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Displaying 1 - 71 of 71

3D Ultrasound Imaging of the Eye

Condition: Healthy Volunteers
Investigator: Ronald Silverman, PhD
Status: Currently Recruiting
The Department of Ophthalmology is conducting an NIH-funded study of vitreous floaters. Adults with or without floaters will be qualified for this study. We are specifically interested in myopes (nearsighted people) and diabetics as well as candidates for cataract surgery in addition to normal subjects. The study will involve routine measurements of axial…
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HPTN 103/ Purpose 4: An HIV Prevention Study for People Who Inject Drugs

Condition: Healthy Volunteers
Investigator: Ellen Morrison, MD, MPH
Status: Currently Recruiting
PrEP (Pre-Exposure Prophylaxis) is medication that is taken to prevent HIV if a person is exposed to HIV. Research is ongoing to develop PrEP medications that may be both convenient and effective. This study is important because people who inject drugs face multiple overlapping individual, social, legal, and structural challenges contributing to a…
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Studies of Behavior and Cognition (Healthy Volunteers)

Condition: Healthy Volunteers
Investigator: Kiyohito Iigaya, PhD
Status: Currently Recruiting
Our lab is conducting a series of research studies investigating people's behavior. We are looking for people between the ages of 18 and 60. As a healthy study participant, you will be asked to complete a set of self-report questionnaires probing demographics and personality traits, followed by a number of computer-based tasks. Study participants earn…
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Study of People with First-Degree Relatives (Parents, Siblings, Children) with Multiple Sclerosis

Condition: Healthy Volunteers
Investigator: Philip De Jager, PhD
Status: Currently Recruiting
Genes and Environment in MS (GEMS) is a longitudinal cohort study investigating how genetics and environment can lead to the onset of Multiple Sclerosis. We are recruiting first-degree relatives (siblings, parents, and children) of people who have been diagnosed with MS. This study involves the collection of magnetic resonance imaging (MRI) of the brain,…
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Nutrition Study

Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Currently Recruiting
We are currently looking for healthy, nonsmoking adults ages 25-65yrs who are dissatisfied with their sleep to participate in a sleep study. Participants should find their sleep not refreshing but not taking external sleep aids. Participants must be willing to eat different foods for two periods of 4 days and undergo testing over a 24-hour period at the…
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Bilingual Study

Condition: Healthy Volunteers
Investigator: Marla Hamberger, PhD
Status: Currently Recruiting
The purpose of this project is to develop a set of word finding or "naming" tests for Bilingual English-Spanish speakers, ages 16-85. The main tasks involve naming pictures of common objects (e.g. broom) or naming items when given a description (e.g. "what children ride to school in"). There are some other tasks as well such as single…
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The CORCINCH-HF Study: Study of AccuCinch in Patients with Symptomatic Heart Failure with Reduced Ejection Frraction (HFrEF)

Condition: Heart Disease / Heart Failure
Investigator: Gabriel Sayer, MD
Status: Currently Recruiting
This is a prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Repair System in patients with heart failure and reduced ejection fraction (HFrEF).
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The Lifespan Study

Condition: Healthy Volunteers
Investigator: Michael Lipton, MD PhD
Status: Currently Recruiting
The Lifespan Study uses neuroimaging, cognitive tests, and genomics to explore how the brain's structure and function change throughout life. We are creating a database of typical brain imaging data to study age-related changes. This database will support research, clinical studies, and the creation of new tools for measuring brain health. The Lifespan…
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DUO: Mobile Health tool Focus Groups to support HIV PrEP among Young Latino/e/x Cisgender Men and nonbinary Persons assigned Male at birth

Condition: Healthy Volunteers
Investigator: Ellen Morrison, MD, MPH
Status: Currently Recruiting
Come and talk with us about HIV prevention! HPTN 113-01/DUO is a series of 3 focus group discussions with young Latino/e/x cisgender men and gender nonbinary persons assigned male at birth (AMAB), who have sex with men. The focus groups will be conducted in English or Spanish, include 5-10 people, and be audio-recorded. Participants will be asked to give…
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APOLLO Trial for patients with Mitral regurgitation

Condition: Heart Disease / Valve Disease
Investigator: Susheel Kodali, MD
Status: Currently Recruiting
This is designed for patients with severe, symptomatic mitral regurgitation who are not candidates for conventional mitral repair.
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Clinical Study of the Edwards Cardioband FIT Valve Repair System

Condition: Valve Disease / Tricuspid Valve Disease
Investigator: Susheel Kodali, MD
Status: Currently Recruiting
The Edwards Cardioband Tricuspid Valve Reconstruction FIT valve repair system is a prospective, single arm, multi-center study to evaluate the safety and performance of the Cardioband Tricuspid System. The Edwards Cardioband Tricuspid Valve Reconstruction System is intended for patients with tricuspid regurgitation deemed to be potential candidates for…
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ALIGN AR-HDE: JenaValve Pericardial TAVR Aortic Regurgitation Study

Condition: Valve Disease / Aortic Valve Disease
Investigator: Torsten Vahl, MD
Status: Currently Recruiting
The objective of the study is to evaluate the safety and efficacy of the JenaValve Pericardial TAVR system when treating patients with aortic regurgitation. Aortic Regurgitation is a condition that develops when the heart's aortic valve does close tightly, therefore the blood leaks back into the heart chamber. The JenaValve Pericardial TAVR system will…
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COMPLETE TAVR

Condition: Heart Disease
Investigator: Vivian Ng, MD
Status: Currently Recruiting
The purpose of this study is to find out, in patients with CAD who had successful TAVR with a balloon expandable heart valve, whether restoring blood flow to all blocked or narrowed arteries via PCI using coronary stents (metal scaffold) is better than treating the coronary artery disease with medications only following TAVR. The study will also compare…
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Meal Timing Study (20-49 Yrs)

Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Currently Recruiting
The overall goal of this project is to determine whether the timing of your meals influences health. We are currently looking for healthy, non-smoking, men and women to participate in this study. You must regularly sleep at least 7-9 hours/night and regularly eat close to wake time. In addition, you must be willing to come to Columbia University Irving…
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Study to test how brain circuits may cause auditory hallucinations

Condition: Healthy Volunteers
Investigator: Guillermo Horga, MD, PhD
Status: Currently Recruiting
In this study, we are trying to learn more about the symptoms of schizophrenia, specifically to learn how abnormalities in the brain may produce certain experiences that are common in patients with schizophrenia. The study involves clinical interviews, clinical chart review, computer tests, and magnetic resonance imaging (MRI) scans. The study will be…
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REACT-AF: Evaluation of Blood-Thinning Medication in Patients with Atrial Fibrillation (AF)

Condition: Heart Disease
Investigator: Angelo Biviano, MD, MPH
Status: Currently Recruiting
The purpose of this study is to assess whether it is safe and effective to stop oral anticoagulation medication (a blood-thinning medication) during prolonged periods of normal heart rhythm in participants with infrequent episodes of atrial fibrillation (AF). Atrial fibrillation (AF) is the most common abnormal heart rhythm and is associated with an…
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Designing an intervention to reduce heart disease risk among transgender and gender diverse adults

Condition: Heart Disease
Investigator: Billy Caceres, PhD, RN
Status: Currently Recruiting
The purpose of this study is to explore sources of stress, stress management techniques, and health behaviors associated with heart disease risk among transgender and gender diverse adults (ages 35 to 64 years). We also hope to identify preferences for an intervention to reduce heart disease risk among transgender and gender diverse adults. Participants…
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Study of Cuffless Upper Arm Ambulatory Blood Pressure Monitor and Mobile App

Condition: Heart Disease / High Blood Pressure
Investigator: Daichi Shimbo, MD
Status: Currently Recruiting
The measurement of blood pressure is used to determine if a person has abnormal blood pressure, usually high blood pressure (also known as hypertension) and whether their blood pressure is controlled while taking medications that lower blood pressure. For many people, current cuff-based blood pressure devices are uncomfortable, non-portable, and susceptible…
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HIV Vaccine Study: HVTN 312

Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, MD
Status: Currently Recruiting
The HIV Vaccine Trials Network, Division of AIDS, and Columbia University Irving Medical Center are conducting a trial to learn about the safety and effectiveness of two new experimental HIV vaccines. This is a first-in-human phase 1 clinical trial where we will be testing 2 study vaccines, CH505M5 N197D mRNA-gp160 and CH505 TF mRNA-gp160. The goal is to…
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Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism (HI-PEITHO)

Condition: Heart Disease
Investigator: Sanjum Sethi, MD, MPH
Status: Currently Recruiting
The purpose of this study is to determine whether treatment with anticoagulation medications incombination with the EkoSonicTM Endovascular device with a dose of a clot-dissolving drug(thrombolytic) can reduce the risk of death and other serious problems when compared to anticoagulation medication alone. Other measurements will be taken to observe your…
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The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves). (MITRAL-II)

Condition: Valve Disease / Mitral Valve Disease
Investigator: Isaac George, MD
Status: Currently Recruiting
This is a prospective multicenter study whose purpose is to establish the safety and effectiveness of the Edwards SAPIEN 3 and SAPIEN 3 Ultra valves with Commander delivery system in patients with severe symptomatic calcific mitral valve disease with severe mitral annular calcification (which is a progressive loss of function of the mitral valve due to…
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Brain Mechanisms of Perceiving Faces

Condition: Healthy Volunteers
Investigator: Jon Freeman, PhD
Status: Currently Recruiting
The Social Cognitive & Neural Sciences Lab at Columbia University's Department of Psychology is conducting a brain imaging study, which will take place over the next 1-3 months. You will be compensated for your time and receive a free video of your brain! We are flexible in scheduling convenient times for you to come in. The study will involve a 2-…
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Immune Responses in Parkinson's and Alzheimer's Disease (Healthy Volunteers)

Condition: Healthy Volunteers
Investigator: Julian Agin-Liebes, MD
Status: Currently Recruiting
We are looking for participants for a study on the role of immune response in Parkinson's disease (PD) and Alzheimer's disease (AD). We are inviting people WITH PD, WITH AD, WITH amnestic Mild Cognitive Impairment, or WITHOUT PD or AD to come and participate. We will be doing several questionnaires, a motor exam, and a short cognitive assessment,…
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Human Memory and Decision Making - Healthy Volunteers

Condition: Healthy Volunteers
Investigator: Kiyohito Iigaya, PhD
Status: Currently Recruiting
Our lab is conducting a series of research studies investigating people's memory and decision-making. As a healthy study participant, you will be asked to complete a set of self-report questionnaires probing demographics and personality traits, followed by a number of computer-based tasks. Study participants earn between $15/hour for their time. The…
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Alzheimer's Disease Research Center (ADRC) - Healthy Volunteers

Condition: Healthy Volunteers
Investigator: Scott Small, MD
Status: Currently Recruiting
For over 30 years, The Columbia University Alzheimer's Disease Research Center (ADRC) has worked with thousands of participants who have helped provide important insights into how the brain ages and why Alzheimer's disease may develop. We are actively recruiting adults 65 years of age and older who share our commitment to be part of this…
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IDH Mega Study

Condition: Heart Disease / High Blood Pressure
Investigator: Daichi Shimbo, MD
Status: Currently Recruiting
The measurement of blood pressure is used to determine if a person has high blood pressure (also known as hypertension) and whether their blood pressure is controlled while taking medications that lower blood pressure. For many people, blood pressure levels are different when measured in a provider's office versus during normal daily activities outside…
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MyHeartMySelf

Condition: Heart Disease
Investigator: Billy Caceres, PhD, RN
Status: Currently Recruiting
Researchers at Columbia University School of Nursing are investigating how daily life experiences (such as stressful events) are associated with mental health, health behaviors, and blood pressure in adults. We are recruiting non-pregnant English-speaking adults between the ages of 18-64 who have no history of hypertension or cardiovascular disease.…
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Does Your Nose Remember? Understanding the Role of Smell in Memory Processes

Condition: Healthy Volunteers
Investigator: Jonathan Overdevest, MD, PhD
Status: Currently Recruiting
The Columbia Otolaryngology Department is interested in understanding how sense of smell relates to memory and neurocognition. Participation will involve answering a series of questionnaires, completing a formal evaluation of your smell with standardized measurements, and complete short smell and memory games. You can participate in this study if you are…
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Fair Start Study - How Environmental Exposures During Pregnancy Influence the Health and Development of Children

Condition: Healthy Volunteers
Investigator: Julie Herbstman, PhD, MSc
Status: Currently Recruiting
You are invited to participate in a research study to understand how environmental exposures during pregnancy influence the health and development of children. This study will begin at pregnancy and follow your child through age 11. A trained research worker will work with you and your child, administering questionnaires to you and developmental evaluations…
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Blood Donor Study for Adult Males of African, Asian, Hispanic, Middle Eastern, or Mediterranean Descent

Condition: Healthy Volunteers
Investigator: Richard Francis, MD, PhD
Status: Currently Recruiting
This is a Blood Donor Study being conducted at Columbia University Irving Medical Center New YorkPresbyterian Hospital. We are interested in recruiting males between the ages of 18-65 who are of African, Asian, Hispanic, Middle Eastern, or Mediterranean descent. The purpose of this research study is to determine whether genetic factors in your DNA affect…
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Alzheimer's Variant Imaging Study (ADVISe) (Healthy Volunteers)

Condition: Healthy Volunteers
Investigator: Patrick Lao, PhD
Status: Currently Recruiting
The purpose of this study is to determine how inflammation is related to changes in the brain that occur during the progression of Alzheimer's disease. If you are eligible for this study, we will ask you to complete 3-4 study visits over the course of about 5 months. Participation includes memory testing, a blood draw, MRI, PET scans, and a lumbar…
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PrEP for Women (HPTN 102/Purpose 3): An HIV Prevention Study for Women to Evaluate an Investigational Twice a Year PrEP Injection

Condition: Healthy Volunteers
Investigator: Ellen Morrison, MD, MPH
Status: Currently Recruiting
PrEP (Pre-Exposure Prophylaxis) is medication that is taken to prevent HIV if a person is exposed to HIV. Research is ongoing to identify PrEP medications that are both convenient and effective. This study is important because women in many areas of New York City have high rates of HIV coupled with low utilization of PrEP. The purpose of HPTN 102/Purpose 3…
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Effect of lowering insulin levels on blood sugar

Condition: Healthy Volunteers
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are conducting a research study on how insulin controls blood sugar in both healthy people and those at risk of type 2 diabetes. We are seeking adult volunteers, aged 18-65, who have body mass indices either in the lean range (18-25 kg/m2) or in the obesity range (30-45 kg/m2) but who do not have prediabetes or diabetes. Participants will undergo a…
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Lung MaPS - Healthy Volunteers

Condition: Healthy Volunteers
Investigator: Elizabeth Oelsner, MD, MPH
Status: Currently Recruiting
This study is called the COVID-19 Lung Microvascular and Parenchymal Sequelae (LUNG MaPS) Study. The purpose of the study is to learn about the effects of COVID-19 infections on the lungs and heart, and to improve our understanding of why some COVID-19 patients experience ongoing symptoms, or what is often called "long COVID." Hundreds of…
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HIV Vaccine: HVTN 144 - Healthy Volunteers

Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, MD
Status: Currently Recruiting
The HIV Vaccine Trials Network (HVTN) and Columbia University Irving Medical Center (CUIMC) are conducting a study to learn about the safety and effectiveness of an experimental HIV vaccine. The study vaccine is a protein vaccine called N332-GT5 gp140. It includes a manmade protein that looks like a protein found on the outside of HIV. The study vaccine is…
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Detect Blood Pressure (BP) Study

Condition: Healthy Volunteers
Investigator: Marwah Abdalla, MD
Status: Currently Recruiting
The Center for Behavioral Cardiovascular Health (CBCH) is conducting a research study to examine the impacts on blood pressure when it is measured with and without someone in the room with you. Two-part screening to determine eligibility for this study involves a) answering questionnaires and b) measuring your arm circumference. Participation in the…
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Studying Neural Mechanisms of Behavior and Cognition via Computer-Based Tasks (Ages 18-60)

Condition: Healthy Volunteers
Investigator: Kiyohito Iigaya, PhD
Status: Currently Recruiting
Our lab is conducting a magnetic resonance imaging (fMRI) study to investigate people's memory and decision-making. We are looking for people between the ages of 18 and 60 to be healthy study participants. In this study you will be asked to complete a set of self-report questionnaires probing demographics and personality traits, followed by a number of…
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Lifestyle Patterns Study

Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Currently Recruiting
The overall goal of this project is to assess the role of rest-activity patterns on glucose control, body composition, and well-being. We are currently looking for non-smoking men and women, age 25 years or older and with pre-diabetes (HbA1c 5.7-6.4%) to participate in this study. You must regularly sleep at least 6 hours/night and have variable sleep…
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Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial in Patients with Mitral Regurgitation

Condition: Valve Disease / Mitral Valve Disease
Investigator: Susheel Kodali, MD
Status: Currently Recruiting
The study is designed to compare the safety and effectiveness of the PASCAL System to the MitraClip System for reduction of degenerative mitral regurgitation.
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Memory Processes in the Brain

Condition: Healthy Volunteers
Investigator: Lila Davachi, PhD
Status: Currently Recruiting
The Davachi Lab is currently running research studies to investigate information processing. These behavioral studies may involve looking at negative, neutral, and positive images on a computer screen (such as objects, faces, or scenes) and/or listening to negative, neutral, and positive auditory sounds (such as tones with varied pitches or human-produced…
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Temporary Insulin Resistance

Condition: Healthy Volunteers
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are recruiting volunteers, aged 18-70, for a research study on the buildup of excessive liver fat ("fatty liver disease") in people with or at risk for type 2 diabetes because their bodies are resistant to the actions of the blood sugar-lowering hormone, insulin. To do this, we seek to temporarily induce or accentuate insulin resistance in 14…
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Biobank of Blood Samples from Overweight or Obese Patients

Condition: Healthy Volunteers
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are seeking adult volunteers with body mass index in the obesity range (30-45 kg/m2) to come in for a single study visit where they answer some health questions and have a small volume of blood drawn (25 cc/1.7 tbsp). We will measure levels of the blood sugar-lowering hormone insulin as well as glucose (sugar), certain fats, and other molecules related…
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Effects of Growth Hormone and Liraglutide

Condition: Healthy Volunteers
Investigator: Pamela Freda, MD
Status: Currently Recruiting
Growth hormone and insulin-like growth-factor 1 (IGF-1) are two hormones that are very important to human growth and metabolism. In disorders of GH and IGF-1 excess and deficiency, significant growth and metabolic abnormalities can develop. This study investigates the effects of GH on the appetite-stimulating hormone AgRP (agouti-related peptide) and the…
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RiSE Study - Race-Based Stress Reduction and Resilience Program for African-American Women

Condition: Heart Disease / High Blood Pressure
Investigator: Jacquelyn Taylor, PhD, MSN, BSN
Status: Currently Recruiting
Race-Based Stress Reduction and Resilience Program for African-American Women. Join this important research study to examine the effectiveness of an eight-week stress reduction program for older African-American women. To learn more contact 347-978-2871 or son_RiSEstudy@cumc.columbia.edu. Study Requirements: African-American female between 50-75 years old,…
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Study of OPTIMIZER System in Patients with Heart Failure with Reduced Ejection Fraction (HFrEF)

Condition: Heart Disease / Heart Failure
Investigator: Hirad Yarmohammadi, MD, MPH
Status: Currently Recruiting
You may want to join this study because your heart condition may respond to a device-based therapy called cardiac modulation therapy called the OPTIMIZER System. The OPTIMIZER INTEGRA CCM-D System, also known as a Cardiac Contractility Modulation Defibrillator, is an investigational device system that combines CCM therapy and ICD therapy into one device.…
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Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature (ELEGANCE)

Condition: Heart Disease / Peripheral Arterial Disease
Investigator: Sahil Parikh, MD
Status: Currently Recruiting
This study aims to collect information about the symptoms and treatments of patients who have severely clogged arteries and are treated with commercially available Boston Scientific Corporation drug-eluting devices marketed for the treatment of lesions located in the peripheral vasculature. Participation in the study is expected to last for up to two (2)…
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Reasons for Choosing Stent or Bypass Surgery Among Underrepresented Groups

Condition: Heart Disease
Investigator: Ruth Masterson Creber, PhD
Status: Currently Recruiting
We are seeking insights from a diverse group of community members and leaders, especially African-American and Latino individuals. The primary aim is to understand the factors influencing the decision between the PCI and CABG procedures. Participation will involve a 20-minute survey. Some survey participants might also be invited for a focus group or an…
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Study of Memory Loss in Patients with Alzheimer's Disease or Mild Cognitive Impairment (MCI) - Healthy Volunteers

Condition: Healthy Volunteers
Investigator: Catherine Clelland, PhD
Status: Currently Recruiting
This research study aims to obtain a greater understanding of the causes of cognitive decline in Alzheimer's disease. We are currently enrolling male and female participants (ages 55 years and older) with Alzheimer's disease, mild cognitive impairment, or healthy controls. Enrolled participants with undergo a small blood draw (about 8 teaspoons)…
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COVID CT Registry (Healthy Volunteers)

Condition: Heart Disease
Investigator: Andrew Einstein, MD
Status: Currently Recruiting
We are seeking patients that have had a pre-COVID heart CT scan (Coronary Computed Tomography Angiography) that was performed at Columbia University Irving Medical Center/NewYork-Presbyterian Hospital before March of 2020. For this study, half of patients will be required to have had COVID-19 symptoms (e.g., fever, cough, shortness of breath) and would have…
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MitraClip REPAIR MR Study in Patients with Primary Mitral Regurgitation

Condition: Valve Disease / Mitral Valve Disease
Investigator: Susheel Kodali, MD
Status: Currently Recruiting
This is a randomized controlled trial (RCT) that will compare the clinical outcome of MitraClip device versus surgical repair in patients with severe primary MR who are at moderate surgical risk and whose mitral valve has been determined to be suitable for correction by MV repair surgery by the cardiac surgeon on the local site heart team. In this trial,…
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Congenital Anomalies Research Exploration - CARE study

Condition: Healthy Volunteers
Investigator: Yufeng Shen, PhD
Status: Currently Recruiting
Study examining the genetic causes of birth defects.
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Lowering Insulin Levels in Fatty Liver Disease

Condition: Healthy Volunteers
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, aged 18-70, who are overweight or obese with a body mass index of 27-50, and have been diagnosed with, or are at risk for, prediabetes.…
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Traumatic Brain Injury Effect on Blood Brain Barrier (Healthy Volunteers)

Condition: Healthy Volunteers
Investigator: Dritan Agalliu, PhD
Status: Currently Recruiting
The aim of this study is to understand the mechanisms of secondary effects of traumatic brain injury on the blood-brain barrier and to understand the biochemical differences in the blood of people with Alzheimer's disease and the volunteer group. We will compare biochemical blood differences between a healthy group and traumatic brain injury patients…
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REBIRTH - Study of Bromocriptine in Women with Peripartum Cardiomyopathy (PPCM)

Condition: Heart Disease / Cardiomyopathy
Investigator: Jennifer Haythe, MD
Status: Currently Recruiting
We are doing this study to test the use of a drug called bromocriptine for women with a condition called Peripartum cardiomyopathy (PPCM). The study will look at how the heart muscle improves in women taking bromocriptine compared to a group of women given a placebo or inactive pill.
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The Yo-Yo Sleep Study

Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Currently Recruiting
We are currently looking for healthy, nonsmokers, ages 18-49yrs who are satisfied with their sleep to participate in a sleep study. Participants should typically sleep 7-9 hours/night without external sleep aids. Participants must be willing to change their sleep schedule for approximately 4 weeks. Compensation of up to $1000 will be provided for completing…
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Columbia University Biobank

Condition: Healthy Volunteers
Investigator: Muredach Reilly, MD
Status: Currently Recruiting
As an academic medical center, we are always working to improve patient and population health. One way that research is supported here is through the Columbia University Biobank (CUB). A biobank is a collection of biological samples and health data that is collected during a patient's medical care. The goal of a biobank is to provide materials for…
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The PROTECT IV Trial

Condition: Heart Disease / Coronary Artery Disease
Investigator: Michael Collins, MD
Status: Currently Recruiting
This is a Prospective, multicenter, randomized, parallel-controlled, open-label two-arm trial with an adaptive design that will randomize about 1252 subjects at approximately 120 US and international centers. The study is looking to see if a device called the Impella device will improve the way the heart works as well as if health is improved as compared to…
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Learning to Perform Reaching and Lifting Movements Using a Robotic Interface

Condition: Healthy Volunteers
Investigator: Daniel Wolpert, PhD
Status: Currently Recruiting
The Sensorimotor Learning Lab at Columbia University is conducting behavioral studies of how our brains control movement. We are looking for volunteers to take part in experiments involving moving in virtual reality, interacting with robotic interfaces and other movement tasks. All the experiments are noninvasive and have been approved by the Columbia IRB.…
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Pregnancy and RNA

Condition: Healthy Volunteers
Investigator: S. Zev Williams, MD, PhD
Status: Currently Recruiting
Researchers at Columbia are looking at the changes that happen in the placenta when people become pregnant. Participation in this study involves a blood draw at three time points. Participants will be paid $50 at each time point. Participants who complete all three time points will receive bonus compensation.
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CLASP II TR: Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial in Patients with Tricuspid Regurgitation

Condition: Valve Disease / Tricuspid Valve Disease
Investigator: Susheel Kodali, MD
Status: Currently Recruiting
The goal of this early feasibility study is to gain initial insight into the basic safety and performance of transluminal (through the blood vessels) implantation of the PASCAL System's implant (composed of man-made materials). We are trying to evaluate the safety and performance of the PASCAL System with Optimal Medical Therapy (OMT) (also known as…
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The BREAK II Study: Breaking up Prolonged Inactivity to Improve Cardiometabolic Health

Condition: Healthy Volunteers
Investigator: Keith Diaz, PhD
Status: Currently Recruiting
U.S. Adults spend on average 11 to 12 hours a day sitting. Daily sedentary behavior is strongly associated with the risk of heart disease. The purpose of the BREAK II research study is to answer two questions: (1) How frequently should periods of prolonged sedentary time be interrupted? and (2) What is the appropriate duration or length of time of these…
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Development of Biomarkers for Radiation Exposure

Condition: Healthy Volunteers
Investigator: David Brenner, PhD
Status: Currently Recruiting
The purpose of this study is to use blood from healthy people to develop a test to see if people have been exposed to radiation. Between 2 and 3 tablespoons of blood will be drawn from your arm. The blood will be tested with radiation in our laboratory at the Center for Radiological Research at the Columbia University Irving Medical Center. We will measure…
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TTVR Early Feasibility Study in Patients with Symptomatic Severe Tricuspid Regurgitation - Medtronic

Condition: Valve Disease / Tricuspid Valve Disease
Investigator: Susheel Kodali, MD
Status: Currently Recruiting
This is a research study for patients who have Tricuspid Regurgitation (TR), a condition that occurs when the three leaflets of the heart's tricuspid valve do not close properly causing blood to leak backward with each heartbeat. Since some of the blood leaks backward, the heart has to pump more blood with each beat to push the same amount of blood…
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The PhenoGenetic Project

Condition: Healthy Volunteers
Investigator: Philip De Jager, PhD
Status: Currently Recruiting
The purpose of this study is to establish a collection of biological fluids and associated data from healthy individuals to determine how genetic and environmental variation affects the immune system. Study visits consist of taking vitals and collecting biological fluids, such as blood. You will be compensated for participating in this study.
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The Molecular Basis of Cardiopulmonary Disorders (Healthy Participants and Children Over 7 Welcome)

Condition: Healthy Volunteers
Investigator: Christine Kim Garcia, MD
Status: Currently Recruiting
The purpose of this study is to identify genetic causes of lung diseases and to develop a research repository so that we can better understand, prevent and treat these conditions. You have been asked to join this study as a healthy control. Even though you do not have lung disease, your sample is valuable to us. For example, you may be related to someone…
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Changes in Brain Biomarkers After Bariatric Surgery or Low-Calorie Diet (ages 18-65)

Condition: Healthy Volunteers
Investigator: Sharon Wardlaw, MD
Status: Currently Recruiting
The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms. Cerebrospinal fluid neuropeptides, hormones, and protein levels will be measured in subjects before and after bariatric surgery as compared with subjects before and after diet-induced weight loss. Participants in the…
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ACURATE IDE: Study of Acurate Valve for Transcatheter Aortic Valve Replacement

Condition: Valve Disease / Aortic Valve Disease
Investigator: Tamim Nazif, MD
Status: Currently Recruiting
This prospective, multicenter trial is looking at the investigative device called the ACURATE Transcatheter Aortic Valve System for TAVR to see if it is safe and effective in treating patients with severe symptomatic native aortic stenosis. The ACURATE Transcatheter Aortic Valve System for TAVR is designed for iliofemoral access and delivery of a self-…
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Medtronic Product Surveillance Registry Post Approval Network (PAN)

Condition: Heart Disease
Investigator: Frederick Ehlert, MD
Status: Currently Recruiting
The purpose of this registry is to collect information over time about how Medtronic products are working and/or the outcome of the treatment. The registry will be used to support post-market surveillance/monitoring activities and post-approval studies (e.g., to collect safety and performance information). In addition, it will be used to obtain clinical…
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"Does This Item Belong?" - Study in Adult Healthy Volunteers of How We Use and Update Knowledge

Condition: Healthy Volunteers
Investigator: Lila Davachi, PhD
Status: Currently Recruiting
The Davachi Lab is currently running research studies to investigate information processing. These behavioral studies may involve looking at neutral images on a computer screen (such as objects, faces, or scenes) and/or listening to neutral auditory sounds (such as natural ambiance or artificial tones), and making judgments about them. In this study,…
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Healthy Brain Donation Project - Brain Bank

Condition: Healthy Volunteers
Investigator: Philip De Jager, PhD
Status: Currently Recruiting
The Snapshot study aims to understand brain and spinal cord aging in healthy individuals and individuals with multiple sclerosis (MS). We aim to identify new tools that will help us to achieve successful brain aging in the general population and in people with an underlying autoimmune disease. A critical aspect of this study is that we are looking for…
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HIV Prevention Study

Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, MD
Status: Currently Recruiting
We are looking for individuals 18 to 60 years old who are interested in learning more about HIV prevention and biomedical research studies. We will ask you to complete a brief questionnaire to find out if we can schedule you for a one-on-one, 1.5-hour education visit to learn about the research we do. The education visit will help you decide if you want to…
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