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Displaying 1 - 92 of 92
Condition: Psychiatric Disorders / Eating Disorders
Investigator: Timothy Walsh, MD
Status: Currently Recruiting
Anorexia Nervosa is a serious illness and relapse rates are high. We have shown that behavioral routines get stuck/entrenched. Our newest research, Relapse Prevention and Changing Habits (REACH+) for Anorexia Nervosa, aims to help patients minimize unhelpful routines and develop more healthful recovery-oriented behavior. Participants will complete initial…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Kiyohito Iigaya, PhD
Status: Currently Recruiting
Our lab is conducting brain imaging research studies investigating people's behavior. We are looking for people between the ages of 18 and 65 to be study participants. As a schizophrenia study participant, you will be asked to complete a set of self-report questionnaires probing personality traits. You will also complete a number of computer-based…
Condition: Transplant / Liver Transplant
Investigator: Marcus Pereira, MD, MPH
Status: Currently Recruiting
This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with HIV compared to donors without HIV. If you have any questions regarding this study, please contact the Transplant Clinical Research Center (TCRC).
Condition: Psychiatric Disorders
Investigator: Rachel Marsh, PhD
Status: Currently Recruiting
This research study will examine how an iPad-based cognitive training game combined with cognitive behavioral therapy (CBT) helps children with excessive worries and related repetitive behaviors (obsessive compulsive disorder). After completing the training, all children will be offered CBT, delivered by experts at no cost. This study will take place at…
Condition: Psychiatric Disorders
Investigator: Randy Auerbach, PhD
Status: Currently Recruiting
The study uses brain imaging and cortisol to understand risk and protective factors for mental health among adolescents on social media. We are currently recruiting adolescents ages 14-17 who recently visited the emergency room for suicide-related concerns. To participate in our study, we would ask your child to: (a) complete a mental health interview (over…
Condition: Psychiatric Disorders / Depression
Investigator: Sarah Herzog, PhD
Status: Currently Recruiting
We are conducting a study on depression and suicide risk, and participants can earn up to $300 for taking part. Suicide rates in the U.S. are rising, and new treatments are urgently needed. This study focuses on the brain chemical glutamate, which may play an important role in mood and mental health. We will compare glutamate levels at rest and during…
Condition: Transplant / Liver Transplant
Investigator: Sloane Heller, Md
Status: Currently Recruiting
The purpose of this study is to understand how liver disease affects thinking and memory, both before and after transplant. Participants will take a cognitive test, which will be a series of tasks and questions similar to a video game, at home on their own computers, tablets, or phones. This will take approximately 45 minutes, and participants will do this…
Condition: Transplant / Liver Transplant
Investigator: Yael Nobel, MD, MS
Status: Currently Recruiting
A complication that can occur after liver transplant (LT) is rejection, in which the patient's immune system damages the transplanted liver. This complication can be prevented with immunosuppressant medications, which are routinely used after LT. The main purpose of this study is to determine if bacteria in the intestine (gut microbiome) may affect the…
Condition: Transplant / Liver Transplant
Investigator: Elizabeth Verna, MD
Status: Currently Recruiting
The purpose of this observational research study is to identify things that contribute to outcomes in patients with alcohol-associated liver disease who are being considered for liver transplant and who have less than 6 months of sobriety. We will look at many things including images of the liver and heart, blood tests, urine tests, stool tests and liver…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Guillermo Horga, MD, PhD
Status: Currently Recruiting
In this study, we are trying to learn more about the symptoms of psychosis, specifically to learn how alterations in the brain may produce certain experiences (including voice hearing or auditory hallucinations) that are common in people with psychosis or schizophrenia. The study involves clinical interviews, computer tests, and magnetic resonance imaging (…
Condition: Transplant / Liver Transplant
Investigator: Elizabeth Verna, MD
Status: Currently Recruiting
The main purpose of this study is to deeply characterize cognitive function in liver transplant recipients, differentiate among different causes of cognitive impairment, and identify contributors to cognitive impairment. Participants will receive a comprehensive neurological exam, cognitive assessment, neuropsychological testing, MRI of the brain, and blood…
Condition: Transplant / Liver Transplant
Investigator: Elizabeth Verna, MD
Status: Currently Recruiting
The purpose of this study is to evaluate the safety of siplizumab when used as induction immunosuppression in patients with primary sclerosing cholangitis or autoimmune hepatitis undergoing liver transplantation. Induction immunosuppression drugs are very potent anti-rejection drugs that are given immediately after transplantation to prevent rejection.…
Condition: Transplant / Liver Transplant
Investigator: Elizabeth Verna, MD
Status: Currently Recruiting
The purpose of this study is to learn more about the effects of functional status (also known as "frailty") using a physical test in patients with liver disease on their health outcomes. We are enrolling patients prior to liver transplantation, and will continue to assess their functional status post transplant. If you have any questions regarding…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Rachel Marsh, PhD
Status: Currently Recruiting
This research study will examine how an iPad-based cognitive training game combined with cognitive behavioral therapy (CBT) helps children with excessive worries and related repetitive behaviors (obsessive compulsive disorder). After completing the training, all children will be offered CBT, delivered by experts at no cost. This study will take place at…
Condition: Transplant / Liver Transplant
Investigator: Marcus Pereira, MD, MPH
Status: Currently Recruiting
The primary objective is to evaluate long-term outcomes in transplant recipients with HIV who receive livers from donors with HIV compared to donors without HIV. If you have any questions regarding this study, please contact the Transplant Clinical Research Center (TCRC).
Condition: Psychiatric Disorders / Depression
Investigator: Randy Auerbach, PhD
Status: Currently Recruiting
We are recruiting depressed adolescents ages 13-18 years. As a participant in our study, we will: (1) interview your child about current and past thoughts, feelings, and behaviors, (2) teach your child mindfulness strategies, (3) collect brain activity data with MRI (non-invasive) while your child practices mindfulness, and (4) send short surveys to your…
Condition: Transplant / Liver Transplant
Investigator: Tomoaki Kato, MD
Status: Currently Recruiting
The purpose of this sponsor initiated multi center registry is to collect additional data on the performance of the FDA Approved OCS Liver System and post transplant clinical outcomes for patients who are transplanted with an OCS Liver perfused donor liver in the real world setting. If you have any questions regarding this study, please contact the…
Condition: Psychiatric Disorders / Depression
Investigator: Marcella Walker, MD
Status: Currently Recruiting
Depression and some antidepressants may be associated with an increased risk of breaking a bone. It is not clear why this could be the case. It is possible that depression and/or certain medications used for the treatment of depression cause bone loss, increase the risk of falls, are associated with lower physical activity, or effects on muscle function.…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Reilly Kayser, MD
Status: Closed
The Center for OCD Research at Columbia University Irving Medical Center is seeking individuals with obsessive-compulsive disorder (OCD) to participate in a research study, at no cost to you. This study is investigating the medicinal effects of nabilone for OCD symptoms. Nabilone is a synthetic form of tetrahydrocannabinol (THC), which is one of the active…
Condition: Transplant / Liver Transplant
Investigator: Steven Lobritto, MD
Status: Closed
In this study, we will collect information from the medical record of pediatric liver transplant recipients who received live vaccines as part of their routine post-transplant care. This data will be combined with data from other centers across the United States and Canada to help give us a better understanding of the safety and efficacy of live vaccines in…
Condition: Psychiatric Disorders
Investigator: Kiyohito Iigaya, PhD
Status: Closed
Our lab is conducting research studies investigating people's behavior. We are looking for people between the ages of 18 and 65 who have been diagnosed with Schizophrenia/Depression to be study participants. As a study participant, you will be asked to complete a set of self-report questionnaires probing personality traits and computer-based tasks.…
Condition: Psychiatric Disorders / Anxiety
Investigator: Kate Fitzgerald, MD
Status: Closed
This research study seeks to better understand the biological and behavioral aspects of specific phobia and evaluate how the "Self-Distancing" technique might help youth confront their fears. The study will be conducted at Columbia University in Manhattan. Participation involves completing questionnaires and attending a single visit for a…
Condition: Psychiatric Disorders / Depression
Investigator: Joshua Berman, MD, PhD
Status: Closed
Are you suffering from chronic depression? We are seeking participants for a depression treatment research study at Columbia University using Transcranial Magnetic Stimulation (TMS). This study develops a more accurate TMS to treat chronic depression. Participation includes clinical assessments and magnetic resonance imaging (MRI). You will receive 27…
Condition: Transplant / Liver Transplant
Investigator: Steven Lobritto, MD
Status: Closed
The purpose of the study is to collect scientific data on pediatric liver transplantation to learn more about how children do after liver transplant. Collecting these data is expected to help researchers learn more about liver transplant in children. This information may improve medical care of your child and other children who need and who have received…
Condition: Obstetrics & Gynecology / Reproductive & Hormonal Disorders
Investigator: S. Zev Williams, MD, PhD
Status: Closed
Researchers at Columbia are looking at new treatments to help delay the start of menopause. This is a randomized trial where some women will receive medication and some will receive a placebo. The study will last approximately 12 weeks, followed by monthly follow-ups for 6 months. Participants will be compensated $1300 for compensation.
Condition: Transplant / Liver Transplant
Investigator: Marcus Pereira, MD, MPH
Status: Closed
The primary objective of this study is to determine if an HIV-infected donor liver (HIVD+) transplant is safe with regards to major transplant-related and HIV-related complications. This study will evaluate if receiving a liver transplant from an HIV-infected deceased liver donor is safe with regards to survival and major transplant-related and HIV-related…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Amy Rapp, PhD
Status: Closed
The goal of the project is to identify differences in learning in obsessive-compulsive disorder (OCD) by measuring the activity of the brain while participants complete computer tasks. Eligible participants will be asked questions about their medical and psychiatric history and perform tasks on a computer while an electroencephalogram (EEG) is recorded.…
Condition: Psychiatric Disorders / Depression
Investigator: Randy Auerbach, PhD
Status: Closed
This study uses smartphone technology to better understand changes in adolescent moods over time. As a participant in our study, we would: (a) interview your child about current and past thoughts, feelings, and behaviors and (b) collect data from your child's smartphone for 6 months through an app called the Effortless Assessment of Risk States (EARS;…
Condition: Psychiatric Disorders
Investigator: Doron Amsalem, MD
Status: Closed
We are conducting a research study to explore discrimination around depression and barriers to care in youth ages 14-18. We will use what we learn to create videos to reduce such discrimination. Parental permission is required for this study. Adolescents (ages 14-18) will participate in an individual interview that will be approximately 45 minutes long. We…
Condition: Psychiatric Disorders / Depression
Investigator: Doron Amsalem, MD
Status: Closed
We are conducting research to explore self-stigma around depression, racial/ethnic and cultural experiences, and barriers to care (e.g., embarrassment, limited access, low expectations/motivation). Self-stigma refers to negative beliefs a person has about themself due to their mental illness. We are looking for Latinx or Black young adults ages 18-25 who…
Condition: Psychiatric Disorders / Depression
Investigator: Doron Amsalem, MD
Status: Closed
We are conducting research to explore the level of self-stigma around depression, racial/ethnic and cultural experiences, and barriers to care (e.g., embarrassment, limited access, low expectations/motivation). Self-stigma refers to negative beliefs a person has about themself due to their mental illness. We are looking for Latinx or Black young adults ages…
Condition: Psychiatric Disorders / Depression
Investigator: Doron Amsalem, MD
Status: Closed
We are conducting a research study to explore discrimination around depression and barriers to care in youth ages 14-18. We will use what we learn to create videos to reduce such discrimination. Parental permission is required for this study. Adolescents (ages 14-18) will participate in an individual interview that will be approximately 45 minutes long. We…
Condition: Psychiatric Disorders / Eating Disorders
Investigator: Kelsey Hagan, PhD
Status: Closed
People with bulimia nervosa engage in risky behaviors more often than people without this disorder. We are researching the neurobiological underpinnings of risky decision-making in bulimia nervosa. As a participant in this study, you would: (1) complete a series of questionnaires and interviews, (2) complete an MRI scan (no radiation), and (3) complete…
Condition: Psychiatric Disorders / Eating Disorders
Investigator: Kelsey Hagan, PhD
Status: Closed
People with bulimia nervosa engage in risky behaviors more often than people without this disorder. We are researching the neurobiological underpinnings of risky decision-making in bulimia nervosa. As a participant in this study, your teen would: (1) complete a series of questionnaires and interviews, (2) complete an MRI scan (no radiation), and (3)…
Condition: Psychiatric Disorders / Depression
Investigator: Elizabeth Sublette, MD, PhD
Status: Closed
This research study uses non-invasive brain imaging called functional near-infrared spectroscopy (fNIRS). For fNIRS, a small infrared bulb shines light through the skull, and a special light detector is able to measure oxygen use in the brain. Our goal is to understand oxygen use by brain mitochondria cells in major depression and how this is affected by…
Condition: Psychiatric Disorders / Bipolar Disorder
Investigator: Martin Lan, MD
Status: Closed
This is a research study to understand what causes bipolar disorder and how medications treat bipolar depression. Particularly, we are looking at the importance of inflammation in the process. If you participate, you will receive an experimental medication for your depression named ethyl eicosapentaenoic acid (ethyl EPA), an omega 3 fatty acid. You will…
Condition: Psychiatric Disorders / Borderline Personality Disorder
Investigator: Jeffrey Miller, MD
Status: Closed
The goal of this study is to examine how effective and well-tolerated a possible new treatment for individuals who injure themselves frequently will be. All research procedures can be done from home no in-person visits are required. We are studying a minimal-risk form of electrical brain stimulation called transcranial direct current stimulation, or tDCS.…
Condition: Psychiatric Disorders / Bipolar Disorder
Investigator: Jeffrey Miller, MD
Status: Closed
The goal of this study is to examine how effective and well-tolerated a possible new treatment for individuals who injure themselves frequently will be. All research procedures can be done from home no in-person visits are required. We are studying a minimal-risk form of electrical brain stimulation called transcranial direct current stimulation, or tDCS.…
Condition: Psychiatric Disorders / Depression
Investigator: Jeffrey Miller, MD
Status: Closed
The goal of this study is to examine how effective and well-tolerated a possible new treatment for individuals who injure themselves frequently will be. All research procedures can be done from home no in-person visits are required. We are studying a minimal-risk form of electrical brain stimulation called transcranial direct current stimulation, or tDCS.…
Condition: Psychiatric Disorders / Anxiety
Investigator: Amir Levine, MD
Status: Closed
Sertraline (also known as Zoloft) is an FDA approved medication that is used to treat anxiety in children and adolescents. We aim to better understand how children and adolescents with anxiety respond to sertraline and whether we can predict medication response. If your child is eligible, he or she can participate in a research study and will receive both a…
Condition: Psychiatric Disorders / Depression
Investigator: David Hellerstein, MD
Status: Closed
We are currently enrolling individuals with Major Depressive Disorder (MDD) to participate in this research study. This is a one-year open-label study to evaluate the long-term safety and tolerability of an investigational drug called REL-1017 (esmethadone) when taken alone (monotherapy) or when taken with other antidepressants (adjunctive therapy). Study…
Condition: Psychiatric Disorders
Investigator: Lawrence Kegeles, MD
Status: Closed
Are you between the ages of 18-35? Do you have schizophrenia or schizoaffective disorder? Researchers at the New York State Psychiatric Institute are currently seeking participants who are interested in a brief trial of anti-psychotic medication. This study will include: - magnetic resonance imaging (MRI) - a physical exam - clinical and neurocognitive…
Condition: Psychiatric Disorders / PTSD
Investigator: Franklin Schneier, MD
Status: Closed
We are currently enrolling individuals with post-traumatic stress disorder (PTSD) to participate in this research study. The purpose of this research study is to evaluate the effectiveness of an investigational medication, brexpiprazole, for PTSD. Eligible participants will be randomly assigned to receive either brexpiprazole, sertraline (also known as…
Condition: Psychiatric Disorders / Depression
Investigator: Jeffrey Miller, MD
Status: Closed
Do you suffer from depression? Have standard treatments not been helpful? Researchers at Columbia University Irving Medical Center are conducting a study of an experimental antidepressant called ketamine, which can provide rapid relief of depressive symptoms in some patients. The study involves an inpatient stay, during which participants undergo brain…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Gaurav Patel, MD, PhD
Status: Closed
Our lab is conducting a series of research studies that investigate how specific brain regions are related to functioning in work, school, and in other social situations. As a study participant, you will be asked to complete clinical and neuropsychological assessments, an eye-tracking task, and a non-invasive MRI scan. Study participants earn between $15-50…
Condition: Transplant / Liver Transplant
Investigator: Elizabeth Verna, MD
Status: Closed
The purpose of this study is to see if the study drug Harvoni given for 4 weeks immediately after liver transplantation is safe and able to clear the Hepatitis C virus (HCV) from the body. This study will test a drug named Harvoni for the treatment of chronic genotype 1 or 4 Hepatitis C Virus (HCV) in peri-operative liver transplant patients. Harvoni (LDV/…
Condition: Psychiatric Disorders / Bipolar Disorder
Investigator: Martin Lan, MD
Status: Closed
We are trying to understand what causes bipolar disorder and how medications treat bipolar depression. Particularly, we are looking at the importance of dopamine signaling in the process. If you participate, you will have two different brain scans (MRI and PET scan). You will also have treatment for your depression with an FDA approved medication,…
Condition: Psychiatric Disorders / Depression
Investigator: David Hellerstein, MD
Status: Closed
This is a pre-marketing (Phase 2A) multi-site study of an investigational drug, ganaxolone, as a potential treatment for non-psychotic post-partum depression. Eligible subjects who agree by signing informed consent will spend four days on the 5-South Research Unit (5-S) of the New York State Psychiatric Institute. For 6 hours they will have an tube in a…
Condition: Psychiatric Disorders / Depression
Investigator: Patrick Brown, PhD
Status: Closed
The goal of this open-administration treatment study of escitalopram (or duloxetine) is to evaluate the effect of antidepressant medication on treating the syndrome of frailty in older adults with depressive symptoms. Patients with significant depressive symptoms and 1 or more symptoms of the frailty syndrome (exhaustion, decreased energy, weight loss,…
Condition: Transplant / Liver Transplant
Investigator: Tomoaki Kato, MD
Status: Closed
The purpose of this study is to investigate a new therapeutic regimen with or without steroids in the pediatric population. The aim is to find out whether everolimus is safe and has beneficial effects in children who receive a liver transplant. All children will receive a study drug called everolimus twice a day plus a reduced dose of cyclosporine or…
Condition: Psychiatric Disorders
Investigator: Yuval Neria, PhD
Status: Closed
Columbia University Medical Center is presently recruiting individuals who have experienced trauma to participate in an fMRI research study. For your participation, you will receive up to $270 and an opportunity to advance research in the area of trauma and PTSD. This study involves two visits.
Condition: Psychiatric Disorders / Anxiety
Investigator: Franklin Schneier, MD
Status: Closed
We are currently enrolling individuals with social anxiety disorder to participate in this study. The purpose of this study is to assess whether a brief computer-based research treatment helps improve social anxiety symptoms. For eligible participants, this study will involve a brief, novel research treatment for social anxiety, delivered in 8 or 12…
A study for kidney transplant subjects using study drug eculizumab to prevent delayed graft function
Condition: Transplant / Liver Transplant
Investigator: Lloyd Ratner, MD, MPH, FACS
Status: Closed
The purpose of this study is to determine if eculizumab is safe and could be used to prevent Delayed Graft Function (DGF) following kidney transplantation. DGF is an early complication of kidney transplantation. This condition occurs when the transplanted kidney does not recover instantly after transplantation and can take days to weeks before recovering…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Reilly Kayser, MD
Status: Closed
The Center for OCD and Related Disorders at New York State Psychiatric Institute/Columbia University Medical Center is seeking individuals aged 18+ with obsessive-compulsive disorder (OCD) to participate in a survey regarding their experiences with marijuana/cannabis. We hope this study will lead to increased understanding of how these substances affect…
Condition: Psychiatric Disorders / Depression
Investigator: Ellie McGlinchey, PhD
Status: Closed
We are conducting research to compare different ways of improving sleep and mood in teens. Treatment involves Behavioral Sleep Therapy and Interpersonal Psychotherapy for Adolescents targeting: depression trouble falling and staying asleep not feeling rested on waking feeling sleepy during the day. Study Procedures: ~ A free, thorough diagnostic evaluation…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Jeffrey Lieberman, MD
Status: Closed
This study plans to learn more about an investigational new drug called lumateperone tosylate (ITI-007) and may help us find new types of treatment for schizophrenia and schizoaffective disorder.
Condition: Psychiatric Disorders / Anxiety
Investigator: Franklin Schneier, MD
Status: Closed
RESEARCH STUDY:Brief Intervention for Public Speaking Fears (IRB#7293).- Are you between the ages of 18 - 60?- Do you have bothersome fears of public speaking?- Are you interested in trying a novel intervention?This research study tests whether a brief intervention using a medication called propranolol is effective at reducing public speaking fears. This…
Condition: Psychiatric Disorders / Bipolar Disorder
Investigator: Joshua Kantrowitz, Md
Status: Closed
We will evaluate the D-cycloserine (DCS) and lurasidone with MRI measurement of brain responses to DCS. DCS is a drug that works on the same brain receptor as ketamine. DCS is not approved by the FDA for bipolar depression. Study participants will receive a dose of lurasidone or placebo in one MRI and a dose of DCS in another, followed by an optional follow…
Condition: Psychiatric Disorders / Depression
Investigator: Ian Kronish, MD
Status: Closed
This study will allow cancer survivors an opportunity to learn whether light therapy is helpful to them in addressing common concerns of cancer survivors such as fatigue, feeling low, and/or trouble sleeping by engaging in an N-of-1 or individualized trial.
Study for liver transplant recipients using drug (IgG) to prevent Hepatitis C virus (HCV) recurrence
Condition: Transplant / Liver Transplant
Investigator: Elizabeth Verna, MD
Status: Closed
The purpose of this study is to test the safety of different doses of HCIG when given to patients with HCV who receive a liver transplant. It will also provide information about whether HCIG can prevent HCV infection. Participation in the study is expected to last about 10 months. Participants will be randomly assigned to either receive HCIG or not. Your…
Condition: Psychiatric Disorders / Depression
Investigator: Yuval Neria, PhD
Status: Closed
Approximately half of the individuals with Post-traumatic Stress Disorder (PTSD) present with major depressive disorder (MDD). Compared to PTSD alone, patients with comorbid PTSD-MDD demonstrate greater distress and poorer treatment outcome. The goal of this pilot study is to collect preliminary data on the feasibility, safety, and initial efficacy of an…
Condition: Psychiatric Disorders / Depression
Investigator: Michael Grunebaum, MD
Status: Closed
If you're experiencing an acute psychiatric emergency, please stop negotiating this website and call 911 or go to the nearest emergency room. This website is not designed to address an acute psychiatric emergency. Purpose: To find out whether intranasal ketamine, when added to standard antidepressant treatment, improves the outcome of treatment for…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Joshua Kantrowitz, Md
Status: Closed
The purpose of this study is to determine whether the brain wave patterns are improved after administration of CVN058 compared to placebo in subjects with schizophrenia. The study uses electroencephalography (EEG) to measure naturally occurring brain waves as you listen to recorded sounds.
Condition: Psychiatric Disorders
Investigator: Ari Shechter, PhD
Status: Closed
We are currently looking for men and women, age 18-65 y, to participate in a sleep study. To participate you must have experienced insomnia (difficulty falling asleep, staying asleep, or experiencing sleep that is unrefreshing) for at least 1 month. This is a 2-phase outpatient and inpatient study. We will test 2 different non-drug based methods to improve…
Condition: Psychiatric Disorders / Depression
Investigator: Patrick Brown, PhD
Status: Closed
We are studying the relationship between mitochondrial function and the experience of fatigue. Mitochondria are the powerhouses of the cell. Cells within different organs contain hundreds to thousands of mitochondria, which sustain life and fuel energy-dependent processes that we do every day including muscle contraction and cognitive activity. They act…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Guillermo Horga, MD, PhD
Status: Closed
In this study, we are trying to learn more about the symptoms of schizophrenia, specifically to learn how abnormalities in the brain may produce certain experiences that are common in patients with schizophrenia. The study involves clinical interviews, clinical chart review, computer tests, and magnetic resonance imaging (MRI) scans.
Condition: Transplant / Liver Transplant
Investigator: Robert Brown, MD, MPH
Status: Closed
The purpose of this study is to see if study drugs ABT-450/r/ABT-267, and ABT-333 taken with RBV are safe and able to reduce the amount of Hepatitis C Virus (HCV) in subjects' blood over a 24-week treatment period. These drugs are intended to prevent the HCV from multiplying in the human body. Subjects who participate in this study will be expected to…
Condition: Psychiatric Disorders / PTSD
Investigator: Yuval Neria, PhD
Status: Closed
Approximately half of the individuals with Post-traumatic Stress Disorder (PTSD) present with major depressive disorder (MDD). Compared to PTSD alone, patients with comorbid PTSD-MDD demonstrate greater distress and poorer treatment outcome. The goal of this pilot study is to collect preliminary data on the feasibility, safety, and initial efficacy of an…
Condition: Psychiatric Disorders / Depression
Investigator: Joan Prudic, MD
Status: Closed
We are performing functional MRI (fMRI) scans before starting and after completing an acute course of electroconvulsive therapy (ECT) treatment. These scans are being performed to identify brain changes that occur after an acute course of ECT for participants with treatment-resistant depression. We also intend to perform two follow-up fMRI scans at two-…
Condition: Psychiatric Disorders / Schizophrenia
Investigator: Joshua Kantrowitz, Md
Status: Closed
The purpose of this study is to evaluate the efficacy, safety and tolerability of different doses and durations of TV-46000 given by subcutaneous (under the skin) injection as compared to placebo for use as a potential maintenance in adults with schizophrenia.
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
This study is investigating how the brains of people with OCD may change with treatment. The study uses Magnetic Resonance Imaging (MRI) to scan the brain, and the treatment used is a form of Cognitive-Behavioral therapy consisting of Exposure and Ritual Prevention (EX/RP). Participants will undergo a scan, which lasts for approximately 2 hours and takes…
Condition: Psychiatric Disorders
Investigator: Yuval Neria, PhD
Status: Closed
Columbia University Medical Center is presently recruiting individuals ages 18-60, who haveexperienced a traumatic event, to participate in a research treatment study on PTSD. For yourparticipation, you'll receive brief treatment at no cost and $100 in compensation.
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Yagna Pathak, PhD
Status: Closed
The study aims to assess the impact of repetitive transcranial magnetic stimulation (rTMS) on brain imaging and neurophysiological measures in patients with Obsessive-Compulsive Disorder (OCD).
Condition: Transplant / Liver Transplant
Investigator: Robert Brown, MD, MPH
Status: Closed
The purpose of this study is to determine if the administration of non-absorbable antibiotics (rifaximin) for the first three months after liver transplant period will reduce the amount of fibrosis (scarring of the liver) in liver transplant patients with hepatitis C virus (HCV) by lowering serum LPS (a protein in the blood that comes from the bacteria in…
Condition: Psychiatric Disorders / PTSD
Investigator: Yuval Neria, PhD
Status: Closed
Emerging research has demonstrated a relationship between visual attention patterns and anxiety disorders, including PTSD. This study is designed to examine these visual attention patterns using eye-tracking A simple device that monitors eye-movements. The study included two sessions conducted approximately 1 week apart, each no longer than 1 hour. In both…
Condition: Psychiatric Disorders
Investigator: James Whitworth, PhD
Status: Closed
The purpose of this study is to examine the physical and mental effects of exercise in adults who have experienced a recent traumatic event. Participation in this study requires attending 12 sessions at Teachers College Columbia University over the course of six weeks. Each session will last between 30 and 60 minutes. Participants will be compensated with…
Condition: Obstetrics & Gynecology / Reproductive & Hormonal Disorders
Investigator: Rogerio Lobo, MD, FACOG
Status: Closed
The purpose of this study is to evaluate a new experimental (investigational) oral combination hormone drug product containing estradiol (a form of the estrogen) and progesterone (a female hormone that regulates the inner lining of the uterus called the endometrium) for postmenopausal women who have hot flushes. The estradiol and progesterone used in this…
Condition: Psychiatric Disorders / Depression
Investigator: Randy Auerbach, PhD
Status: Closed
We are seeking adolescents ages 13-17 to participate in a study on anhedonia. Anhedonia is the reduced ability to feel pleasure or enjoy things, and is a key feature of depression and other mental illnesses. If you believe your child is experiencing anhedonia, they may be eligible to participate in this study. If your child participates in this study, we…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
The Center for OCD and Related Disorders is currently conducting a study in treating Obsessive-compulsive Disorder (OCD), which is a severe illness characterized by distressing intrusive thoughts, images, or impulses about a variety of themes (e.g., fears of contamination or harm) and repetitive behaviors such as excessive washing or checking. The study is…
Condition: Psychiatric Disorders / Anxiety
Investigator: Jonathan Posner, MD
Status: Closed
The goal of this study is to advance our understanding of how the brain processes emotion in adolescents. Adolescents with and without symptoms of anxiety are invited to participate. This study takes place over two days and includes an evaluation and a brain imaging session. Participants will be compensated up to $250. This study does not provide treatment.
Condition: Psychiatric Disorders / ADD/ADHD
Investigator: Jonathan Posner, MD
Status: Closed
In this study, we are trying to learn more about how stimulant medication produces an improvement in emotional lability (frequent mood changes and excessive emotional reactions) in patients with Attention Deficit Hyperactivity Disorder (ADHD.) Although ADHD is primarily associated with inattention, hyperactivity, and impulsivity, emotional ability plays a…
Condition: Transplant / Liver Transplant
Investigator: Tomoaki Kato, MD
Status: Closed
The purpose of this study is to evaluate the safety and efficacy of FS Grifols as an adjunct to hemostasis during parenchyomous tissue open surgical procedures. Baseline assessments will be performed within 24 hours prior to the scheduled surgery. There will be a physical assessment and a blood draw at the first study visit. Subjects will be randomly…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
The purpose of this pilot research study is to test whether certain components of the marijuana plant, known as "cannabinoids", may help to reduce symptoms in patients with OCD. Specifically, patients enrolled in the study will smoke marijuana containing different concentrations of 2 different cannabinoids, THC and CBD. Both of these agents act on…
Condition: Psychiatric Disorders / ADD/ADHD
Investigator: Jonathan Posner, MD
Status: Closed
Children with Attention-Deficit/Hyperactivity Disorder (ADHD) are typically treated with two types of medications: stimulants and non-stimulants. These medications work in different ways to treat ADHD symptoms, but we do not fully understand the brain mechanisms underlying the medications' effects. This study will use MRI scanning to look at changes in…
Condition: Psychiatric Disorders / Depression
Investigator: Franklin Schneier, MD
Status: Closed
If you are depressed and have not received course of medication treatment for depression in the past, you may be eligible for a study involving brain imaging and research treatment at no cost to you. The research treatment is with a medication that is not FDA-approved for depression. The study uses two types of brain imaging, position emission tomography (…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
Eligible participants will be asked questions about their symptoms, complete questionnaires, and receive sessions of Cognitive-Behavioral therapy consisting of Exposure and Ritual Prevention (EX/RP) accompanied by the use of a mobile app. The purpose of this study is to assess whether the mobile app may be effective in improving symptoms of OCD.
Condition: Psychiatric Disorders / Bipolar Disorder
Investigator: Martin Lan, MD
Status: Closed
We are trying to understand what causes bipolar disorder and how medications treat bipolar depression. If you participate, you will have two different brain scans (MRI and PET scan). You will also have antidepressant treatment for free. We will then be able to see whether information on the brain scans connects with how people do on the medications. The…
Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Pablo Goldberg, M.D.
Status: Closed
The purpose of this study is to assess the effects of a single infusion of ketamine for adolescents and young adults with obsessive-compulsive disorder (OCD). Ketamine is a FDA-approved anesthetic medication that can possibly cause a rapid decrease in OCD symptoms. To be eligible to participate, patients need to have already tried at least one SRI…
Condition: Transplant / Liver Transplant
Investigator: Tomoaki Kato, MD
Status: Closed
The purpose of this study is to determine if Nexavar (sorafenib), the study medication, is effective in preventing cancer recurrence in high risk patients following liver transplantation. The purpose of this study is to determine if sorafenib is a safe and effective treatment option for preventing the recurrence of liver cancer in high risk subjects…
Condition: Psychiatric Disorders / Bipolar Disorder
Investigator: David Hellerstein, MD
Status: Closed
This study is a double-blind and placebo-controlled study to assess its efficacy of the new drug Lumateperone for patients with Major Depressive Episodes associated with Bipolar I and Bipolar II disorder. Lumateperone is thought to exert its antidepressant effect through interaction with sereotogenic, dopaminergic, and glutamergic neurotransmitter targets.…
Condition: Transplant / Liver Transplant
Investigator: Adam Griesemer, MD
Status: Closed
This is a prospective, randomized, multi-center, controlled study for subjects with end stage liver disease who require a liver transplant, comparing whole liver preservation via hypothermic machine perfusion (HMP) using the LLT System with Vasosol with livers preserved via static cold storage (which is standard of care). During Hypothermic Machine…
Condition: Psychiatric Disorders / Depression
Investigator: David Hellerstein, MD
Status: Closed
Patients who are either interested in discontinuing their current antidepressant or have discontinued an antidepressant in the past 6 weeks will be provided with an FDA approved medicine, Vortioxetine (brand name Trintellix). Treatment with Vortioxetine will start after the past antidepressant is discontinued. Vortioxetine dosage is adjustable throughout…