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Relapse Prevention and Changing Habits (REACH+) for Anorexia Nervosa

Condition: Psychiatric Disorders / Eating Disorders

Status: Currently Recruiting

Anorexia Nervosa is a serious illness and relapse rates are high. We have shown that behavioral routines get stuck/entrenched. Our newest research, Relapse Prevention and Changing Habits (REACH+) for Anorexia Nervosa, aims to help patients minimize unhelpful routines and develop more healthful recovery-oriented behavior. Participants will complete initial…

Brain Imaging Study for Participants with Schizophrenia

Condition: Psychiatric Disorders / Schizophrenia

Investigator: Kiyohito Iigaya, PhD

Status: Currently Recruiting

Our lab is conducting brain imaging research studies investigating people's behavior. We are looking for people between the ages of 18 and 65 to be study participants. As a schizophrenia study participant, you will be asked to complete a set of self-report questionnaires probing personality traits. You will also complete a number of computer-based…

IVF Patient Experiences Study

Condition: Obstetrics & Gynecology

Investigator: Abigail Greenleaf, PhD

Status: Currently Recruiting

Columbia University researchers want to hear from current IVF patients about which patient experiences they think should be studied and how. Participation includes a ~1 hour interview on Microsoft Teams about your notable IVF patient experiences and how you might want to share it for future research purposes. Participants will receive $30 for their…

Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

Condition: Cancer / Leukemia

Investigator: Nobuko Hijiya, MD

Status: Currently Recruiting

This study will enroll with children, adolescents and young adults that are less than 22 years old that have returned or 'relapsed' acute myeloid leukemia (AML) diagnoses. Within this group, the study is also targeting those are also unable to receive additional chemotherapy treatments containing anthracycline, which is a type of antibiotic that…

Baby's Heartbeat at Home Study

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: William Fifer, PhD

Status: Currently Recruiting

During pregnancy, a baby's heart rate can tell us a lot about how their brain and body develop. Our team is testing a new, easy-to-use device that you can wear at home to track the baby's heartbeat for up to 24 hours. By using the monitor in your everyday environment, we can learn more about your baby's development in a natural setting,…

Perinatal Heat Preparedness

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Claudia Lugo-Candelas, MS, PhD

Status: Currently Recruiting

The Lugo Lab at Columbia University's Department of Psychiatry is conducting a study to better understand experiences related to extreme heat during pregnancy and to inform the development of heat preparedness resources for perinatal care. We are recruiting English-speaking participants who are 18 years of age or older and reside in New York State and…

ADEPT - Aspirin study to prevent preterm delivery

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Matthew Hoffman, MD, MPH

Status: Currently Recruiting

We are conducting a research trial to determine if low dose Aspirin either 81 or 162 mg will prevent preterm birth in patients who have had a previous preterm birth, still birth, or complications of pregnancy including preeclampsia, small for gestational age baby, fetal growth restriction, or placental abruption. You will be randomized to 81 or 162 mg and…

Have You Had a Hysterectomy, a Tubal Ligation, or Another Type of Sterilization Surgery? Share your experience!

Condition: Obstetrics & Gynecology

Investigator: Xiao Xu, PhD

Status: Currently Recruiting

Columbia University researchers are looking to interview people for a study on patient decisions about whether to remove the fallopian tubes when having a hysterectomy, tubal ligation, or other sterilization surgery. If you are a woman 30-49 years of age, speak English, and have had a hysterectomy (for non-cancer reasons), tubal ligation, or another type of…

Social Media, Brain Processing, and Cortisol in Teen Suicide

Condition: Psychiatric Disorders

Investigator: Samantha Salem, MD

Status: Currently Recruiting

The study uses brain imaging and cortisol to understand risk and protective factors for mental health among adolescents on social media. We are currently recruiting adolescents ages 14-17 who struggle with mental health. To participate in our study, we would ask your child to: 1. Complete a mental health interview (over Zoom), 2. Complete a Magnetic…

A Neuroimaging Study on Brain Chemistry in Depression

Condition: Psychiatric Disorders / Depression

Investigator: Sarah Herzog, PhD

Status: Currently Recruiting

We are conducting a study on depression and suicide risk, and participants can earn up to $300 for taking part. Suicide rates in the U.S. are rising, and new treatments are urgently needed. This study focuses on the brain chemical glutamate, which may play an important role in mood and mental health. We will compare glutamate levels at rest and during…

Fair Start Study - How Environmental Exposures During Pregnancy Influence the Health and Development of Children

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Julie Herbstman, PhD, MSc

Status: Currently Recruiting

You are invited to participate in a research study to understand how environmental exposures during pregnancy influence the health and development of children. This study will begin at pregnancy and follow your child through age 11. A trained research worker will work with you and your child, administering questionnaires to you and developmental evaluations…

Childhood and pregnancy stress and sleep in pregnancy in Latinas

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Claudia Lugo-Candelas, MS, PhD

Status: Currently Recruiting

The Lugo Lab at Columbia University's Department of Psychiatry is conducting a study of stress and sleep in childhood and pregnancy, which will take place over the next year. We are recruiting pregnant people who identify as Latinx/Hispanic. You will be compensated for your time! We are flexible in scheduling convenient times for you to come in. The…

Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias (Children and Young Adults)

Condition: Cancer / Leukemia

Investigator: Nobuko Hijiya, MD

Status: Currently Recruiting

This study is called a screening study and the purpose of this study to find better ways to diagnose and treat leukemia that has come back after treatment or difficult to treat. Bone marrow, blood, and medical information about cancer and treatment will be collected. The results from this screening study may give other information about leukemia that is…

A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML

Condition: Cancer / Leukemia

Investigator: Nobuko Hijiya, MD

Status: Currently Recruiting

This is a phase 1 study for participants with relapsed/refractory acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or juvenile myelomonocytic leukemia (JMML) diagnosis. This study will observe the safety, side effects, and best dose of Imetelstat as an investigational drug, or drug that is not approved by the Food and Drug Administration (FDA…

MIA Study: Understanding the Mother-Baby Relationship During and After Pregnancy

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Marisa Spann, PhD, MPH

Status: Currently Recruiting

Our team is looking at the relationship between a mother and her baby to see how different prenatal and infant experiences affect a baby's brain development. Specifically, we are looking at maternal immune activation (MIA) and how prenatal exposure to MIA can affect a baby's development. For our study, we ask participants to come in for up to 3…

Pregnancy and Mental Health Study

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Cristiane Duarte, PhD

Status: Currently Recruiting

The Center for Intergenerational Psychiatry at Columbia University is recruiting pregnant individuals. We want to learn how feeling worried or anxious (or not having these feelings) may impact pregnant individuals and their babies. We would like to invite people from a wide-range backgrounds who are in between 12 to 34 weeks of their pregnancy to…

Study to test how brain circuits may cause auditory hallucinations

Condition: Psychiatric Disorders / Schizophrenia

Investigator: Guillermo Horga, MD, PhD

Status: Currently Recruiting

In this study, we are trying to learn more about the symptoms of psychosis, specifically to learn how alterations in the brain may produce certain experiences (including voice hearing or auditory hallucinations) that are common in people with psychosis or schizophrenia. The study involves clinical interviews, computer tests, and magnetic resonance imaging (…

The Mindful Brain Project in Teens

Condition: Psychiatric Disorders / Depression

Investigator: Randy Auerbach, PhD

Status: Currently Recruiting

We are recruiting depressed adolescents ages 13-18 years. As a participant in our study, we will: (1) interview your child about current and past thoughts, feelings, and behaviors, (2) teach your child mindfulness strategies, (3) collect brain activity data with MRI (non-invasive) while your child practices mindfulness, and (4) send short surveys to your…

REBIRTH - Study of Bromocriptine in Women with Peripartum Cardiomyopathy (PPCM)

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Jennifer Haythe, MD

Status: Currently Recruiting

We are doing this study to test the use of a drug called bromocriptine for women with a condition called Peripartum cardiomyopathy (PPCM). The study will look at how the heart muscle improves in women taking bromocriptine compared to a group of women given a placebo or inactive pill.

Study of Women After Menopause who are Taking Medication and/or Receiving Counseling/Therapy for Depression

Condition: Psychiatric Disorders / Depression

Investigator: Marcella Walker, MD

Status: Currently Recruiting

Depression and some antidepressants may be associated with an increased risk of breaking a bone. It is not clear why this could be the case. It is possible that depression and/or certain medications used for the treatment of depression cause bone loss, increase the risk of falls, are associated with lower physical activity, or effects on muscle function.…

A Brain Imaging Study of Cannabinoid Medication for Adults with OCD

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)

Investigator: Reilly Kayser, MD

Status: Closed

The Center for OCD Research at Columbia University Irving Medical Center is seeking individuals with obsessive-compulsive disorder (OCD) to participate in a research study, at no cost to you. This study is investigating the medicinal effects of nabilone for OCD symptoms. Nabilone is a synthetic form of tetrahydrocannabinol (THC), which is one of the active…

A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Noelia Zork, MD

Status: Closed

This research study is being done to understand how CPAP for sleep apnea may affect hypertensive disorders of pregnancy and other complications of pregnancy such as gestational diabetes. The purpose of the home sleep test is to find women with sleep apnea. Sleep apnea is when you have one or more pauses in breathing or shallow breaths while you sleep.…

SARS-CoV-2 Vaccine Pregnancy Registry

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Uma Reddy, MD, MPH

Status: Closed

This study will enroll participants who did or did not receive a SARS-CoV-2 vaccine during their pregnancy and have a child who is now 18-30 months of age. In order to assess the long-term outcomes of the offspring of those who received SARS-CoV-2 vaccine in pregnancy, a cohort study examining child developmental outcomes is needed. There are a number of…

Studies of Behavior and Cognition (Participants with Schizophrenia)

Condition: Psychiatric Disorders

Investigator: Kiyohito Iigaya, PhD

Status: Closed

Our lab is conducting research studies investigating people's behavior. We are looking for people between the ages of 18 and 65 who have been diagnosed with Schizophrenia/Depression to be study participants. As a study participant, you will be asked to complete a set of self-report questionnaires probing personality traits and computer-based tasks.…

Study for Youth with Spider Phobia

Condition: Psychiatric Disorders / Anxiety

Investigator: Kate Fitzgerald, MD

Status: Closed

This research study seeks to better understand the biological and behavioral aspects of specific phobia and evaluate how the "Self-Distancing" technique might help youth confront their fears. The study will be conducted at Columbia University in Manhattan. Participation involves completing questionnaires and attending a single visit for a…

MIDAS: Mother and Infant Determinants of Vascular Aging Study

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Noelia Zork, MD

Status: Closed

Women will be enrolled at or prior to prenatal visit at 34-40 weeks gestation with follow-up visits within 48 hours of delivery, and 6 and 12 months postpartum among the mother and infant. Maternal and infant measurements will be conducted at each visit. The purpose of the study is to estimate cardiovascular disease risk in healthy and medically complicated…

Pregnancy and RNA

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: S. Zev Williams, MD, PhD

Status: Closed

Researchers at Columbia are looking at the changes that happen in the placenta when people become pregnant. Participation in this study involves a blood draw at three time points. Participants will be paid $50 at each time point. Participants who complete all three time points will receive bonus compensation.

DOVES - Causes of Stillbirth or Late-Term Miscarriages

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: S. Zev Williams, MD, PhD

Status: Closed

Researchers at Columbia are looking into possible viral causes of stillbirth or late-term miscarriages in patients. We are looking for people who have recently had a late-term pregnancy loss (within the past week). Participation in this research involves a one-time blood draw. Participants will receive $50.

Study Investigating a Treatment for Depression in Patients with Major Depressive Disorder (MDD)

Condition: Psychiatric Disorders / Depression

Investigator: Joshua Berman, MD, PhD

Status: Closed

Are you suffering from chronic depression? We are seeking participants for a depression treatment research study at Columbia University using Transcranial Magnetic Stimulation (TMS). This study develops a more accurate TMS to treat chronic depression. Participation includes clinical assessments and magnetic resonance imaging (MRI). You will receive 27…

MOMS - Supporting Physical and Mental Health During Pregnancy and Postpartum

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Natalie Benda, PhD

Status: Closed

Are you currently pregnant or were you pregnant in the last 2 years? We want to hear from you! We are conducting interviews to understand how we can support physical and mental health during pregnancy and postpartum. Interviews will take place virtually over Zoom or via telephone and last about 60 minutes. There are also options to participate in person (…

Study of Panzyga in Primary Infection Prophylaxis (Prevention) in Patients with Chronic Lymphocytic Leukemia (PRO-SID)

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

This study will be performed to determine if Panzyga (the study drug) can help with preventing infections in patients who have chronic lymphocytic leukemia (CLL). Panzyga is a study drug administered via injection into the vein, which contains human antibodies also called immunoglobulins. It is manufactured by Octapharma. Your participation in this clinical…

Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs)

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Noelia Zork, MD

Status: Closed

GO MOMs is an observational study designed to characterize the glycemic profile of pregnancy using continuous glucose monitoring (CGM) technology in order to develop criteria using CGM measurements and/or early pregnancy oral glucose tolerance testing (OGTT) at 10w0d-14w0d gestation that are predictive, along with clinical factors, of adverse pregnancy…

Ovaprene Non-Hormonal Contraceptive Ring Study

Condition: Obstetrics & Gynecology / Contraception

Investigator: Paula Castano, MD, MPH

Status: Closed

Ovaprene, is an experimental monthly non-hormonal intravaginal contraceptive being developed as a possible new method of birth control. It consists of a round piece of woven material surrounded by a soft, flexible rubber ring. The ring itself is made of a silicone rubber combined with the following ingredients: ferrous gluconate (a type of iron), Vitamin C…

Study Seeking to Evaluate the Effectiveness of LB as a Possible Injection Contraception Method (Females Age 18-40)

Condition: Obstetrics & Gynecology / Contraception

Investigator: Paula Castano, MD, MPH

Status: Closed

The study is looking to evaluate levonogestrel butanoate as a possible new long-acting injectable for birth control. Levonogestrel butanoate is a type of hormone called progestin that has a long history of clinical use in a variety of birth control methods (e.g. pills, intrauterine devices, implants) and its efficacy and safety are well recognized. This…

Study of Quizartinib in Combination with Chemotherapy for Children and Young Adults with Recurrent /Refractory Acute Myeloid Leukemia (AML)

Condition: Cancer / Leukemia

Investigator: Luca Szalontay, MD

Status: Closed

The purpose of this study is to find the best dose of Quizartinib that can be given safely with chemotherapy in children and young adults with acute myeloid leukemia (AML) which has come back or has not responded to the standard therapy. Quizartinib will be given by mouth once a day from Day 6 through Day 28. It will be given in combination with…

Study of Rapamycin in Delaying the Start of Menopause

Condition: Obstetrics & Gynecology / Reproductive & Hormonal Disorders

Investigator: S. Zev Williams, MD, PhD

Status: Closed

Researchers at Columbia are looking at new treatments to help delay the start of menopause. This is a randomized trial where some women will receive medication and some will receive a placebo. The study will last approximately 12 weeks, followed by monthly follow-ups for 6 months. Participants will be compensated $1300 for compensation.

Study of Nivolumab in Combination with 5-Azacytidine in Acute Myeloid Leukemia (AML) - Children and Adults Age 1 to 30

Condition: Cancer / Leukemia

Investigator: Nobuko Hijiya, MD

Status: Closed

The purpose of this study is to find out if the drugs called Nivolumab and 5-Azacytidine can be given safely in children and young adults with Acute Myeloid Leukemia (AML) which has come back after treatment or has not responded to standard therapy. These drugs are thought to work by turning on genes that limit the growth of cancer cells. The study drugs…

Learning and the Brain in Obsessive-Compulsive Disorder (OCD)

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)

Investigator: Amy Rapp, PhD

Status: Closed

The goal of the project is to identify differences in learning in obsessive-compulsive disorder (OCD) by measuring the activity of the brain while participants complete computer tasks. Eligible participants will be asked questions about their medical and psychiatric history and perform tasks on a computer while an electroencephalogram (EEG) is recorded.…

Study of Fedratinib in Combination with Chemotherapy in Patients with Myeloproliferative Neoplasm (MPN) in Accelerated and Blast Phase

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

You are being asked to participate in this study because you have a myeloproliferative neoplasm (MPN) that has transformed to accelerated or blast phase. MPN is a group of diseases in which the bone marrow makes too many blood cells. The different types of MPN are myelofibrosis (MF), essential thrombocythemia (ET), or polycythemia vera (PV). Over time,…

Study of Magrolimab in Combination with Chemotherapy in Patients with Acute Myeloid Leukemia (AML)

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

You are being asked to participate in this study because you have been diagnosed with a blood cancer called Acute Myeloid Leukemia (AML) with or suspected to have a specific gene mutation (TP53 mutation) for which you have not received any prior AML treatment. Tumor protein p53 (TP53) is a gene that codes for a tumor suppressor protein, which is normally…

Study of CGT9486 in Patients with Advanced Systemic Mastocytosis (AdvSM)

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

The purpose of this study is to determine the optimal dose of oral CGT9486 in patients with Advanced Systemic Mastocytosis (AdvSM) and to determine the efficacy of CGT9486 at the selected optimal dose in patients with Advanced Systemic Mastocytosis (AdvSM). This includes Aggressive Systemic Mastocytosis, Advanced Systemic Mastocytosis with an Associated…

Study of Bendamustine/Rituximab Induction Followed by Venetoclax and Rituximab Consolidation for Treatment of Chronic Lymphocytic Leukemia

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

The purpose of this study is to determine the effectiveness of the study treatment- bendamustine and rituximab (BR) followed by venetoclax for 12 months. The combination of the drugs bendamustine and rituximab is a commonly used treatment for your disease. Venetoclax is an oral drug that blocks a protein called BCL-2 which is present on CLL cells. With this…

Smartphone Assessment of Mood

Condition: Psychiatric Disorders / Depression

Investigator: Randy Auerbach, PhD

Status: Closed

This study uses smartphone technology to better understand changes in adolescent moods over time. As a participant in our study, we would: (a) interview your child about current and past thoughts, feelings, and behaviors and (b) collect data from your child's smartphone for 6 months through an app called the Effortless Assessment of Risk States (EARS;…

A Study of Itacitinib for the Prevention of Cytokine Release Syndrome Induced by Immune Effector Cell Therapy

Condition: Cancer / Leukemia

Investigator: Ran Reshef, MD

Status: Closed

Patients who will be receiving immune effector cell (IEC) therapy for the treatment of their cancer (leukemia) are being asked to participate in this study. IEC can produce a harmful side effect called Cytokine Release Syndrome (CRS). CRS involves a release of a large amount of proteins into the bloodstream. This may cause changes in blood pressure and…

Teens' Thoughts About Depression and Mental Health-Related Discrimination

Condition: Psychiatric Disorders

Investigator: Doron Amsalem, MD

Status: Closed

We are conducting a research study to explore discrimination around depression and barriers to care in youth ages 14-18. We will use what we learn to create videos to reduce such discrimination. Parental permission is required for this study. Adolescents (ages 14-18) will participate in an individual interview that will be approximately 45 minutes long. We…

Study of Cabergoline in Adolescents and Adult Women with Endometriosis

Condition: Obstetrics & Gynecology

Investigator: Jin Hee Kim, MD

Status: Closed

In this research study we want to learn more about a potential new therapy for pain associated with endometriosis. We want to determine if a non-hormonal medication, cabergoline, will help patients with endometriosis. Cabergoline is a medication that is approved by the Food and Drug Administration (FDA) for treatment of other medical conditions. In this…

Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS) (ENHANCE)

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to compare the effects, both good and bad, of magrolimab in combination with azacitidine, to those of azacitidine in combination with placebo, to find out which is better for treating patients with MDS (Myelodysplastic Syndrome). Other purposes of this study include determining the quantity of magrolimab in the blood, aspects of…

Experiencing Depression as a Latinx or Black Young Adult

Condition: Psychiatric Disorders / Depression

Investigator: Doron Amsalem, MD

Status: Closed

We are conducting research to explore self-stigma around depression, racial/ethnic and cultural experiences, and barriers to care (e.g., embarrassment, limited access, low expectations/motivation). Self-stigma refers to negative beliefs a person has about themself due to their mental illness. We are looking for Latinx or Black young adults ages 18-25 who…

We Want to Hear Your Thoughts About Stigma and Depression

Condition: Psychiatric Disorders / Depression

Investigator: Doron Amsalem, MD

Status: Closed

We are conducting research to explore the level of self-stigma around depression, racial/ethnic and cultural experiences, and barriers to care (e.g., embarrassment, limited access, low expectations/motivation). Self-stigma refers to negative beliefs a person has about themself due to their mental illness. We are looking for Latinx or Black young adults ages…

Teens' Thoughts About Depression and Mental Health-Related Discrimination

Condition: Psychiatric Disorders / Depression

Investigator: Doron Amsalem, MD

Status: Closed

A Study of GFH009 in Patients With Hematologic Malignancies

Condition: Cancer / Leukemia

Investigator: Andrew Lipsky, MD

Status: Closed

The purpose of this study is to assess the safety, effectiveness, pharmacokinetic (PK how long the drug is in your body and how it is metabolized) and pharmacodynamics (PD where does the drug go in your body and what is its biological effect) of the study drug, GFH009, in patients with relapsed or refractory hematologic malignancies including acute myeloid…

Study of Pembrolizumab in Combination with Chemotherapy for Patients with Endometrial Cancer

Condition: Obstetrics & Gynecology

Investigator: Jason Wright, MD

Status: Closed

We are doing this study because we want to find out if adding a new immunotherapy drug to the usual combination of chemotherapy drugs is better or worse than the usual approach for your endometrial cancer. The usual approach is defined as care most people get for endometrial cancer.

Decision-Making in Bulimia Nervosa (Ages 18+)

Condition: Psychiatric Disorders / Eating Disorders

Investigator: Kelsey Hagan, PhD

Status: Closed

People with bulimia nervosa engage in risky behaviors more often than people without this disorder. We are researching the neurobiological underpinnings of risky decision-making in bulimia nervosa. As a participant in this study, you would: (1) complete a series of questionnaires and interviews, (2) complete an MRI scan (no radiation), and (3) complete…

Decision-Making in Bulimia Nervosa (Ages 13-17)

Condition: Psychiatric Disorders / Eating Disorders

Investigator: Kelsey Hagan, PhD

Status: Closed

People with bulimia nervosa engage in risky behaviors more often than people without this disorder. We are researching the neurobiological underpinnings of risky decision-making in bulimia nervosa. As a participant in this study, your teen would: (1) complete a series of questionnaires and interviews, (2) complete an MRI scan (no radiation), and (3)…

A Study of CYNK-001 in Adults with Newly Diagnosed Acute Myeloid Leukemia

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this clinical research study is to evaluate the safety (any good or bad effects) of CYNK-001 and to assess the effects of CYNK-001 on your Acute Myeloid Leukemia (AML). Also, the study plans to determine the maximum tolerated dose (highest safe dose) of CYNK-001 and assess whether CYNK-001 can eliminate your residual (leftover) disease.…

Study About Extended Nexplanon Use in Females 18-35 Years Old

Condition: Obstetrics & Gynecology

Investigator: Paula Castano, MD, MPH

Status: Closed

Nexplanon a contraceptive implant is currently approved for use up to 3 years. This study is looking to evaluate the contraceptive efficacy of Nexplanon during extended use for 2 more years (5 years total). You may be eligible if you are between the ages of 18-35 and are approaching 36 months from placement of your Nexplanon implant. Study participation…

Depressed Patients: Non-Invasive Study of Brain Oxygen Use

Condition: Psychiatric Disorders / Depression

Investigator: Elizabeth Sublette, MD, PhD

Status: Closed

This research study uses non-invasive brain imaging called functional near-infrared spectroscopy (fNIRS). For fNIRS, a small infrared bulb shines light through the skull, and a special light detector is able to measure oxygen use in the brain. Our goal is to understand oxygen use by brain mitochondria cells in major depression and how this is affected by…

Brain imaging in bipolar depression to understand the role of inflammation in its treatment.

Condition: Psychiatric Disorders / Bipolar Disorder

Investigator: Martin Lan, MD

Status: Closed

This is a research study to understand what causes bipolar disorder and how medications treat bipolar depression. Particularly, we are looking at the importance of inflammation in the process. If you participate, you will receive an experimental medication for your depression named ethyl eicosapentaenoic acid (ethyl EPA), an omega 3 fatty acid. You will…

Study of Drug in Patients with B-Cell Lymphoid Malignancies

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

This research study is evaluating an investigational drug, called cirmtuzumab, in combination with astandard drug, called ibrutinib (Imbruvica), as a possible treatment for patients with CLL/SLL or MCL. All cells in the body receive signals to grow and survive, but sometimes these signals get out of control, causing too much cell growth. When the growth of…

Research Study offering Treatment for Self-Injury (Borderline Personality Disorder)

Condition: Psychiatric Disorders / Borderline Personality Disorder

Investigator: Jeffrey Miller, MD

Status: Closed

The goal of this study is to examine how effective and well-tolerated a possible new treatment for individuals who injure themselves frequently will be. All research procedures can be done from home no in-person visits are required. We are studying a minimal-risk form of electrical brain stimulation called transcranial direct current stimulation, or tDCS.…

Research Study offering Treatment for Self-Injury (Bipolar Disorder)

Condition: Psychiatric Disorders / Bipolar Disorder

Investigator: Jeffrey Miller, MD

Status: Closed

Research Study offering Treatment for Self-Injury (Depression)

Condition: Psychiatric Disorders / Depression

Investigator: Jeffrey Miller, MD

Status: Closed

Study of Vaginal Gel (EVO100) in Prevention of Chlamydia and Gonorrhea (Ages 18-24)

Condition: Obstetrics & Gynecology

Investigator: Paula Castano, MD, MPH

Status: Closed

Protocol is looking to evaluate efficacy of the EVO100 vaginal gel in the prevention of urogenital Chlamydia Trachomatis (CT) and Neisseria gonorrhoeae (GC) infections. You may be eligible if you are between the ages of 18 years or older with a CT and/or GC infectiondiagnosis within the last 16 weeks.

New Birth Control Pill Study

Condition: Obstetrics & Gynecology / Contraception

Investigator: Carolyn Westhoff, MD

Status: Closed

If you are a woman between the ages of 18 and 35, are pre-menopausal, sexually active and do NOT wish to become pregnant, you are invited to see if you may qualify for a research study. The purpose of this research study is to test the effectiveness of an investigational oral birth control pill. If you qualify, you will receive investigational study…

Pediatric Anxiety Treatment Study

Condition: Psychiatric Disorders / Anxiety

Investigator: Amir Levine, MD

Status: Closed

Sertraline (also known as Zoloft) is an FDA approved medication that is used to treat anxiety in children and adolescents. We aim to better understand how children and adolescents with anxiety respond to sertraline and whether we can predict medication response. If your child is eligible, he or she can participate in a research study and will receive both a…

Open-Label Study to Assess the Long-Term Safety of REL-1017 as a Treatment of Major Depressive Disorder

Condition: Psychiatric Disorders / Depression

Investigator: David Hellerstein, MD

Status: Closed

We are currently enrolling individuals with Major Depressive Disorder (MDD) to participate in this research study. This is a one-year open-label study to evaluate the long-term safety and tolerability of an investigational drug called REL-1017 (esmethadone) when taken alone (monotherapy) or when taken with other antidepressants (adjunctive therapy). Study…

Brain Imaging Study and Brief Treatment - People with Hallucinations and Delusions

Condition: Psychiatric Disorders

Investigator: Lawrence Kegeles, MD

Status: Closed

Are you between the ages of 18-35? Do you have schizophrenia or schizoaffective disorder? Researchers at the New York State Psychiatric Institute are currently seeking participants who are interested in a brief trial of anti-psychotic medication. This study will include: - magnetic resonance imaging (MRI) - a physical exam - clinical and neurocognitive…

A Trial of Brexpiprazole and Sertraline in the Treatment of Post-Traumatic Stress Disorder

Condition: Psychiatric Disorders / PTSD

Investigator: Franklin Schneier, MD

Status: Closed

We are currently enrolling individuals with post-traumatic stress disorder (PTSD) to participate in this research study. The purpose of this research study is to evaluate the effectiveness of an investigational medication, brexpiprazole, for PTSD. Eligible participants will be randomly assigned to receive either brexpiprazole, sertraline (also known as…

Dose-Finding Study of Pacritinib in Patients With Leukemia Previously Treated With Ruxolitinib

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

The purpose of this study is to find out what dose of pacritinib is safest and works best for participants. Pacritinib is an experimental drug, which is a drug that is being tested and is not currently approved by the Food and Drug Administration (FDA) in the US. The study will be conducted at about 85 study clinics in North America, Europe, Israel and…

Ketamine for Depression Research Study

Condition: Psychiatric Disorders / Depression

Investigator: Jeffrey Miller, MD

Status: Closed

Do you suffer from depression? Have standard treatments not been helpful? Researchers at Columbia University Irving Medical Center are conducting a study of an experimental antidepressant called ketamine, which can provide rapid relief of depressive symptoms in some patients. The study involves an inpatient stay, during which participants undergo brain…

Study of Uproleselan (GMI-1271) in Combination With Chemotherapy to Treat Relapsed/Refractory Acute Myeloid Leukemia

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to: Test if the lifespan of study participants is increased when uproleselan is added to standard chemotherapy medicines compared to standard chemotherapy alone; test if the number of study participants achieving disease remission is increased when uproleselan is added to standard chemotherapy medicines compared to standard…

Brain Imaging Study of Social Cognition in Individuals with Schizophrenia

Condition: Psychiatric Disorders / Schizophrenia

Investigator: Gaurav Patel, MD, PhD

Status: Closed

Our lab is conducting a series of research studies that investigate how specific brain regions are related to functioning in work, school, and in other social situations. As a study participant, you will be asked to complete clinical and neuropsychological assessments, an eye-tracking task, and a non-invasive MRI scan. Study participants earn between $15-50…

A study for women using contraceptive study drug LF111

Condition: Obstetrics & Gynecology / Contraception

Investigator: Anne Davis, MD

Status: Closed

The purpose of this study is to find out how safe and effective investigational birth control pill, LF111 may be as a contraceptive, how it affects women's menstrual bleeding patterns, and how long LF111 stays in women's bodies. Participants will take the new experimental birth control pill for one year, and will come to the medical center for 8…

Study of Alvocidib When Administered in Sequence After Decitabine in Patients with Myeolodysplastic Syndromes (MDS)

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The purpose of this research study is to determine the preliminary safety and effectiveness (how well something works) of alvocidib when used after the standard drug decitabine in patients with MDS. The study will also gain information about the PK (the process by which a drug is absorbed, distributed, metabolized and eventually eliminated by the body),…

Treatment Study for Adolescents with Depression and Sleep Disturbances

Condition: Psychiatric Disorders / Depression

Investigator: Ellie McGlinchey, PhD

Status: Closed

We are conducting research to compare different ways of improving sleep and mood in teens. Treatment involves Behavioral Sleep Therapy and Interpersonal Psychotherapy for Adolescents targeting: depression trouble falling and staying asleep not feeling rested on waking feeling sleepy during the day. Study Procedures: ~ A free, thorough diagnostic evaluation…

A study for patients with Thrombocytopenia and Primary Myelofibrosis using study drug pacritinib

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

This is a clinical research study for subjects with Myelofibrosis (Primary, Post-Polycythemia Vera, and Post-Essential Thrombocytopenia) and thrombocytopenia. The purpose of this study is to determine if pacritinib is better at reducing spleen size and a reduction in symptoms than the best available therapy. This is a randomized, controlled study.…

A clinical trial investigating the safety and evaluating how well a study drug works in women having difficulty becoming pregnant

Condition: Obstetrics & Gynecology / Fertility

Investigator: Eric Forman, MD, HCLD

Status: Closed

This clinical research study is for women between the ages of 35 and 42 years who are having difficulty becoming pregnant and who would like to receive treatment within an assisted reproductive technology (ART) program in order to become pregnant. The purpose of this research study is to test the safety and effectiveness of an investigation drug called FE…

Study of Investigational New Drug in Subjects with Myelodysplastic Syndromes

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The main purpose of this study is to see how effective an investigational new drug (tipifarnib, the study drug) is to treat myelodysplastic syndrome (MDS). "Investigational" means that tipifarnib has not yet been approved by regulatory authorities such as the United States Food and Drug Administration (FDA) for use outside of clinical trials. You…

Lumateperone for Schizophrenia

Condition: Psychiatric Disorders / Schizophrenia

Investigator: Jeffrey Lieberman, MD

Status: Closed

This study plans to learn more about an investigational new drug called lumateperone tosylate (ITI-007) and may help us find new types of treatment for schizophrenia and schizoaffective disorder.

Ketamine Treatment Study for Adolescents and Young Adults with Obsessive-Compulsive Disorder (OCD)

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)

Investigator: Pablo Goldberg, M.D.

Status: Closed

The purpose of this study is to assess the effects of a single infusion of ketamine for adolescents and young adults with obsessive-compulsive disorder (OCD). Ketamine is a FDA-approved anesthetic medication that can possibly cause a rapid decrease in OCD symptoms. To be eligible to participate, patients need to have already tried at least one SRI…

Contraceptive Vaginal Ring

Condition: Obstetrics & Gynecology / Contraception

Investigator: Paula Castano, MD, MPH

Status: Closed

Hormonal Vaginal Ring for Contraception

A Study of MBG453 in Combination With Hypomethylating Agents in Subjects With Myelodysplastic Syndrome (MDS)

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The purpose of this research study is to find out if the study drug MBG453 in combination with other drugs (decitabine or azacitidine) already commonly used to treat MDS is safe and has beneficial effects in people who have some types of MDS like you (intermediate, high, or very high risk MDS). Subjects will be administered the study treatment as indicated…

MRI Effects of D-cycloserine & Lurasidone in Bipolar Depression

Condition: Psychiatric Disorders / Bipolar Disorder

Investigator: Joshua Kantrowitz, Md

Status: Closed

We will evaluate the D-cycloserine (DCS) and lurasidone with MRI measurement of brain responses to DCS. DCS is a drug that works on the same brain receptor as ketamine. DCS is not approved by the FDA for bipolar depression. Study participants will receive a dose of lurasidone or placebo in one MRI and a dose of DCS in another, followed by an optional follow…

A study for patients with Leukemia using study drug acalabrutinib

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

The purpose of this study, which involves research, is to determine if an experimental drug: acalabrutinib is safe and effective in the treatment of this patients with High Risk Chronic Lymphocytic Leukemia (CLL). Acalabrutinib is an investigational drug, which means that it is still being tested in people and has not been approved by government agencies in…

Study of CPI-0610 in Patients with Myelofibrosis

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

We are doing this study to find out if an investigational drug called CPI-0610 can help with myelofibrosis. An investigational drug is a drug that is not approved for sale in the United States by the Food and Drug Administration (FDA). This study has two groups (arms) one group of patients will be treated with CPI-0610 alone (monotherapy arm) and the other…

Light Therapy Study

Condition: Psychiatric Disorders / Depression

Investigator: Ian Kronish, MD

Status: Closed

This study will allow cancer survivors an opportunity to learn whether light therapy is helpful to them in addressing common concerns of cancer survivors such as fatigue, feeling low, and/or trouble sleeping by engaging in an N-of-1 or individualized trial.

A study for women who want permanent birth control without surgery

Condition: Obstetrics & Gynecology / Contraception

Investigator: Paula Castano, MD, MPH

Status: Closed

The purpose of this study is to test the safety of the FemBloc Permanent Contraceptive System as a method to prevent pregnancy.

E4 Birth Control Pill Study

Condition: Obstetrics & Gynecology / Contraception

Investigator: Carolyn Westhoff, MD

Status: Closed

This study is studying the effectiveness and safety of a new birth control pill. The pill contains two hormones, drospirenone (a progestin) and estetrol (an estrogen), which combine to prevent pregnancy. Scientists think that estetrol may be safer and have more benefits than other estrogen hormones. The study lasts about one year, and you will come in for 7…

Study of PBCAR20A in Participants with Relapsed/Refractory Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Condition: Cancer / Leukemia

Investigator: Ran Reshef, MD

Status: Closed

The purpose of this research study is to obtain information on the safety and effectiveness of PBCAR20A to treat certain types of cancers. PBCAR20A is a new investigational treatment for certain types of cancer of the blood, such as leukemia and lymphoma. It is made from a type of blood cells known as T cells. The T cells in PBCAR20A came from healthy…

Combined Prolonged Exposure and Pramipexole Treatment for Patients with PTSD and Depression

Condition: Psychiatric Disorders / Depression

Investigator: Yuval Neria, PhD

Status: Closed

Approximately half of the individuals with Post-traumatic Stress Disorder (PTSD) present with major depressive disorder (MDD). Compared to PTSD alone, patients with comorbid PTSD-MDD demonstrate greater distress and poorer treatment outcome. The goal of this pilot study is to collect preliminary data on the feasibility, safety, and initial efficacy of an…

A study for patients with MDS, Chronic Myelomonocytic Leukemia (CMML) or Acute Myelogenous Leukemia (MDS) using study drug pevonedistat

Condition: Cancer / Leukemia

Investigator: Mark Frattini, MD, PhD

Status: Closed

Pevonedistat is currently being studied in humans with advanced solid tumors and acute myelogenous leukemia (AML). The current study is designed to evaluate pevonedistat in combination with azacitidine in patients with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), and low-blast AML. This study will assess whether taking…

A study for pregnant women to test fetal chromosomal abnormality

Condition: Obstetrics & Gynecology / Prenatal Abnormalities

Investigator: Ronald Wapner, MD

Status: Closed

The purpose of this study is to collect blood samples from women who are pregnant with a fetus that has been confirmed by prenatal microarray testing to have a chromosomal abnormality, such as a microdeletion (missing chromosomes) or microduplication (extra chromosomes). The sponsor of this study, Sequenom Laboratories, will use these samples to develop and…

Study of Avapritinib (BLU-285) in Patients with Advanced Systemic Mastocytosis

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to test the safety and effectiveness of avapritinib (also known as BLU-285) in individuals who have been diagnosed with aggressive systemic mastocytosis (ASM), Systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell Leukemia (MCL). Avapritinib is an experimental drug means that is is not yet known if…

Research Study Offering Treatment for Suicidal Ideation

Condition: Psychiatric Disorders / Depression

Investigator: Michael Grunebaum, MD

Status: Closed

If you're experiencing an acute psychiatric emergency, please stop negotiating this website and call 911 or go to the nearest emergency room. This website is not designed to address an acute psychiatric emergency. Purpose: To find out whether intranasal ketamine, when added to standard antidepressant treatment, improves the outcome of treatment for…

A study for patients with myelodysplastic syndrome or chronic myelomonocytic leukemia using study drug birinapant

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this part of the study is to obtain further information about the safety and effectiveness(how well it works) of azacitidine plus birinapant (the investigational drug), in people with higher-risk myelodysplastic syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMMoL). One of the standard drugs for these diseases is azacitidine which all…

VeraCept Phase III

Condition: Obstetrics & Gynecology / Contraception

Investigator: Paula Castano, MD, MPH

Status: Closed

We are asking you to participate in this research study because you are a woman of child-bearing age or potential and interested in using an intrauterine device (IUD) for birth control for up to 5 years.

Study of Rigosertib in Patients with Myelodysplastic Syndrome (MDS)

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

The purpose of this study is to determine how well a drug called rigosertib works on people with MDS and to study the safety of rigosertib when it is given to people with MDS. Rigosertib is currently being tested in other clinical research studies.

CVN058 Effect on Mismatch Negativity in Schizophrenics

Condition: Psychiatric Disorders / Schizophrenia

Investigator: Joshua Kantrowitz, Md

Status: Closed

The purpose of this study is to determine whether the brain wave patterns are improved after administration of CVN058 compared to placebo in subjects with schizophrenia. The study uses electroencephalography (EEG) to measure naturally occurring brain waves as you listen to recorded sounds.

Depression and Frailty in Older Adults

Condition: Psychiatric Disorders / Depression

Investigator: Patrick Brown, PhD

Status: Closed

The goal of this open-administration treatment study of escitalopram (or duloxetine) is to evaluate the effect of antidepressant medication on treating the syndrome of frailty in older adults with depressive symptoms. Patients with significant depressive symptoms and 1 or more symptoms of the frailty syndrome (exhaustion, decreased energy, weight loss,…

Help us learn how Emergency Contraception (EC) is absorbed

Condition: Obstetrics & Gynecology / Contraception

Investigator: Carolyn Westhoff, MD

Status: Closed

The unintended pregnancy rate is rising despite increased availability and use of different types of emergency contraception (EC) pills. Few studies have addressed reasons for EC failure, yet such an investigation may allow researchers to better understand if EC can be used more successfully.Recently studies have shown that EC failure rates are higher in…

A study for patients with Acute Myeloid Leukemia (AML) using study drug ASP2215

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of the study is to see if a medicine called ASP2215 is both effective and safe as atreatment for AML patients with mutations in FLT3 gene identified by an investigational FLT3Mutation Assay companion diagnostic (a specific way to test your blood or bone marrow, which is used to see if you have a mutation of the FLT3 gene), compared to salvage…

Brain Imaging Study of Hearing Voices

Condition: Psychiatric Disorders / Schizophrenia

Investigator: Guillermo Horga, MD, PhD

Status: Closed

In this study, we are trying to learn more about the symptoms of schizophrenia, specifically to learn how abnormalities in the brain may produce certain experiences that are common in patients with schizophrenia. The study involves clinical interviews, clinical chart review, computer tests, and magnetic resonance imaging (MRI) scans.

Prolonging pregnancy in women with unexpected early labor using study drug Retosiban

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Cynthia Gyamfi Bannerman, MD

Status: Closed

The purpose of this study is to test the effect of a drug called retosiban on stopping preterm labor and delaying the birth of her baby. We will also study the safety of the drug to find out what effects; good or bad, retosiban has on women in preterm labor and their fetuses. A previous small study, involving 93 women with preterm labor, found that…

A study evaluating the effect of Ulipristal Acetate (UPA) on breast cell growth in reproductive aged women for breast cancer prevention.

Condition: Obstetrics & Gynecology

Investigator: Carolyn Westhoff, MD

Status: Closed

The UPA Breast Study will investigate a medication called ulipristal acetate (UPA), which is currently used as an emergency contraceptive and as a treatment for fibroids. The study is designed to investigate 1) whether taking UPA daily can decrease breast cell proliferation compared to traditional combined oral contraceptive pills; and 2) whether MRI can…

Study of Imetelstat in Subjects With Myelodysplastic Syndrome (MDS)

Condition: Cancer / Leukemia

Investigator: Azra Raza, MD

Status: Closed

The purpose of the study is to evaluate the efficacy and safety of imetelstat for the treatment of patients with myelodysplastic syndrome (MDS). All patients participating in Part 1 of this study will get 7.5 mg/kg of imetelstat as a 2-hour intravenous infusion once every 4 weeks. The dose of imetelstat may be increased, held or decreased depending on how…

Combined Prolonged Exposure and Pramipexole Treatment for Patients with PTSD and Depression

Condition: Psychiatric Disorders / PTSD

Investigator: Yuval Neria, PhD

Status: Closed

A study for patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The purpose of this research study is to determine the effectiveness (how well something works) and safety of an investigational compound called alvocidib when used in a combination chemotherapy therapy regimen in patients with acute myeloid leukemia (AML) who test positive for NOXA priming.

A study for healthy women seeking birth control using Agile contraceptive patch, AG200-15

Condition: Obstetrics & Gynecology / Contraception

Investigator: Paula Castano, MD, MPH

Status: Closed

The purpose of this study is to assess the effectiveness of AG200-15 which is an investigational birth control patch. AG200-15 is an investigational birth control patch being developed for use by women who wish to use a skin patch to prevent pregnancy. It contains LNG (levonorgestral) and EE (ethinyl estradiol), which are female sex hormones and are active…

Tracking Brain Changes with Functional MRI (fMRI) Following an Acute Course of Electroconvulsive Therapy (ECT)

Condition: Psychiatric Disorders / Depression

Investigator: Joan Prudic, MD

Status: Closed

We are performing functional MRI (fMRI) scans before starting and after completing an acute course of electroconvulsive therapy (ECT) treatment. These scans are being performed to identify brain changes that occur after an acute course of ECT for participants with treatment-resistant depression. We also intend to perform two follow-up fMRI scans at two-…

A study for patients with newly diagnosed Acute Myeloid Leukemia (AML) using study drug ASP2215

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to see if a medicine called ASP2215 is both safe and effective as atreatment for patients with Acute Myeloid Leukemia (AML). ASP2215 is an experimental drug that is being studied to treat AML. In this study, ASP2215 will be given in addition to a standard chemotherapy regimen that patients could be receiving even if they were…

QUOTABL: Study of Postpartum Hemoglobin Assessment in Patients Delivering at Allen Hospital

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Rachana Gavara, MD

Status: Closed

This is a study of patients delivering at Columbia University Medical Center-Allen Hospital. The investigators will compare the change in maternal hemoglobin from postpartum day 1 to day 2 and also try to find out if there is a correlation between estimated blood loss and measured blood loss.

Study of Combination Treatment to Reduce Occurrence and Severity of Chronic Graft Versus Host Disease (GVHD)

Condition: Cancer / Leukemia

Investigator: Monica Bhatia, MD

Status: Closed

The purpose of this study is to compare two different combinations of treatment plans to a standard transplant procedure in order to see whether one or both of them are better at reducing the occurrence and severity of chronic GVHD. The research portion of this study involves manipulation of your stem cell product by removing T-cells, which cause chronic…

A Study to Test if TV-46000 is Effective for Maintenance Treatment of Schizophrenia

Condition: Psychiatric Disorders / Schizophrenia

Investigator: Joshua Kantrowitz, Md

Status: Closed

The purpose of this study is to evaluate the efficacy, safety and tolerability of different doses and durations of TV-46000 given by subcutaneous (under the skin) injection as compared to placebo for use as a potential maintenance in adults with schizophrenia.

Treatment for Public Speaking Fears

Condition: Psychiatric Disorders / Anxiety

Investigator: Franklin Schneier, MD

Status: Closed

RESEARCH STUDY:Brief Intervention for Public Speaking Fears (IRB#7293).- Are you between the ages of 18 - 60?- Do you have bothersome fears of public speaking?- Are you interested in trying a novel intervention?This research study tests whether a brief intervention using a medication called propranolol is effective at reducing public speaking fears. This…

Birth control research study of an investigational intrauterine copper contraceptive

Condition: Obstetrics & Gynecology / Contraception

Investigator: Carolyn Westhoff, MD

Status: Closed

There are over 62 million US women in their child-bearing years, ages 15-44. Thirty-eight million use some form of contraception which included permanent sterilization (tubal ligation or vasectomyin male partner), contraceptive implants, intrauterine devices, injections, pills, patches, vaginal spermicides, and behavioral methods such as coitus interrupts…

An Efficacy and Safety Trial of Fedratinib in Subjects With Myelofibrosis and Previously Treated With Ruxolitinib (FREEDOM)

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

You are being asked to take part in this study because you have been diagnosed with Myeloproliferative neoplasm (MPN) Associated Myelofibrosis (your disease) and have received ruxolitinib. The purpose of this study is to confirm how well this study treatment works to reduce your spleen volume, spleen size, what effect the study treatment has on you and…

A study for patients Chronic Lymphocytic Leukemia using study drug BI 836826

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

The purpose of the study is to see if a combination of idelalisib and BI 836826 can help control patients with Chronic Lymphocytic Leukemia (CLL) without serious side effects.

Study of Experimental Drug in Patients with Acute Myeloid Leukemia (AML)

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to test the safety of DCLL9718S at different dose levels, alone or in combination with azacitidine. DCLL9718S is an experimental drug manufactured by Genentech that is designed to inhibit tumor growth. The drug is being tested in clinical trials and has not been approved by the U.S. Food and Drug Administration (FDA) and/or any…

Non-Invasive Stimulation for Obsessive Compulsive Disorder (OCD)

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)

Investigator: Yagna Pathak, PhD

Status: Closed

The study aims to assess the impact of repetitive transcranial magnetic stimulation (rTMS) on brain imaging and neurophysiological measures in patients with Obsessive-Compulsive Disorder (OCD).

A study for women with ovarian cancer who have failed chemotherapy using study drug Liposome-Encapsulated Doxorubicin Hydrochloride

Condition: Obstetrics & Gynecology

Investigator: June Hou, MD

Status: Closed

This research is being done to find out if TOLMAR formulation behaves in the body the same way DOXOrubicin does. This will be done by comparing the amount of doxorubicin in subjects' blood after they are given TOLMAR formulation compared to the amount of doxorubicin in the blood after they are given DOXOrubicin. This is a pharmacokinetic study.…

Study of Alvocidib in Patients with Relapsed/Refractory Acute Myeloid Leukemia Following Treatment with Venetoclax Combination Therapy

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

You are being asked to take part in this study because you have acute myeloid leukemia (AML) that has come back after initial treatment (relapsed) with venetoclax combination therapy or because you did not get a complete response from your initial treatment (refractory) with venetoclax combination therapy. The purpose of this research study is to determine…

Visual Attention in PTSD (PTSD)

Condition: Psychiatric Disorders / PTSD

Investigator: Yuval Neria, PhD

Status: Closed

Emerging research has demonstrated a relationship between visual attention patterns and anxiety disorders, including PTSD. This study is designed to examine these visual attention patterns using eye-tracking A simple device that monitors eye-movements. The study included two sessions conducted approximately 1 week apart, each no longer than 1 hour. In both…

A study for patients acute myeloid leukemia or blastic plasmacytoid dendritic cell neoplasm using study drug SL-401

Condition: Cancer / Leukemia

Investigator: Todd Rosenblat, MD

Status: Closed

The goal of this research study is to find the safest highest dose of SL-401 that can be given to patients with AML or BPDCN. This study will also look at how SL-401 stops or slows leukemia or BPDCN growth and how SL-401 enters and leaves the body. This study will also look at certain proteins in the blood and bone marrow and how the amounts of them might…

A study for pregnant women with high blood pressure using study drug, ATryn

Condition: Obstetrics & Gynecology / Preeclampsia

Investigator: Kirsten Cleary, MD

Status: Closed

The purpose of this study is to evaluate the safety and effectiveness of ATryn, for the treatment of early onset preeclampsia (high blood pressure during pregnancy). ATryn is is currently approved by the Food and Drug Administration (FDA) and is used to prevent blood clots from forming in patients who are having surgery or giving birth to a child. Eligible…

Determining Changing in Cardiovascular and Metabolic Risks in Patients with Chronic Myeloid Leukemia

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

This study will see how the treatment you will receive for your chronic myeloid leukemia affects cardiovascular and metabolic risk factors. The treatments that are being studied are called BCR-ABL1 tyrosine kinase inhibitors (TKIs) (i.e., dasatinib, imatinib, nilotinib). Subjects who are eligible for the study will be starting treatment for chronic myeloid…

Exploring exercise in individuals who have experienced a recent traumatic event

Condition: Psychiatric Disorders

Investigator: James Whitworth, PhD

Status: Closed

The purpose of this study is to examine the physical and mental effects of exercise in adults who have experienced a recent traumatic event. Participation in this study requires attending 12 sessions at Teachers College Columbia University over the course of six weeks. Each session will last between 30 and 60 minutes. Participants will be compensated with…

A study for subjects with acute myeloid leukemia in complete remission using study drug Azacitidine

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to determine if oral azacitidine (CC-486) is safe and effective as maintenance therapy in continuing the response patients had with their last acute myeloid leukemia (AML) treatment and improving the quality of that response. Currently, there is no standard treatment to maintain or improve patient response and patients are…

Study of Extended Use of Mirena Beyond 5 Years in Women

Condition: Obstetrics & Gynecology / Contraception

Investigator: Paula Castano, MD, MPH

Status: Closed

Do You Have a Mirena IUD? You may qualify for a study on the extended use of the Mirena IUD! You may qualify if you are 18 to 33 years old and had your Mirena placed in 2013. Compensation available for time and effort. Find out if you qualify!

A study for patients with acute myeloid leukemia using study drug Venetoclax in combination with Azacitidine

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The purpose of this study is to evaluate the efficacy (how well the study drug works) and safety of venetoclax in combination with azacitidine in subjects who have not been treated for their acute myeloid leukemia (AML). The tolerability (the degree to which evident adverse effects can be tolerated by the patient) of venetoclax will also be evaluated.

Brain Activity Assessment for Depressed Adolescents

Condition: Psychiatric Disorders / Depression

Investigator: Randy Auerbach, PhD

Status: Closed

We are seeking adolescents ages 13-17 to participate in a study on anhedonia. Anhedonia is the reduced ability to feel pleasure or enjoy things, and is a key feature of depression and other mental illnesses. If you believe your child is experiencing anhedonia, they may be eligible to participate in this study. If your child participates in this study, we…

Blocking nocturnal blue light to treat insomnia

Condition: Psychiatric Disorders

Investigator: Ari Shechter, PhD

Status: Closed

We are currently looking for men and women, age 18-65 y, to participate in a sleep study. To participate you must have experienced insomnia (difficulty falling asleep, staying asleep, or experiencing sleep that is unrefreshing) for at least 1 month. This is a 2-phase outpatient and inpatient study. We will test 2 different non-drug based methods to improve…

A study for women with cervical cancer using study drugs VGX-3100 and INO-9012

Condition: Obstetrics & Gynecology

Investigator: Ana Tergas, MD

Status: Closed

The purpose of this research study to find out a new way of treating patients with cervical cancer byactivating their immune system to help their body fight the cancer. VGX-3100 and INO-9012 are aninvestigational drug. This means that the drug has not been approved by the Food and DrugAdministration (FDA) for medical use in patients, but has only been…

A Study Evaluating the Safety and Pharmacokinetics of Atezolizumab Administered With Hu5F9-G4 to Patients With Acute Myeloid Leukemia

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The main purposes of this study are to: 1) understand the safety of atezolizumab given in combination with Hu5F9-G4 and 2) understand the way the body processes atezolizumab and Hu5F9-G4 (pharmacokinetics). This study will also be testing if the combination therapy is effective at treating relapsed or refractory acute myeloid leukemia (R/R AML).…

A study for patients with acute myeloid leukemia (AML) using study drugs Cytarabine and Lintuzumab-Actinium-225

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

This is a clinical research study for subjects with Acute Myeloid Leukemia (AML) who have not received any treatment for their disease and who are over the age of 60. These patients will be treated with low-does cytarabine in combination with Lintuzumab-Ac225. Low dose cytarabine has been investigated in elderly AML patients for at least two decades and is…

Study of Drug in Patients with Acute Myeloid Leukemia (AML)

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The purpose of this study is to measure the effectiveness and safety of an investigational drug called "alovicidib" in combination with cytarabine and daunorubicin in the treatment of AML. Investigational means that this drug has not been approved by the FDA. Cytarabine and daunorubicin are both standard of care treatments for patients with AML.…

Brain imaging study of anxiety symptoms in adolescents

Condition: Psychiatric Disorders / Anxiety

Investigator: Jonathan Posner, MD

Status: Closed

The goal of this study is to advance our understanding of how the brain processes emotion in adolescents. Adolescents with and without symptoms of anxiety are invited to participate. This study takes place over two days and includes an evaluation and a brain imaging session. Participants will be compensated up to $250. This study does not provide treatment.

Mitochondrial Function, Fatigue, and Depression in Later Life

Condition: Psychiatric Disorders / Depression

Investigator: Patrick Brown, PhD

Status: Closed

We are studying the relationship between mitochondrial function and the experience of fatigue. Mitochondria are the powerhouses of the cell. Cells within different organs contain hundreds to thousands of mitochondria, which sustain life and fuel energy-dependent processes that we do every day including muscle contraction and cognitive activity. They act…

A study for women with moderate to severe abdominal cramping during menstruation using a new hormonal vaginal ring

Condition: Obstetrics & Gynecology / Abdominal Cramping

Investigator: Anne Davis, MD

Status: Closed

You may be eligible if you are younger than 51 years old, have regular monthly periods with moderate to severe cramping, and are willing to try a NEW hormonal vaginal ring. The ring contains estrogen and progestin which are hormones found in some types of birth control pills, patches and rings.Participation in the study will consist of 6 study visits and 2…

Study of Acalabrutinib (ACP-196) in Combination with Venetoclax with and without Obinutuzumab in Subjects with Chronic Lymphocytic Leukemia

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

The purpose of this study, which involves research, is to determine if giving an experimental drug called acalabrutinib in combination with venetoclax with and without obinutuzumab is safe and effective for treating people with CLL compared to a combination of bendamustine and rituximab (BR) or a combination of Fludarabine, Cyclophosphamide and Rituximab (…

A study for patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome using study drugs FT 2102

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to test the safety and effectiveness of an experimental medication, FT-2102, in the treatment of acute myeloid leukemia or myelodysplastic syndrome. Patients will receive either FT-2102 alone or in combination with cytarabine or azacitidine, an approved drug commonly used in the treatment of AML and MDS. Subjects will remain on…

A study on women and fertility using online surveys to determine knowledge and attitude

Condition: Obstetrics & Gynecology / Fertility

Investigator: Nataki Douglas, MD, PhD

Status: Closed

The purpose of this study is to survey study participants to determine their knowledge and attitudes towards fertility, and interest in understanding fertility management options. Recruited participants will be contacted via e-mail and invited to participate in online surveys and have hormone markers measured at the Columbia University Medical Center.

Biomarker Study of Philadelphia Chromosome Negative Myeloproliferative Neoplasms (MPN)

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

The purpose of this study is to provide samples for biomarker testing for the different MPD-RC treatment studies. As part of the treatment study you currently participating in, this is an additional research study in which you we will ask for you to donate blood and/or bone marrow samples, two nail clippings, and buccal (cheek) swab. In order to…

Effects of Marijuana on Symptoms of OCD

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)

Investigator: Helen Simpson, MD, PhD

Status: Closed

The purpose of this pilot research study is to test whether certain components of the marijuana plant, known as "cannabinoids", may help to reduce symptoms in patients with OCD. Specifically, patients enrolled in the study will smoke marijuana containing different concentrations of 2 different cannabinoids, THC and CBD. Both of these agents act on…

A study for patients with Acute Myelogenous Leukemia using study drug ABT-199

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to evaluate the safety, and effectiveness of ABT-199 in combination with decitabine and ABT-199 in combination with azacitidine in subjects who have not been treated for their AML. In addition, substances (biomarkers) found in the blood and bone marrow that may indicate the effects or progress of the leukemia and the activity of…

Study Comparing Two Copper IUDs

Condition: Obstetrics & Gynecology / Contraception

Investigator: Paula Castano, MD, MPH

Status: Closed

Columbia University is conducting a contraceptive clinical trial looking at two intrauterine devices, one of which is investigational. Pre-menopausal women ages 16-40 who are generally healthy, sexually active, at risk for pregnancy, and are not at risk for sexually transmitted infections may qualify.

A study of adding study drug Sorafenib to the usual treatment in children and teens with AML (Acute Myeloid Leukemia)

Condition: Cancer / Leukemia

Investigator: Alice Lee, MD

Status: Closed

This study is for children and teens who have been diagnosed with Acute Myeloid Leukemia (AML). AML is a cancer of the bone marrow, the spongy tissue inside the large bones of the body where blood cells are made. In AML, the bone marrow makes large numbers of immature white blood cells called blasts. These blast cells crowd out the normal cells of the bone…

MLN4924 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome (18 to 21 years old)

Condition: Cancer / Leukemia

Investigator: Luca Szalontay, MD

Status: Closed

The purpose of this study is to find the best dose of pevonedistat that can be given safely with chemotherapy in young adults with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) that has either come back or has not responded to the standard therapy. Pevonedistat works by blocking some of the enzymes that are needed for cell growth.

MRI Study Comparing Medications for Children Ages 6-17 with ADHD

Condition: Psychiatric Disorders / ADD/ADHD

Investigator: Jonathan Posner, MD

Status: Closed

Children with Attention-Deficit/Hyperactivity Disorder (ADHD) are typically treated with two types of medications: stimulants and non-stimulants. These medications work in different ways to treat ADHD symptoms, but we do not fully understand the brain mechanisms underlying the medications' effects. This study will use MRI scanning to look at changes in…

Control and Reward Circuits in OCD

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)

Investigator: Helen Simpson, MD, PhD

Status: Closed

This study is investigating how the brains of people with OCD may change with treatment. The study uses Magnetic Resonance Imaging (MRI) to scan the brain, and the treatment used is a form of Cognitive-Behavioral therapy consisting of Exposure and Ritual Prevention (EX/RP). Participants will undergo a scan, which lasts for approximately 2 hours and takes…

A study for Menopausal women using an investigational drug TX004-HR to reduce the frequency of hot flushes.

Condition: Obstetrics & Gynecology / Reproductive & Hormonal Disorders

Investigator: Rogerio Lobo, MD, FACOG

Status: Closed

The purpose of this study is to evaluate a new experimental (investigational) oral combination hormone drug product containing estradiol (a form of the estrogen) and progesterone (a female hormone that regulates the inner lining of the uterus called the endometrium) for postmenopausal women who have hot flushes. The estradiol and progesterone used in this…

Study of PTC299 in Relapsed/Refractory Acute Leukemias

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to find if PTC299 is safe to treat people with relapsed/refractory acute myeloid leukemia (AML) as well to determine the dose of PTC299 that can be given without causing severe side effects. AML is a cancer of the blood and bone marrow (spongy tissue inside bones where blood cells are made). PTC299 is being developed to…

A Mobile App (nOCD) for OCD

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)

Investigator: Helen Simpson, MD, PhD

Status: Closed

Eligible participants will be asked questions about their symptoms, complete questionnaires, and receive sessions of Cognitive-Behavioral therapy consisting of Exposure and Ritual Prevention (EX/RP) accompanied by the use of a mobile app. The purpose of this study is to assess whether the mobile app may be effective in improving symptoms of OCD.

A study for patients with Richter's Transformation (RT) using study drug PNT2258

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

This study is for patients with Richter's transformation (RT). The purpose of this study is to see if a new type of investigational drug called PNT2258 that may be effective in blocking the "on" signal to cancer cells, eventually causing them to die. We are trying to see if PNT2258 provides evidence of anti-tumor effect by measuring what…

VGX-3100 Followed by Electroporation with Cellectra for HPV-related High-Grade Squamous Intraepithelial Lesion of Cervix (REVEAL 2)

Condition: Obstetrics & Gynecology

Investigator: June Hou, MD

Status: Closed

The purpose of this study, which involves research, is being done to see how well an investigational new drug and study device combination will work to treat people with pre-cancerous cells on the cervix caused by human papillomavirus (HPV). The treatment combination is testing a drug, called VGX-3100, given by injection and used with the study device,…

Study of Experimental Drug in Patients with Elevated Thrombocythemia (Too Many Platelets, Leading to Abnormal Blood Clotting or Bleeding)

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

The purpose of this study is to compare the safety, tolerability, and effectiveness of ruxolitinib, an investigational drug, compared to anagrelide, an FDA approved drug. Investigational means that the study drug has not been approved by the FDA for treatment of ET. Patients will be assigned to one of two groups. Group A will receive ruxolitinib and placebo…

Brain imaging in bipolar depression to be able to predict who will respond to antidepressant treatment

Condition: Psychiatric Disorders / Bipolar Disorder

Investigator: Martin Lan, MD

Status: Closed

We are trying to understand what causes bipolar disorder and how medications treat bipolar depression. If you participate, you will have two different brain scans (MRI and PET scan). You will also have antidepressant treatment for free. We will then be able to see whether information on the brain scans connects with how people do on the medications. The…

Computer-based treatment for Post-Traumatic Stress Disorder

Condition: Psychiatric Disorders

Investigator: Yuval Neria, PhD

Status: Closed

Columbia University Medical Center is presently recruiting individuals ages 18-60, who haveexperienced a traumatic event, to participate in a research treatment study on PTSD. For yourparticipation, you'll receive brief treatment at no cost and $100 in compensation.

A study for women with pelvic organ prolapse using urogynecologic surgical mesh Uphold LITE

Condition: Obstetrics & Gynecology

Investigator: Cara Grimes, MD, FACOG

Status: Closed

The purpose of this research study is to compare the treatment device (Uphold LITE) to a traditional native tissue repair procedure for the treatment of symptoms for pelvic organ prolapse (POP). Uphold Lite is a non-absorbable synthetic mesh used to support tissue in women with POP. The device is inserted into the body through an incision in the vaginal…

Study of Vedolizumab in Subjects Undergoing Stem Cell Transplantation

Condition: Cancer / Leukemia

Investigator: Ran Reshef, MD

Status: Closed

The main purpose of this research study is to investigate if a drug called Vedolizumab is safe and effective in preventing acute graft-versus-host disease (attack of donor cells on recipient healthy organs after transplant) of the gut in comparison to placebo (dummy drug). This will be studied in patients undergoing Allogeneic Hematopoietic Stem Cell…

Lumateperone for the Treatment of Bipolar Disorder

Condition: Psychiatric Disorders / Bipolar Disorder

Investigator: David Hellerstein, MD

Status: Closed

This study is a double-blind and placebo-controlled study to assess its efficacy of the new drug Lumateperone for patients with Major Depressive Episodes associated with Bipolar I and Bipolar II disorder. Lumateperone is thought to exert its antidepressant effect through interaction with sereotogenic, dopaminergic, and glutamergic neurotransmitter targets.…

A study for patients with high-risk Myelofibrosis (MF) using study drug imetelstat

Condition: Cancer / Leukemia

Investigator: Mark Heaney, MD, PhD

Status: Closed

The purpose of this study is to find the dose of imetelstat that best treats myelofibrosis. (A doseis a measured amount of a drug taken at one time.) The effects of imetelstat on myelofibrosis as well as any side effects will be explored.

Study of JCAR017 in Subjects with Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

The overall purpose of this part of the study is to determine the best dose of JCAR017 for treating adult participants with relapsed or refractory B-cell Chronic Lymphocytic Leukemia (CLL), and Small Lymphocytic Lymphoma (SLL) and to understand the side effects that participants with your disease may have when they are treated with JCAR017.

Can switching medications to Vortioxetine (brand name Trintellix) assist patients with depression to pursue personal goals?

Condition: Psychiatric Disorders / Depression

Investigator: David Hellerstein, MD

Status: Closed

Patients who are either interested in discontinuing their current antidepressant or have discontinued an antidepressant in the past 6 weeks will be provided with an FDA approved medicine, Vortioxetine (brand name Trintellix). Treatment with Vortioxetine will start after the past antidepressant is discontinued. Vortioxetine dosage is adjustable throughout…

A study for subjects with chronic lymphocytic leukemia using study drug ABT-199

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

The purpose of this study is to evaluate how well the study drug ABT-199 works and safety of ABT-199 in subjects with Chronic Lymphocytic Leukemia (CLL) whose cancer has come back (relapsed) after treatment or no response (refractory) to treatment with B-cell receptor signaling pathway inhibitor therapy, namely Ibrutinib and/or Idelalisib. In addition,…

Study of VGX-3100 for patients with squamous intraepithelial lesion (HSIL) of the vulva

Condition: Obstetrics & Gynecology

Investigator: Ana Tergas, MD

Status: Closed

The purpose of this study is to see how well an investigational new drug and study device combination work to treat women with pre-cancerous cells of the vulva caused by human papillomavirus (HPV) and,thereby avoid surgery. To participate in this study you must have high grade squamous intraepithelial lesion (HSIL) of the vulva caused by HPV types 16 or 18.

A study for healthy, sexually active women using a hormone-releasing intrauterine contraceptive called LevoCept

Condition: Obstetrics & Gynecology / Contraception

Investigator: Carolyn Westhoff, MD

Status: Closed

This is a study looking to evaluate how well a new hormone-releasing Intrauterine Contraceptive called LevoCept works in healthy, sexually active women. The study will consist of 6 study visits including a screening visit prior to enrollment and monthly telephone calls over the course of a year. The study visits will vary but mostly consist of physical and…

Brain imaging in bipolar depression to understand the antidepressant mechanism of lurasidone (Latuda).

Condition: Psychiatric Disorders / Bipolar Disorder

Investigator: Martin Lan, MD

Status: Closed

We are trying to understand what causes bipolar disorder and how medications treat bipolar depression. Particularly, we are looking at the importance of dopamine signaling in the process. If you participate, you will have two different brain scans (MRI and PET scan). You will also have treatment for your depression with an FDA approved medication,…

A study for patients with Acute Myeloid Leukemia (AML) using study drug atezolizumab and guadecitabine

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of this study is to test the safety of the combination of the experimental drugs called atezolizumab and guadecitabine (not yet approved by the U.S. Food and Drug Administration FDA or any other regulatory authority outside the United States) to find out what effects, good or bad, the combination of atezolizumab and guadecitabine has on patients…

Attaining and Maintaining Wellness in OCD

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)

Investigator: Helen Simpson, MD, PhD

Status: Closed

The Center for OCD and Related Disorders is currently conducting a study in treating Obsessive-compulsive Disorder (OCD), which is a severe illness characterized by distressing intrusive thoughts, images, or impulses about a variety of themes (e.g., fears of contamination or harm) and repetitive behaviors such as excessive washing or checking. The study is…

A study for postmenpausal women with symptoms of moderate to severe vaginal pain associated with sexual activity using study drug TX-004HR

Condition: Obstetrics & Gynecology

Investigator: Rogerio Lobo, MD, FACOG

Status: Closed

The purpose of this study is test a new investigational vaginally inserted hormone drug product called TX-004HR on postmenopausal women who have symptoms of vulvar and vaginal atrophy (VVA). After menopause, the amount of estrogen circulating throughout a woman's body decreases and can result in changes in their vaginal tissue known as vulvar and…

Study of ASP2215 (Gilteritinib) Combined with Atezolizumab in Patients with Acute Myeloid Leukemia (AML) with FLT3 Gene Mutations

Condition: Cancer / Leukemia

Investigator: Joseph Jurcic, MD

Status: Closed

The purpose of the study is to see if a medicine called gilteritinib/ASP2215 given in combination with atezolizumab is both effective and safe as a treatment for AML patients with mutations in the FLT3 gene. Some AML patients have a mutation in the gene called FLT3. When patients have a FLT3 mutation, more of the FLT3 protein is on the leukemic cells, or…

Ganaxolone for Post-Partum Depression

Condition: Psychiatric Disorders / Depression

Investigator: David Hellerstein, MD

Status: Closed

This is a pre-marketing (Phase 2A) multi-site study of an investigational drug, ganaxolone, as a potential treatment for non-psychotic post-partum depression. Eligible subjects who agree by signing informed consent will spend four days on the 5-South Research Unit (5-S) of the New York State Psychiatric Institute. For 6 hours they will have an tube in a…

Adults with untreated Acute Myeloid Leukemia who are not considered candidates for intensive remission induction using study drug SGI-110

Condition: Cancer / Leukemia

Investigator: Todd Rosenblat, MD

Status: Closed

The purpose of the study is to test how effective and safe the study drug SGI-110 is compared with current standard treatment for AML. The study drug, SGI-110, is changed in the body into a compound called decitabine. Decitabine is an approved drug in the US for treatment of patients with myelodysplastic syndrome (MDS) and in Europe for treatment of…

Study of HVP16 and HPV18 Vaccine Components in Overwise Healthy Women with Persistent HPV16 or 18 Infection of the Cervix

Condition: Obstetrics & Gynecology

Investigator: Ana Tergas, MD

Status: Closed

The main purpose of this study is to: Find out if the study vaccine therapies cause any side effects (unexpected or unwanted reactions) and how well they are tolerated in women with persistent HPV types 16 or 18 infection of the cervix. Find out whether your body responds (the immune response). Compare the effects (both good and bad) of the study…

Study of sertraline (Zoloft) with ara-C in combination in patients with acute myeloid leukemia (AML)

Condition: Cancer / Leukemia

Investigator: Daniel Lee, MD

Status: Closed

The purpose of the study is to evaluate the safety, tolerability (the effect of the drug on your body), pharmacokinetics (the effect of your body on the drug) and maximum tolerated dose of sertraline in combination with cytosine arabinoside (ara-C, cytarabine) when given to patients with treatment-resistant myeloid leukemia. In addition, the effect of the…

ADHD MRI Study for Stimulant Medication

Condition: Psychiatric Disorders / ADD/ADHD

Investigator: Jonathan Posner, MD

Status: Closed

In this study, we are trying to learn more about how stimulant medication produces an improvement in emotional lability (frequent mood changes and excessive emotional reactions) in patients with Attention Deficit Hyperactivity Disorder (ADHD.) Although ADHD is primarily associated with inattention, hyperactivity, and impulsivity, emotional ability plays a…

A study for women with Pelvic Organ Prolapse who require surgical treatment using Elevate Anterior and Apical Prolapse repair system

Condition: Obstetrics & Gynecology

Investigator: Cara Grimes, MD, FACOG

Status: Closed

The objective of this research study is to compare the treatment success rates and safety of two surgical treatment options: Native Tissue Repair and the Elevate Prolapse Repair System. You maychoose to participate in this research when you and your doctor have determined which surgical treatment option is right for you. The Elevate Prolapse Repair System…

Brain Imaging Study

Condition: Psychiatric Disorders

Investigator: Yuval Neria, PhD

Status: Closed

Columbia University Medical Center is presently recruiting individuals who have experienced trauma to participate in an fMRI research study. For your participation, you will receive up to $270 and an opportunity to advance research in the area of trauma and PTSD. This study involves two visits.

A study for patients with Acute Myeloid Leukemia (AML) using study drug decitabine

Condition: Cancer / Leukemia

Investigator: Richard Carvajal, MD

Status: Closed

This study is for patients with Acute Myeloid Leukemia (AML). The purpose of this study is to determine if decitabine plus JNJ-56022473 can be safely combined and is active for your disease. The study drugs used in this study are JNJ-56022473, an experimental drug and DACOGEN ( also known generic as decitabine), a drug already used to treat your type of…

Study of Drug in Patients with Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

The main goal of this study is to find out about how duvelisib acts in patients with CLL/SLL who were previously treated with a BTKi (Bruton Tyrosine Kinase inhibitor - commercially available ibrutinib or another investigational BTKi). Duvelisib is an investigational drug, meaning that it is not FDA approved, designed to try to stop cancer growth by…

Brief Treatment for People With Social Anxiety

Condition: Psychiatric Disorders / Anxiety

Investigator: Franklin Schneier, MD

Status: Closed

We are currently enrolling individuals with social anxiety disorder to participate in this study. The purpose of this study is to assess whether a brief computer-based research treatment helps improve social anxiety symptoms. For eligible participants, this study will involve a brief, novel research treatment for social anxiety, delivered in 8 or 12…

This study is comparing the outcomes of labor induction versus natural delivery for women with the first pregnancy.

Condition: Obstetrics & Gynecology / Pregnancy

Investigator: Cynthia Gyamfi Bannerman, MD

Status: Closed

The goal of the study is to determine whether coming to the hospital and having the labor started with medicine (i.e., labor induction) at 39 weeks of pregnancy can improve the baby's health at birth when compared with waiting for labor to start on its own.

A study looking at the effectiveness and safety of a new hormonal IUD (Intrauterine Device)

Condition: Obstetrics & Gynecology / Contraception

Investigator: Carolyn Westhoff, MD

Status: Closed

This study will look at the safety and effectiveness of a new hormonal IUD. This IUD is a small device that a clinician will place in your uterus. It contains a progestin (a hormone) that releases a small amount of hormone to prevent pregnancy. Once the device is in, you will come in for periodic study visits over the course of a year.

Internet Survey of Cannabinoid Experiences in OCD

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)

Investigator: Reilly Kayser, MD

Status: Closed

The Center for OCD and Related Disorders at New York State Psychiatric Institute/Columbia University Medical Center is seeking individuals aged 18+ with obsessive-compulsive disorder (OCD) to participate in a survey regarding their experiences with marijuana/cannabis. We hope this study will lead to increased understanding of how these substances affect…

A study for patients with chronic lymphocytic leukemia (CLL) using study drug TDR-1202

Condition: Cancer / Leukemia

Investigator: Nicole Lamanna, MD

Status: Closed

This study is being done to see how well tolerated the investigational drug TGR-1202 is in comparison to other similar therapeutics agents in treating patients with chronic lymphocytic leukemia (CLL).

Brain Imaging and Medication Study for Depression

Condition: Psychiatric Disorders / Depression

Investigator: Franklin Schneier, MD

Status: Closed

If you are depressed and have not received course of medication treatment for depression in the past, you may be eligible for a study involving brain imaging and research treatment at no cost to you. The research treatment is with a medication that is not FDA-approved for depression. The study uses two types of brain imaging, position emission tomography (…

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