patients with AML, MDS, Myelofibrosis or solid tumors using study drug INCB059872

Condition: Cancer

Investigator: Matthew Ingham, MD

Status: Closed

This study is for patients with AML or myelodysplastic syndrome (MDS), SCLC ( other solid tumors, such as endocrine tumors or Myelofibrosis. In this research study we are going to determine how safe and well tolerated the study drug INCB059872 is in subjects/research participants with those types of cancer. Other reasons for this study are to study the…

A Study of DCC-2618 in Patients with Advanced Malignancies

Condition: Cancer

Investigator: Mark Heaney, MD, PhD

Status: Closed

This research study will test an investigational study drug called DCC-2618. This research study will explore the following: find the highest safe dose of DCC-2618, see how often DCC-2618 should be given, see how well research participants with cancer tolerate DCC-2618, and evaluate if DCC-2618 is effective against cancer. Cancers include: brain tumors,…

Study of Belantamab Mafodotin in Participants With Relapsed/Refractory Multiple Myeloma

Condition: Cancer / Multiple Myeloma

Investigator: Divaya Bhutani, MD

Status: Closed

Belantamab Mafodotin is a new therapy for patients with Multiple Myeloma. The drug works by combining chemotherapy and immunotherapy approach to treat Multiple Myeloma. The drug is a combination of an antibody against a target on plasma cells called BCMA and a chemotherapeutic agent called MMAF. The drug has shown activity in patients with late relapses of…

Evaluation of Fallopian Tube Cell Samples Collected by MAKO 7

Condition: Cancer / Gynecologic Cancer

Investigator: Jason Wright, MD

Status: Closed

The purpose of this study is to evaluate how accurately cells that are collected from the Fallopian tube can be categorized as benign or malignant. The MAKO 7 will be used to collect cell samples from the Fallopian tube. You are being asked to participate in the study because you are a woman who is undergoing a surgery to remove your Fallopian tubes and/or…

Study For Previously Treated Patients Of Multiple Myeloma Therapy Using Carfilozmib, Pomalidomide, and Dexamethasone

Condition: Cancer / Multiple Myeloma

Investigator: Suzanne Lentzsch, MD

Status: Closed

This is a research study for subjects who have been diagnosed with multiple myeloma, a cancer of plasmacells (a type of immune cell that produce antibodies) in the bone marrow, that has returned (relapsed) or has not responded (refractory) to your most recent treatment regimen.The subject's disease has also progressed after prior treatment with…

Study of Combination Treatment to Reduce Occurrence and Severity of Chronic Graft Versus Host Disease (GVHD)

Condition: Cancer / Leukemia

Investigator: Monica Bhatia, MD

Status: Closed

The purpose of this study is to compare two different combinations of treatment plans to a standard transplant procedure in order to see whether one or both of them are better at reducing the occurrence and severity of chronic GVHD. The research portion of this study involves manipulation of your stem cell product by removing T-cells, which cause chronic…

GSK3359609 Plus Tremelimumab for the Treatment of Advanced Solid Tumors (Non-small Cell Lung Cancer)

Condition: Cancer / Lung Cancer

Investigator: Brian Henick, MD

Status: Closed

This research study is being done to test the combination of two new drugs, GSK3359609 and Tremelimumab, in certain cancers. These two drugs are experimental which means they have not been fully tested yet and are not yet approved to treat any disease. There are two parts to this study. Part 1 determines the best dose for the study drugs and part 2 compares…

A study for patients with recurrent or metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) using study drug MEDI4736

Condition: Skin Cancer / Squamous Cell Carcinoma

Investigator: Sewanti Limaye, MD

Status: Closed

This study is for patients with recurrent or metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN). This study will test the safety of an experimental anti-cancer drug (MEDI4736). MEDI4736 is an antibody (a protein produced by the defense system of the body immune system) that has been made in the laboratory. MEDI4736 boosts the ability of your…

Implementation of a Prospective Financial Impact Assessment Tool in Patients with Metastatic Colorectal Cancer

Condition: Cancer / Gastrointestinal

Investigator: Alfred Neugut, MD, PhD

Status: Closed

Studies have shown that cancer patients may be at high risk for financial problems because of the cost of treatment. These financial problems can be stressful and sometimes might cause patients to avoid or refuse treatment. This study will measure how often financial problems happen in patients with colorectal cancer, using questionnaires that collect…

Study of TSR-042 and Niraparib in Treatment of Stage III or IV Epithelial Ovarian Cancer

Condition: Cancer / Gynecologic Cancer

Investigator: June Hou, MD

Status: Closed

This study is being done to determine if adding the investigational drugs (TSR-042 and niraparib) to standard of care treatment delays or prevents ovarian cancer recurrence (prevents the ovarian cancer from coming back).

A study for patients with previously untreated Multiple Myeloma

Condition: Cancer / Multiple Myeloma

Investigator: Divaya Bhutani, MD

Status: Closed

The purpose of this study is to find out how well Daratumumab works when it is given along with two other drugs called Lenalidomide and Dexamethasone compared to the drug combination of Lenalidomide and Dexamethasone to treat multiple myeloma.

Study of Durvalumab Following Chemoradiotherapy in Women with Locally Advanced Cervical Cancer

Condition: Cancer / Gynecologic Cancer

Investigator: Ana Tergas, MD

Status: Closed

AstraZeneca AB (AstraZeneca) is doing this research to find out if durvalumab, when given with chemoradiotherapy will help to treat cervical cancer.

A Study to Evaluate Immunotherapy Combinations in Participants With Lung Cancer

Condition: Cancer / Lung Cancer

Investigator: Catherine Shu, MD

Status: Closed

This research study is testing two potential new drugs called AB928 and AB122. AB928 is an investigational drug that has been shown in animal studies to improve the functioning of the immune system, without causing any immune effects on its own. This research study will help us understand whether AB928, the study drug, can be safely given in combination…

A study for patients with Acute Myeloid Leukemia (AML) using study drug atezolizumab and guadecitabine

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to test the safety of the combination of the experimental drugs called atezolizumab and guadecitabine (not yet approved by the U.S. Food and Drug Administration FDA or any other regulatory authority outside the United States) to find out what effects, good or bad, the combination of atezolizumab and guadecitabine has on patients…

Study of Radiation Therapy After Mastectomy

Condition: Cancer / Breast Cancer

Investigator: Eileen Connolly, MD, PhD

Status: Closed

This study is for women who have been diagnosed with stage 2 or stage 3 breast cancer whose doctor has recommended that you receive radiation therapy after your mastectomy to prevent your breast cancer from coming back. Radiation uses particles of energy to kill any remaining cancer cells where your breast was removed or in the lymph nodes. Radiation after…

Optical Tomographic Imaging in Pre-Surgical Women with Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Kevin Kalinsky, MD, MS

Status: Closed

Tomography (DOT), can help predict how well patients respond to a pre-surgical therapy. This imaging technique uses light to create 3D maps of the blood, fat, and water content of the breast. Based on these measurements taken over 2 time points during therapy (before and after), we will try to determine if this new imaging technique can use early…

Study of Dabrafenib, Trametinib, and Navitoclax in BRAF-Mutant Melanoma and Other Solid Tumors

Condition: Skin Cancer / Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of the first part (Phase I) of the study is to test the safety of navitoclax in combination with dabrafenib and trametinibat different doses to find out what effects, if any, it has on people. There will be about 18 people treated in this part of the study. The purpose of the second part of this study (Phase II) is to compare the good and bad…

A study for patients with Acute Myelogenous Leukemia using study drug ABT-199

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to evaluate the safety, and effectiveness of ABT-199 in combination with decitabine and ABT-199 in combination with azacitidine in subjects who have not been treated for their AML. In addition, substances (biomarkers) found in the blood and bone marrow that may indicate the effects or progress of the leukemia and the activity of…

Study of LY3321367 Alone or in Combination with LY3300054 in Patients with Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: Mark Stein, MD

Status: Closed

The main purpose of this study is to learn more about the study drug called LY3321367. The study wants to know more about the following: The safety of LY3321367 alone and in combination with another drug called LY3300054 and any side effects you might have Whether LY3321367 is tolerable when taken alone and in combination with LY3300054. How much…

A study for patients with recurrent or metastatic squamous cell carcinoma of the Head and Neck using study drug MEDI4736

Condition: Skin Cancer / Squamous Cell Carcinoma

Investigator: Sewanti Limaye, MD

Status: Closed

This study is for adult subjects with head and neck cancer (oral cavity, oropharynx middle part of the throat, hypopharynx bottom part of the throat, or larynx part of throat between the base of the tongue and the windpipe) that has either returned after treatment (recurrent) or is newly diagnosed. If newly diagnosed, the cancer must be metastatic,…

Study of Anti-Tumor Activity and Potential Predictors of Response in Patients with Melanoma (Advanced Mucosal or Acral Letiginous Melanoma)

Condition: Skin Cancer / Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this study is to find out which participants with melanoma respond best to nivolumab and ipilimumab treatment and to identify tumor and blood based markers that may predict response to the combination. This study is asking that participants submit tumor tissue samples from their initial tumor specimen and blood samples before they receive…

A Study of PSMA Targeted Genetically Modified Chimeric Antigen Receptor T Cells in Patients with Prostate Cancer

Condition: Cancer / Prostate Cancer

Investigator: Mark Stein, MD

Status: Closed

This research study is investigating a new treatment for cancer that uses your immune system (a type of white blood cell called T cells or T lymphocytes) to try to attack your cancerous cells. T cells fight infections, and may attack cancer cells, in some cases. Currently, your T cells may not able to attack your cancerous cells. The use of these modified T…

A study for patients with Acute Myeloid Leukemia (AML) using study drug decitabine

Condition: Cancer / Leukemia

Investigator: Richard Carvajal, MD

Status: Closed

This study is for patients with Acute Myeloid Leukemia (AML). The purpose of this study is to determine if decitabine plus JNJ-56022473 can be safely combined and is active for your disease. The study drugs used in this study are JNJ-56022473, an experimental drug and DACOGEN ( also known generic as decitabine), a drug already used to treat your type of…

Study of Experimental Drug in Patients with Acute Myeloid Leukemia (AML)

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to test the safety of DCLL9718S at different dose levels, alone or in combination with azacitidine. DCLL9718S is an experimental drug manufactured by Genentech that is designed to inhibit tumor growth. The drug is being tested in clinical trials and has not been approved by the U.S. Food and Drug Administration (FDA) and/or any…

Safety and Efficacy of Axicabtagene Ciloleucel and Rituximab or Lenalidomide in Participants With Refractory Large B-Cell Lymphoma

Condition: Cancer / Lymphoma

Investigator: Ran Reshef, MD

Status: Closed

The purpose of this study is to find out if the experimental product, axicabtagene ciloleucel, in combination with either rituximab or lenalidomide is safe and effective in treating lymphoma. Kite Pharma, Inc., (Kite) is the sponsor of this study. The sponsor is funding this research study and has also designed the trial. The sponsor is testing an…

A study for patients with chronic lymphocytic leukemia (CLL) using study drug TDR-1202

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

This study is being done to see how well tolerated the investigational drug TGR-1202 is in comparison to other similar therapeutics agents in treating patients with chronic lymphocytic leukemia (CLL).

Study of JCAR017 in Subjects with Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

The overall purpose of this part of the study is to determine the best dose of JCAR017 for treating adult participants with relapsed or refractory B-cell Chronic Lymphocytic Leukemia (CLL), and Small Lymphocytic Lymphoma (SLL) and to understand the side effects that participants with your disease may have when they are treated with JCAR017.

A study for patients with small cell lung cancer using study drug SGI-110

Condition: Cancer / Lung Cancer

Investigator: Catherine Shu, MD

Status: Closed

This study will investigate the safety and effectiveness of the study drug SGI-110 in combination with two immunotherapy drugs named durvalumab and tremelimumab in patients with small cell lung cancer who have progressed on other treatments. SGI-110 is a form of chemotherapy known as a "hypomethylating agent" and may help the immunotherapy work…

Study of Alvocidib When Administered in Sequence After Decitabine in Patients with Myeolodysplastic Syndromes (MDS)

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The purpose of this research study is to determine the preliminary safety and effectiveness (how well something works) of alvocidib when used after the standard drug decitabine in patients with MDS. The study will also gain information about the PK (the process by which a drug is absorbed, distributed, metabolized and eventually eliminated by the body),…

A study for patients with uveal melanoma using study drug AEB071

Condition: Cancer / Uveal Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this study is evaluate the benefits and safety of using the combination of drugs, AEB071 and BYL719 to treat patients with an advanced form of uveal melanoma. The study will have two parts. The first part twill test different dose levels of each drug.Once the highest safe dose level is found, another group of patients will be treated at that…

Study of RO7198457 in locally advanced or metastatic tumors

Condition: Cancer

Investigator: Brian Henick, MD

Status: Closed

The purpose of this study is to find out if the study treatment called RO7198457 (PCV) can be safely given to patients with cancer. PCV is a personalized cancer vaccine. Participants will either received PCV alone or in combination with atezolizumab.

Study for patients with Uveal Melanoma using study drug crizotinib

Condition: Cancer / Uveal Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of the treatment part of the study is to find out what effects drug crizotinib has, good and/or bad on people with "high risk" uveal melanoma after surgery or radiation for the eye. It is thought that giving crizotinib to patients with "high risk" uveal melanoma can lower the chance the cancer will come back. Uveal melanoma…

Study of EBV-Cytotoxic T Lymphocytes (EBV-CTLs) in Patients with Epstein-Barr Virus-Associated Viremia or Malignancies

Condition: Cancer / Lymphoma

Investigator: Ran Reshef, MD

Status: Closed

Epstein-Barr Virus (EBV) is the virus that causes mononucleosis, also known as mono. Almost all adults have had EBV. For most people, EBV never causes a health problem. However, when their immune system is not working properly (people who have had a transplant and those who have immune disorders), EBV can cause certain diseases where cells grow abnormally…

Palbociclib and Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)

Condition: Cancer

Investigator: Alice Lee, MD

Status: Closed

The purpose of this study is to find the best dose of Palbociclib that can be given safely with chemotherapy in children and young adults with Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL) which has come back or has not responded to standard therapy. Palbociclib is considered experimental because it has not been approved by the United…

A study for patients with B-Cell type diffuse large B-Cell Lymphoma using study drug CC-5013

Condition: Cancer / Lymphoma

Investigator: Owen O'Connor, MD, PhD

Status: Closed

This study will test the standard R-CHOP21 against R-CHOP21 plus lenalidomide. The purpose is to see whether adding lenalidomide works better and is as safe as R-CHOP by itself. This study is only for patients with ABC type DLBCL who have not yet been treated. Lenalidomide is not approved for use in DLBCL. Its use in this disease is experimental. In this…

HUDSON: Study of Multiple Treatments in Patients with Non-Small Cell Lung Cancer (NSCLC)

Condition: Cancer / Lung Cancer

Investigator: Catherine Shu, MD

Status: Closed

This is an open-label, Phase II study in patients with metastatic non-small cell lung cancer (NSCLC) whose cancer has gotten worse on an anti-programmed cell death-1/anti-programmed cell death ligand 1 (anti-PD-1/PD-L1) containing therapy. This study consists of a number of treatment cohorts to test the efficacy, safety, and tolerability of multiple…

A study for patients with advanced cancers such as Acute Myleoid Leukemia (AML) using study drug BAY 1251152

Condition: Cancer

Investigator: Mark Frattini, MD, PhD

Status: Closed

The purpose of this study is to identify the most appropriate dose that can be safely administered and that can have an effect on haematological cancer cells. BAY 1251152 works by obstructing a protein in your bodys cells called positive transcription elongation factor b (PTEFb) / cyclin-dependent kinase 9 (CDK9) pathway, which plays a role in the growth of…

Study of Therapy to Assess if it Reduces Risk of Cardiac Dysfunction in Patients with Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Katherine Crew, MD

Status: Closed

To assess whether prophylactic beta blocker therapy with carvedilol compared with no intervention reduces the risk of subsequent cardiac dysfunction in patients with metastatic breast cancer receiving trastuzumab-based HER-2 targeted therapy.

Antibodies against HIV

Condition: Infectious Disease / HIV

Investigator: Magdalena Sobieszczyk, Md

Status: Closed

We are testing two antibodies directed against HIV virus. The human body uses antibodies as one way to help fight infection.The antibodies are called VRC01LS and VRC07-523LS and they are given by IV infusion. Each participant will receive one dose by infusion. The main purpose of this study is to see if these two antibodies are safe and how a participants…

Study of Vaccine (GEN-009) in Adult Patient with Melanoma, NSCLC, Head and Neck Cancer, Bladder Cancer, or Kidney Cancer

Condition: Cancer

Investigator: Mark Stein, MD

Status: Closed

This is a research study for a vaccine called GEN-009. The main purpose of this study is to obtain information on the safety of GEN-009 and how it may activate the immune system to fight cancer. GEN-009 is a personalized vaccine. Each vaccine is made specifically for each person in the study. The vaccine is made after taking and testing cells from your…

A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS)

Condition: Cancer / Breast Cancer

Investigator: Dawn Hershman, MD

Status: Closed

This is a cohort study looking at the effects of anastrozole (an aromatase inhibitor) on patients, and specifically at Aromatose Inhibitor Musculoskeletal Symptoms (AIMSS). The genetic predictors of AIMSS will also be evaluated. Participants will take daily anastrazole and will be followed for 12 months. The study will enroll 35 patients at Columbia…

A Study of FT 2102 in Participants With Advanced Solid Tumors and Gliomas With an IDH1 Mutation

Condition: Cancer

Investigator: Fabio Iwamoto, MD

Status: Closed

This clinical trial will investigate an experimental drug called FT-2102. FT-2102 targets tumor cells that have an abnormal gene (code that tells your body what proteins to make), called isocitrate dehydrogenase 1 (IDH1). Research subjects with either a Hepatobiliary Cancer (HBC), a Chondrosarcoma, an Intrahepatic cholangiocarcinoma (IHCC), a Glioma, or…

A study for patients with select advanced cancers using study drug INCB24360

Condition: Cancer

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this study is to assess how safe and well tolerated study drugs, INCB24360 and nivolumab, are given in combination in patients who have advanced or metastatic solid tumors. The study will also assess how well INCB24360 in combination with nivolumab works in preventing disease progression in patients with melanoma (MEL), non-small cell lung…

Study of Drug vs. Placebo in Patients with Early Stage Non-Small Cell Lung Cancer (NSCLC)

Condition: Cancer / Lung Cancer

Investigator: Naiyer Rizvi, MD

Status: Closed

The purpose of this study is to determine if the study drug is safe and evaluate whether adjuvant therapy with the study drug will improve overall survival. The study drug is crizotinib (also known as XALKORI). The study will also collect tumor tissue and blood samples for future research.

A study for patients with advanced or metastatic solid tumors using study drug ulocuplumab combined with nivolumab

Condition: Cancer / Solid Tumors

Investigator: Naiyer Rizvi, MD

Status: Closed

This study is an open-label, multicenter phase 1/2 study. The study is designed in two parts, the first is designed to evaluate the safety of the study drug ulocuplumab in combination with nivolumab in subjects with small cell lung cancer (SCLC) and pancreatic adenocarcinoma (PAC). Subjects will receive a low dose of ulocuplumab in combination with…

Study of New Treatment for Non-Muscle-Invasive Bladder Cancer

Condition: Cancer / Bladder Cancer

Investigator: Joel DeCastro, MD, MPH

Status: Closed

The purpose of this study is to look at a new treatment for non-muscle-invasive bladder cancer. This new form of paclitaxel, a drug currently used by injection into a vein to treat various types of cancer, is designed to be instilled (injected) into the urinary bladder with a catheter (tube) placed into your bladder through your urethra (the opening where…

A study for patients with renal cell cancer using study drug sorafenib

Condition: Cancer

Investigator: Emerson Lim, MD

Status: Closed

The purpose of this study is to compare the effectiveness of tivozanib in renal cell cancer compared to an approved drug sorafenib which works in a similar way to tivozanib. Tivozanib and sorafenib are both called study medication. This study will also see whether tivozanib is safe and tolerable for patients with advanced renal cell cancer. This study will…

Study of Combinations of REGN2810, Chemotherapy, and Ipilimumab vs. Pembrolizumab Monotherapy in Patients with Non-Small Cell Lung Cancer

Condition: Cancer / Lung Cancer

Investigator: Naiyer Rizvi, MD

Status: Closed

This study is being done to determine if REGN2810 (anti-PD-1) in combination with ipilimumab (anti-CTLA-4) plus initial platinum-based doublet chemotherapy, or REGN2810 in combination with ipilimumab will prolong how long you live without your disease progressing compared to the standard of care pembrolizumab (anti-PD-1) monotherapy treatment. Neither…

Phase 3 Trial to Determine the Efficacy of Topical Hypericin combined with Fluorescent Light Therapy on Cutaneous T-Cell Lymphoma

Condition: Cancer / Lymphoma

Investigator: Larisa Geskin, MD

Status: Closed

This is a phase 3 clinical trial to determine the efficacy of topical SGX301 (synthetic hypericin) in combination with visible light therapy on cutaneous T-cell lymphoma (CTCL). Selected subjects can participate in 3 cycles each consisting of a 6 week treatment period where a chosen lesion will be treated with the study ointment (twice a week) followed by…

A study for patients with locally advanced or metastatic non-small cell lung cancer using study drug AZD9291

Condition: Cancer / Lung Cancer

Investigator: Naiyer Rizvi, MD

Status: Closed

The purpose of this study is to see if study drug AZD9291 is effective in treating non-small cell lung cancer (NSCLC) and if so, how it compares with chemotherapy. Only patients with NSCLC that has been confirmed as having the EGFR mutation are eligible to participate. Before patients can participate in the main study a tumor sample will be taken to check…

A study for patients with pancreatic cancer using study drug Olaparib

Condition: Cancer / Pancreatic Cancer

Investigator: Paul Oberstein, MD

Status: Closed

This research study is being conducted to see if a new treatment using a study drug called Olaparib given after platinum based chemotherapy treatments can reduce the risk of pancreatic cancer from growing back. Participants will receive either Olaparib or placebo (no contains active medication) and will stay on the research study for as long as they are not…

TrACER: Trial Assessing CSF Prescribing Effectiveness and Risk (TrACER) for Patients Receiving Chemotherapy

Condition: Cancer / Breast Cancer

Investigator: Dawn Hershman, MD

Status: Closed

This randomized clinical trial studies prophylactic colony stimulating factor management in patients with breast, colorectal or non-small cell lung cancer receiving chemotherapy and with risk of developing febrile neutropenia. Patients receiving chemotherapy may develop febrile neutropenia. Febrile neutropenia is a condition that involves fever and a low…

A study for patients with advanced cancer using study drug BAY 1251152

Condition: Cancer

Investigator: Emerson Lim, MD

Status: Closed

The purpose of the study is to evaluate the safety and tolerability of BAY 1251152 in patients with any type of solid tumors or non-indolent non-hodgkins lymphoma. The study will also investigate the pharmacokinetics (study of what the body does to the drug), as well as pharmacodynamics (study of what the drug does to the body), which may provide…

Study of Drug in Patients with Recurrent, Persistent or Metastatic Cervical Cancer

Condition: Cancer / Gynecologic Cancer

Investigator: Jason Wright, MD

Status: Closed

A Phase 2 Study of Atezolizumab (MPDL3280A) in Combination with Bevacizumab in Patients with Recurrent, Persistent or Metastatic Cervical Cancer. The purpose of this study is to test any good and bad effects of a combination of study drugs called atezolizumab and bevacizumab. The combination of atezolizumab and bevacizumab could shrink your cancer but it…

A study for patients with locally advanced or metastatic solid tumors using study drug demcizumab

Condition: Cancer / Solid Tumors

Investigator: Catherine Shu, MD

Status: Closed

The purpose of this study is to test the efficacy and safety of an experimental drug, demcizumab, when given in combination with pembrolizumab (Arm A of the study). Demcizumab is a humanized monoclonal antibody and was developed to target cancer stem cells. Demcizumab may block the growth of cancer stem cells, in addition to the remaining cancer cells, and…

Study of Drug E7777 in Cutaneous T-Cell Lymphoma - Cancer of T-lymphocytes (type of white blood cells) that Involves the Skin

Condition: Cancer / Lymphoma

Investigator: Larisa Geskin, MD

Status: Closed

The purpose of the Main study is to test the overall effects of E7777 on you and your illness. It is not known what effect E7777 will have on your illness or what the side effects will be. This study will look at the effect E7777 has on your body and your disease. It will also look at how your body absorbs, distributes, breaks down, and gets rid of the…

Study for Patients With PIK3CA-Mutant, Hormone Receptor-Positive, Her2-Negative, Locally Advanced or Metastatic Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Melissa Accordino, MD

Status: Closed

This a Phase III study designed to compare the efficacy and the safety of the triplet combination of GDC-0077 plus palbociclib and fulvestrant versus placebo plus palbociclib and fulvestrant in patients with PIK3CA-mutant, HR-positive, HER2-negative locally advanced or metastatic breast cancer whose disease progressed during treatment or within 12 months of…

Study of SY-1365 in Adult Patients with Advanced Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: June Hou, MD

Status: Closed

SY-1365 is an investigational drug that stops the function of a protein known as CDK7. Previous workhas shown that CDK7 is necessary for some cancers to grow. Therefore, SY-1365 could be used to slow down the growth of cancer. This research study is being done to understand the highest tolerated dose of SY-1365, and to assess the safety of SY-1365 in…

A new study for patients with Hodgkin's Lymphoma using study drug combination (brentuximab & bendamustine)

Condition: Cancer / Lymphoma

Investigator: Ahmed Sawas, MD

Status: Closed

The purpose of this study is to gather information about the effectiveness and safety of as drug called brentuximab vedotin when given in combination with another drug called bendamustine for Hodgkin Lymphoma. The study will assess the safety profile of the combination treatment and determine what proportion of patients achieve a complete remission.…

Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

Condition: Cancer / Lung Cancer

Investigator: Brian Henick, MD

Status: Closed

This purpose of this study is to determine whether the tumor cells of lung cancer patients contain changes to the DNA sequence of two proteins found on the cells surface- ALK and EGFR. If the tumor contains changes to the DNA of one of these proteins, the patient may be invited to participate on a trial that will look at drugs which may target tumors that…

18F-DCFPyL PET/CT in Men with Prostate Cancer

Condition: Cancer / Prostate Cancer

Investigator: Mark Stein, MD

Status: Closed

The purpose of this study is to see if 18FDCFPyL (PyL) PET/CT scans are able to find prostate cancer tumors. PyL is a radioactive drug (tracer) that targets prostate specific membrane antigen (PSMA). Because PSMA is a protein found mostly on the surface of prostate cancer cells, we are testing to see if PyL will be able to correctly identify prostate cancer…

A study for patients with advanced malignancies (glioma, heme and cholangiocarcinoma or other solid tumors) using study drug IDH305

Condition: Cancer / Solid Tumors

Investigator: Gary Schwartz, MD

Status: Closed

The purpose of this study is to learn whether IDH305 is safe and can have possible benefits for people diagnosed with glioma, cholangiocarcinoma, acute myeloid leukemia (AML), chondrosarcoma or other types of solid tumors and have IDH1R132-mutant tumors cancers that have the IDH1R132 mutation and are not getting better after treatment with currently…

Study of sertraline (Zoloft) with ara-C in combination in patients with acute myeloid leukemia (AML)

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The purpose of the study is to evaluate the safety, tolerability (the effect of the drug on your body), pharmacokinetics (the effect of your body on the drug) and maximum tolerated dose of sertraline in combination with cytosine arabinoside (ara-C, cytarabine) when given to patients with treatment-resistant myeloid leukemia. In addition, the effect of the…

A study for patients with advanced or metastatic soft tissue sarcoma using study drug Doxorubicin plus Olaratumab

Condition: Cancer

Investigator: Gary Schwartz, MD

Status: Closed

This study is for patients with metastatic or locally advanced soft tissue sarcoma (STS) who are not amenable to treatment with surgery or radiotherapy with curative intent. Patients will be treated with doxorubicin plus olaratumab versus doxorubicin plus placebo intravenously for 8 cycles. Patients without disease progression will be allowed to continue…

Study of Experimental Drug in Patients with Elevated Thrombocythemia (Too Many Platelets, Leading to Abnormal Blood Clotting or Bleeding)

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

The purpose of this study is to compare the safety, tolerability, and effectiveness of ruxolitinib, an investigational drug, compared to anagrelide, an FDA approved drug. Investigational means that the study drug has not been approved by the FDA for treatment of ET. Patients will be assigned to one of two groups. Group A will receive ruxolitinib and placebo…

Study of TAK-079 and Backbone Regimens in Patients with Newly Diagnosed Multiple Myeloma

Condition: Cancer / Multiple Myeloma

Investigator: Divaya Bhutani, MD

Status: Closed

This study will look to obtain information on the best dose of the research drug, TAK 079, when administered in combination with other approved multiple myeloma treatments for patients with newly diagnosed multiple myeloma. If you participate you will receive either Arm A (TAK-079 in combination with lenalidomide and dexamethasone) or Arm B (TAK-079 in…

Study of Imetelstat in Subjects With Myelodysplastic Syndrome (MDS)

Condition: Cancer / Leukemia

Investigator: Azra Raza, MD

Status: Closed

The purpose of the study is to evaluate the efficacy and safety of imetelstat for the treatment of patients with myelodysplastic syndrome (MDS). All patients participating in Part 1 of this study will get 7.5 mg/kg of imetelstat as a 2-hour intravenous infusion once every 4 weeks. The dose of imetelstat may be increased, held or decreased depending on how…

A study for patients with advanced cancers using study drug PEN-221

Condition: Cancer

Investigator: Antonio Fojo, MD, PhD

Status: Closed

This study is for patients with advanced cancers such as gastroenteropancreatic or lung or thymus or other neuroendocrine tumors or small cell lung cancer or large cell neuroendocrine carcinoma of the lung. This research study tests whether an experimental drug called PEN-221 may help people with before mentioned cancers. It is thought that PEN-221 might…

Study of MIW815 (ADU-S100) in Patients with Advanced/Metastatic Solid Tumors or Lymphomas

Condition: Cancer

Investigator: Matthew Ingham, MD

Status: Closed

The purpose of this study is to learn more about the study drug, MIW815 (ADU-S100). The study will identify the dose that can safely be given to people with solid tumors or lymphomas. The study will also see how well MIW815 (ADU-S100) works in people treated.

Using New Imaging Technique in Women with Breast Cancer to predict response to Neoadjuvant Chemotherapy

Condition: Cancer / Breast Cancer

Investigator: Dawn Hershman, MD

Status: Closed

This study examines diffuse optical tomography (DOT) as a way to monitor the progress of the breast cancer therapy. Specifically, it looks at DOTs ability to detect non-responders early in treatment and then adjust the therapy to improve response and overall survival. DOT is favorable to more conventional forms of cancer monitoring, such as physical exams,…

Study of LY3405105 for Patients with Advanced Solid Tumors

Condition: Cancer

Investigator: Gary Schwartz, MD

Status: Closed

This study will explore an investigational drug called LY3405105. "Investigational" means that the drughas not been approved by the United States Food and Drug Administration (FDA). The purpose of thisstudy is to learn about: Whether LY3405105 besylate can help study participants with advanced solid tumors; The safety of LY3405105 besylate and…

An observational study for women undergoing breast surgery using a laser therapy called Novilase

Condition: Cancer / Breast Cancer

Investigator: Bret Taback, MD

Status: Closed

The purpose of this study is to capture and evaluate clinical data about the long-term safety and effectiveness of Novilasee - a FDA-cleared minimally invasive treatment for benign breast tumors in hopes that tracking and analyzing the safety and effectiveness of Novilase in a real world application will benefit future patients and the breast cancer…

Study of Treatment Combinations in Patients with Metastatic Non-Small Cell Lung Cancer (NSCLC) (Morpheus-Lung)

Condition: Cancer / Lung Cancer

Investigator: Naiyer Rizvi, MD

Status: Closed

This study is being done to test the safety and efficacy of immunotherapy based treatment combinations in patients with metastatic non-small cell lung cancer. Participants will be assigned to one of two groups, Cohort 1 or Cohort 2. Each cohort will be split into Stage 1 and Stage 2 phases.

A study for patients with solid tumor and malignant lymphomas using study drug BAY 1143572

Condition: Cancer / Solid Tumors

Investigator: Gary Schwartz, MD

Status: Closed

The primary purpose of this research study is to evaluate the safety, tolerability and maximum tolerated dose of BAY 1143572. Moreover, concentrations of BAY 1143572 as well as of biomarker proteins may provide information about the effects of BAY 1143572, will be determined in blood and tumor tissue.

Study of Drug in Patients with Endometrioid Ovarian, Fallopian Tube, or Primary Peritoneal Cancer who Have Received Prior Chemotherapy

Condition: Cancer / Gynecologic Cancer

Investigator: Jason Wright, MD

Status: Closed

The LIGHT study is a clinical research study for women who have been diagnosed with ovarian cancer. The purpose of the study is to evaluate the safety and effectiveness of an investigational drug in women with this type of cancer, using genetic information to evaluate tumors.

A study for patients with soft tissue sarcoma using study drug olaratumab

Condition: Cancer

Investigator: Gary Schwartz, MD

Status: Closed

The purpose of this study is to find out how safe study drug olaratumab given with gemcitabine and docetaxel is for patients and whether olaratumab given with gemcitabine and docetaxel can help patients with advanced or metastatic soft tissue sarcoma (STS).

Testing Computer Tools to Improve Prostate Cancer Decisions

Condition: Cancer / Prostate Cancer

Investigator: Joel DeCastro, MD, MPH

Status: Closed

This research study will look at whether computer tools (also called decision aids) help prostate cancer patients better understand their treatment options and help patients talk about their treatment preferences with their doctors

A study for patients with advanced melanoma using study drug Talimogene Laherparepvec

Condition: Skin Cancer / Melanoma

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this study is to find out more about the Amgen agent called talimogene laherparepvec in people with advanced melanoma when given in combination with another drug developed by Merck called pembrolizumab. Melanoma is a type of skin cancer. Advanced melanoma means the tumor is not removable by surgery or has spread to other parts of the body.

A study for patients with Cutaneous T-Cell Lymphoma/Mycosis Fungoides using topical lotion Naloxone in the treatment of itching

Condition: Cancer / Lymphoma

Investigator: Larisa Geskin, MD

Status: Closed

You are being asked to participate in a research study because you have Cutaneous T-Cell Lymphoma/Mycosis Fungoides, and one of your symptoms is itching. This study is being done to assess the efficacy and safety of Naloxone HCL Lotion 0.5% compared to Vehicle Lotion for the treatment of itching in patients with mycosis fungoides (MF) which is a type of…

MLN4924 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome (18 to 21 years old)

Condition: Cancer / Leukemia

Investigator: Luca Szalontay, MD

Status: Closed

The purpose of this study is to find the best dose of pevonedistat that can be given safely with chemotherapy in young adults with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) that has either come back or has not responded to the standard therapy. Pevonedistat works by blocking some of the enzymes that are needed for cell growth.

A study for patients with ovarian cancer using biomarker HE-4 to predict recurrence

Condition: Cancer / Gynecologic Cancer

Investigator: Jason Wright, MD

Status: Closed

The purpose of this study is to find out if the study drug, HE4 has the potential to improve performance of biomarker CA 125 to determine recurrence of epithelial ovarian cancer before detecting the cancer clinically, surgically or through radiological scans. HE4 (Human Epididymis Protein 4) is a biomarker expressed in the normal lining of the female…

Study to Evaluate Novel Combination Therapies in Subjects with Previously Treated EGFRm NSCLC

Condition: Cancer / Lung Cancer

Investigator: Catherine Shu, MD

Status: Closed

The purpose of this study is to look at whether the combination of MEDI9447 and osimertinib or MEDI9447 and AZD4635 will improve the outcome in subjects with advanced epidermal growth factor receptor mutant (EGFRm) non-small cell lung cancer (NSCLC).

Study for patients with metastatic melanoma receiving therapy with Keytruda using imaging techniques to observe change in tumor size

Condition: Cancer / Multiple Myeloma

Investigator: Yvonne Saenger, MD

Status: Closed

The purpose of this study is to test two imaging techniques, one called whole body diffusion weighted magnetic resonance imaging (WB-DWI MRI), and another called F-18 3-deoxy-3-fluorothymidine PET (F-18-FLT PET). The goal is to see whether these imaging techniques would allow the study doctors to see changes in the size of a tumor earlier for patients with…

Study of Drug for the Treatment of Pancreatic Cancer

Condition: Cancer / Pancreatic Cancer

Investigator: Karie D. Runcie, MD

Status: Closed

The purpose of this study is to find out which doses of talimogene laherparepvec (T-Vec) can be given safely to patients with pancreatic cancer that is either too big to be taken out by surgery or has spread to other parts of the body. The study will also see if T-Vec can cause tumor shrinkage or prevent its growth. To find out which doses are safe, all…

A study for women with invasive breast cancer or DCIS undergoing mastectomy using study drug Faslodex

Condition: Cancer / Breast Cancer

Investigator: Sheldon Feldman

Status: Closed

The main purpose of this study is to determine the safety and tolerability of Faslodex given directly into thebreast ducts of women with invasive breast cancer or Ductal Carcinoma In Situ (DCIS). This study is for women who have been diagnosed with invasive breast cancer or DCIS. DCIS is the presence of abnormal cells inside a milk duct in the breast, and…

NKTR-214 in Combination with Pembrolizumab or Atezolizumab in Patients with Advanced or Metastatic Cancer (NSCLC, Bladder, or Melanoma)

Condition: Cancer / Solid Tumors

Investigator: Mark Stein, MD

Status: Closed

The purpose of this study is to test the safety, tolerability, and effectiveness (how well these drugs work together) of NKTR-214 given in combination with KEYTRUDA or TECENTRIQ. We want to find out what effects, good or bad, the study drug has on the body and cancer when combined with KEYTRUDA or TECENTRIQ. The study will recruit participants at least 18…

Pre-Surgical Trial of Sombination of Combination of Metformin and Atovastatin in Newly Diagnosed Operable Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Kevin Kalinsky, MD, MS

Status: Closed

The purpose of this study is to determine the effects of combining metformin and atorvastatin treatment in patients with newly diagnosed breast cancer during the interval between breast biopsy and surgery. Metformin is a common treatment for patients with diabetes, and atorvastatin is a common therapy for elevated cholesterol. We will examine the effects of…

Study of Platinum and Etoposide vs. Temozolomide and Capecitabine in Patients With Advanced Gastroenteropancreatic Neuroendocrine Cancer

Condition: Cancer

Investigator: Antonio Fojo, MD, PhD

Status: Closed

The purpose of this study is to compare the effects, both good and bad, of the study drugs temozolomide and capecitabine to the usual chemotherapy treatment for this disease of cisplatin or carboplatin (referred to as platinum therapy) and etoposide. Usually the first treatment given for this cancer is platinum therapy and etoposide. The chemotherapy drugs…

A study for patients with advanced refractory solid tumors using study drug Varlilumab

Condition: Cancer / Solid Tumors

Investigator: Fabio Iwamoto, MD

Status: Closed

The purpose of this research study is to test the effectiveness (how well the drug works), safety, and tolerability varlilumab and nivolumab (investigational drugs) together in patients with advanced solid tumors. Varlilumab and nivolumab are antibodies (types of human protein) that are manufactured in a laboratory and are being tested to see if they will…

Study of Drug in Patients with Advanced Solid Tumor Malignancies

Condition: Cancer

Investigator: Richard Carvajal, MD

Status: Closed

This is a phase 1/1b research study for adults with a diagnosis of an advanced solid tumor for which there are no standard therapies beyond those that may have already been received. This study involves an investigational (experimental) drug called MGCD516. Investigational means that MGCD516 is not approved by the U.S. Food and Drug Administration (FDA).…

Radiation and Immune Checkpoints Blockade in Metastatic Non-Small Cell Lung Cancer (NSCLC)

Condition: Cancer / Lung Cancer

Investigator: Brian Henick, MD

Status: Closed

The purpose of this study is to test whether local radiotherapy combined with Ipilimumab is safe. The study will try to find out if it can help patients with metastatic non-small cell lung cancer better than treatment with Ipilimumab and Nivolumab alone.

A study for women who are undergoing breast reconstruction surgery using a new device called the AeroForm Tissue Expander System

Condition: Cancer / Breast Cancer

Investigator: Jeffery Ascherman, MD

Status: Closed

The purpose of this study is to assess the performance and ease of use of the AeroDorm Tissue Expander System in women who are undergoing breast reconstruction surgery. This device is for use in women who are having or have had a mastectomy procedure to remove their breast(s) because of breast cancer (or to decrease their risk of breast cancer). The study…

Study of Diagnostic Tests for Prostate Cancer

Condition: Cancer / Prostate Cancer

Investigator: Sven Wenske, MD

Status: Closed

This study is being conducted to evaluate the performance of the ConfirmMDx and SelectMDx tests for Prostate Cancer to identify patients with increased risk for clinically significant disease, to ultimately lower the rate of repeat biopsies. Approximately 1000 people are expected to take part in this study.

Assessing Financial Difficulty in Patients with Blood Cancers (Chronic Lymphocytic Leukemia and/or Multiple Myeloma)

Condition: Cancer

Investigator: Suzanne Lentzsch, MD

Status: Closed

The purpose of this study is to measure how often financial problems happen in patients with chronic lymphocytic leukemia or multiple myeloma, using questionnaires that collect information about finances and quality of life. In order to get a full picture of the financial impact of chronic lymphocytic leukemia and multiple myeloma, we also want to collect…

A study for patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome using study drugs FT 2102

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to test the safety and effectiveness of an experimental medication, FT-2102, in the treatment of acute myeloid leukemia or myelodysplastic syndrome. Patients will receive either FT-2102 alone or in combination with cytarabine or azacitidine, an approved drug commonly used in the treatment of AML and MDS. Subjects will remain on…

Study of Alvocidib in Patients with Relapsed/Refractory Acute Myeloid Leukemia Following Treatment with Venetoclax Combination Therapy

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

You are being asked to take part in this study because you have acute myeloid leukemia (AML) that has come back after initial treatment (relapsed) with venetoclax combination therapy or because you did not get a complete response from your initial treatment (refractory) with venetoclax combination therapy. The purpose of this research study is to determine…

A study for patients with solid tumors or lymphoma using study drug LY3039478

Condition: Cancer

Investigator: Nicole Lamanna, MD

Status: Closed

This study is being done to see how safe an investigational drug (LY3039478) is and how well it will work to help people with advanced or metastatic cancer including solid tumors or lymphoma (cancerous growth of lymphoid tissue) including chronic lymphocytic leukemia (CLL blood cell cancer). The primary purpose of your participation in this study is to help…

The ABC Trial: Study of Aspirin as Adjuvant Therapy for HER2 Negative Breast Cancer

Condition: Cancer / Breast Cancer

Investigator: Dawn Hershman, MD

Status: Closed

This randomized phase III trial studies how well aspirin works in preventing the cancer from coming back (recurrence) in patients with human epidermal growth factor receptor 2 (HER2) breast cancer after chemotherapy, surgery, and/or radiation therapy. Aspirin is a drug that reduces pain, fever, inflammation, and blood clotting. It is also being studied in…

A study for patients with acute myeloid leukemia using study drug Venetoclax in combination with Azacitidine

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The purpose of this study is to evaluate the efficacy (how well the study drug works) and safety of venetoclax in combination with azacitidine in subjects who have not been treated for their acute myeloid leukemia (AML). The tolerability (the degree to which evident adverse effects can be tolerated by the patient) of venetoclax will also be evaluated.

Study to Evaluate Monotherapy and Combination Immunotherapies in Participants With PD-L1 Positive Non-small Cell Lung Cancer (ARC-7)

Condition: Cancer / Lung Cancer

Investigator: Brian Henick, MD

Status: Closed

The purpose is to study the safety and the effect of AB122, AB154, and AB928 in participants with stage IV non-small cell lung cancer. Researchers will study the treatment response of AB122 alone as well as in combination with AB154 and AB928. There are three possible groups a participant can be randomly assigned to. Group 1 will include AB122 alone, Group…

Study of Chemotherapy alone, Chemotherapy plus Nivolumab or Nivolumab and BMS-986205 in Participants with Muscle-Invasive Bladder Cancer

Condition: Cancer / Bladder Cancer

Investigator: Emerson Lim, MD

Status: Closed

The purpose of this study is to test how well the drug works, safety, and side effects of the experimental drug called BMS-986205. BMS-986205 will be added to another cancer medicine called nivolumab plus chemotherapy for participants who have bladder cancer that has grown into the muscle wall of the bladder. These drugs will be compared to just…

A study for patients with advanced non-small cell lung cancer using study drug Alectinib

Condition: Cancer / Lung Cancer

Investigator: Sewanti Limaye, MD

Status: Closed

The purpose of this study is to compare the effects, good or bad, of drugs alectinib and crizotnib on patients with lung disease to find out which is better for patients with a special type of non-small cell lung cancer (NSCLC) that is called anaplastic lymphoma kinase (ALK)-positive NSCLC. In this study, participants will receive either alectinib or…

A Study Evaluating the Safety and Pharmacokinetics of Atezolizumab Administered With Hu5F9-G4 to Patients With Acute Myeloid Leukemia

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The main purposes of this study are to: 1) understand the safety of atezolizumab given in combination with Hu5F9-G4 and 2) understand the way the body processes atezolizumab and Hu5F9-G4 (pharmacokinetics). This study will also be testing if the combination therapy is effective at treating relapsed or refractory acute myeloid leukemia (R/R AML).…

A dose escalation study of trial drug PF-06650808 in patients with advanced solid tumors

Condition: Cancer / Solid Tumors

Investigator: Richard Carvajal, MD

Status: Closed

The purpose of this research study is to learn about the safety and effectiveness of the study drug, PF-06650808, when given as a single agent and to find the best dose for treating cancer. Prior to this study, PF-06650808 has never been given to people. PF-06650808 is known as an antibody drug conjugate. A toxic agent is chemically linked to an antibody.…

Study for Patients with Urothelial Carcinoma that is Unresectable or Metastatic/Recurrent

Condition: Cancer

Investigator: Mark Stein, MD

Status: Closed

The purpose of this clinical trial is to evaluate safety of the trial treatment, its effects on the immune system and on urothelial cancer. The trial treatment includes INO-5401 + INO-9012 delivered by electroporation in combination with TECENTRIQ (Atezolizumab). INO-5401 + INO 9012 is a DNA based therapy that has been created in a lab using the DNA…

Safety, Tolerability and Pharmacokinetics of an Anti-PD-1 Monoclonal Antibody in Subjects With Advanced Malignancies

Condition: Cancer / Sarcoma

Investigator: Gary Schwartz, MD

Status: Closed

The purpose of this study is to determine if the study drug toripalimab is safe, to determine future doses to give to patients with cancer, and to measure the amount of toripalimab in the blood. Up to approximately 240 subjects will be enrolled in Part B. The dose given in Part B will be 240 mg. The dose was chosen based upon safety data obtained from…

A study for patients with advanced unresectable dedifferentiated liposarcoma (DDLS) using study drug Selinexor

Condition: Cancer / Solid Tumors

Investigator: Gary Schwartz, MD

Status: Closed

This is a Phase 2-3 study evaluating the effects of selinexor in patients with advanced unresectable dedifferentiated liposarcoma (DDLS). This study drug selinexor works by trapping tumor suppressing proteins within the nucleus of the cells and thus causing the cancer cells to die or stop growing. Selinexor has previously been tested in humans to define a…

A study for patients with bladder cancer using study drug Vincinum

Condition: Cancer

Investigator: Joel DeCastro, MD, MPH

Status: Closed

This study is designed to obtain information on the safety and the effectiveness of an experimental drug called Vicinium when it is given to human subject(s)/participant(s) with bladder cancer that has not spread to the muscle of the bladder. Vicinium is part of an antibody connected to a protein that can kill cells. The protein is a modified pseudomonas…

Study: Drug and Device Combination for Treatment HPV16 and/or HPV18 Related High Grade Squamous Intraepithelial Lesion (HSIL) of Cervix

Condition: Cancer / Gynecologic Cancer

Investigator: Ana Tergas, MD

Status: Closed

The purpose of this study, which involves research, is being done to see how well an investigational new drug and study device combination will work to treat people with pre-cancerous cells on the cervix caused by human papillomavirus (HPV). The treatment combination is testing a drug, called VGX-3100, given by injection and used with the study device,…

ADI-PEG 20 in Combination With Gemcitabine and Docetaxel for the Treatment of Bone and Soft Tissue Sarcoma

Condition: Cancer / Sarcoma

Investigator: Gary Schwartz, MD

Status: Closed

The purpose of this research study is to learn more about adding the drug ADI-PEG 20 to a standard treatment regimen called gem-tax (the chemotherapy drugs gemcitabine and docetaxel) for subjects with bone and soft tissue sarcoma, and how the addition of ADI-PEG 20 affects the tumors response to treatment and the side effects you experience.

Study of SPL-108 Injections Used in Combination with Paclitaxel in Patients with Advanced Ovarian Epithelial Cancer

Condition: Cancer / Gynecologic Cancer

Investigator: June Hou, MD

Status: Closed

The purpose of this study is to determine whether SPL-108 injection might be useful for the treatment of ovarian cancer. The study will evaluate whether SPL-108 can slow the growth and spread of cancerous cells in your body. If you agree, you will be treated with SPL-108 injection in combination with paclitaxel and we will collect blood and tissue samples…

A study for patients with recurrent or metastatic squamous cell carcinoma of the head and neck using study drug MEDI4736

Condition: Skin Cancer / Squamous Cell Carcinoma

Investigator: Sewanti Limaye, MD

Status: Closed

The purpose of this study is to determine the effectiveness and safety of study drug MEDI4736 monotherapy, tremelimumab monotherapy, and MEDI4736 and tremelimumab combination therapy in the treatment of patients with recurrent or metastatic PD-L1-negative squamous cell carcinoma of the head and neck who have progressed during or after treatment with…

Semi-Structured Interviews with Patients about Chemotherapy-Induced Peripheral Neuropathy (CIPN)

Condition: Cancer

Investigator: Dawn Hershman, MD

Status: Closed

Aim 1: To describe the perceptions and experiences of CIPN by patients. 1. To describe the terminology used by patients to describe CIPN.; 2. To describe the effects that CIPN has on patients' day-to-day quality of life.; 3. To describe how patients communicate with their healthcare providers about CIPN, and what barriers may interfere with this…

Genetic Analysis of Blood and Tissue Samples From Participants With Advanced Cancer

Condition: Cancer

Investigator: Matthew Ingham, MD

Status: Closed

Major advances are being made in the treatment of cancer. One such advance involves the use of targeted treatments designed to work against specific molecular alterations in a given patients tumor. However, in most cases, we are not yet able to predict which patients will benefit from a specific targeted treatment, even if a tumor harbors the alteration…

A study for patients with Metastatic Castration-resistant Prostate Cancer (mCRPC) using study drug JNJ-56021927

Condition: Cancer / Prostate Cancer

Investigator: Edward Gelmann, MD

Status: Closed

The purpose of this study is to compare the clinical benefit (i.e., does it help to improve or slow down the cancer) of adding study drug JNJ-56021927 to combined treatment of abiraterone acetate plus prednisone to treat patients with metastatic Castration-resistant Prostate Cancer (mCRPC). This study will also evaluate the possible side effects of study…

Study of the Effects of Drug in Conjunction with Hormone Therapy in Patients with Endometrial Carcinoma

Condition: Cancer / Gynecologic Cancer

Investigator: June Hou, MD

Status: Closed

The purpose of this study is to compare the effects of using Sodium Cridanimod in combination with the progestin (hormone therapy) megestrol acetate. Hormonal therapy on its own is generally not aneffective treatment for endometrial cancer when there are not have enough progestin receptors on tumor cells. The addition of the study drug Sodium Cridanimod…

Study of ADU-S100 and Pembrolizumab in Head and Neck Cancer

Condition: Cancer / Head and Neck Cancer

Investigator: Matthen Mathew, MD

Status: Closed

The purpose of this study is to study ADU-S100 and pembrolizumab in patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC). This study aims to evaluate how safe and effective this drug combination is at treating your cancer. These drugs are thought to work by interacting with your immune system to in order to more effectively…

Tazemetostat in Combination With Doxorubicin as Therapy for Advanced Epithelioid Sarcoma

Condition: Cancer / Sarcoma

Investigator: Matthew Ingham, MD

Status: Closed

The purpose of this study is to learn about the effects, safety, and proper dosage of tazemetostat in combination with doxorubicin for the treatment of soft tissue sarcoma. Doxorubicin is a common therapy for soft tissue sarcoma, but is not FDA approved in combination with tazemetostat. This study treatment combination may suppress or prevent tumor growth…

A study for women with breast cancer using a microfluidic device to detect leptomenigeal metastasis (LM)

Condition: Cancer / Breast Cancer

Investigator: Kevin Kalinsky, MD, MS

Status: Closed

This study is for women with breast cancer who will be undergoing lumbar puncture to evaluate for the presence of leptomeningeal metastasis, a complication in which the cancer spreads to the membranes (meninges) surrounding the brain and spinal cord. This condition is typically diagnosed by examining the cerebrospinal fluid obtained from the lumbar puncture…

Study of Sacituzumab Govitecan in patients with triple-negative breast cancer

Condition: Cancer / Breast Cancer

Investigator: Kevin Kalinsky, MD, MS

Status: Closed

The purpose of this study is to determine the effectiveness of the study drug, sacituzumab govitecan, to the treatment of physicians choice, in patients with metastatic, triple negative breast cancer.

Study of Avapritinib (BLU-285) in Patients with Indolent Systemic Mastocytosis (ISM) or Smoldering Systemic Mastocytosis (SSM)

Condition: Cancer

Investigator: Mark Heaney, MD, PhD

Status: Closed

This research study is a 3-part, randomized, double-blind study designed to learn more about the safety and effectiveness of an experimental drug called avapritinib (formerly called BLU-285), when given to individuals who have been diagnosed with Indolent Systemic Mastocytosis (ISM) or Smoldering Systemic Mastocytosis (SSM). Experimental means it is not yet…

A study for patients with advanced skin cancer of the head and neck, lung or esophagus using study drug Selinexor (KPT-330)

Condition: Cancer / Skin Cancer

Investigator: Sewanti Limaye, MD

Status: Closed

The purpose of this study is to examine the effects of KPT-330 on patients with an advanced form of skin cancer called Squamous Cell Cancer (SCC) of the head and neck, lung, or esophagus. The study drug KPT-330 is an investigational drug that

Study of Study Drug MGD009 in Patients with Prostate Cancer

Condition: Cancer / Prostate Cancer

Investigator: Charles Drake, MD

Status: Closed

A study for women with ovarian cancer using study drug lurbinectedin

Condition: Cancer / Gynecologic Cancer

Investigator: Ana Tergas, MD

Status: Closed

The main aim of this clinical trial is to know the effects (good or bad) that study drug lurbinectedin (PM01183), has on women with ovarian cancer. Lurbinectedin (PM01183), is an investigational drug. This means that the drug has not been approved by the Food and Drug Administration (FDA) for medical use in patients, but has only been approved for use in…

Study of Drug in Patients with Abdominal Neuroendocrine Tumors

Condition: Cancer

Investigator: Antonio Fojo, MD, PhD

Status: Closed

You are being asked to participate in this study because you have a neuroendocrine tumor that has spread to your organs. You may or may not have had prior treatment for your neuroendocrine tumor. The purpose of this study is to determine if a drug called entinostat has efficacy in shrinking neuroendocrine tumors. People who usually have metastatic…

Study of Drug in Non-Small Cell Lung Cancer

Condition: Cancer / Lung Cancer

Investigator: Naiyer Rizvi, MD

Status: Closed

The purpose of this study is to test the safety of the study drugs and how well your body tolerates it. The study will also test how well the study drugs work to slow down the growth of you tumor or stop your cancer. The study drugs are Cergutuzumab Amunaleukin and Atezolizumab. Atezolizumab is FDA approved for the treatment of patients with metastatic non-…

A study for patients a with inoperable advanced bile duct cancer using photodynamic therapy (PDT)

Condition: Cancer

Investigator: Francis Gress, MD

Status: Closed

The study aims to assess the effect of porfimer sodium with PDT administered with medical standard ofcare compared to medical standard of care alone on the overall survival time of patients with bile duct cancer and its effect on cholestasis (blocked bile flow), time-to-treatment failure, performance status, and health-related quality of life.

Study of Drug in Patients with Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

The main goal of this study is to find out about how duvelisib acts in patients with CLL/SLL who were previously treated with a BTKi (Bruton Tyrosine Kinase inhibitor - commercially available ibrutinib or another investigational BTKi). Duvelisib is an investigational drug, meaning that it is not FDA approved, designed to try to stop cancer growth by…

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Medical Condition