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Displaying 1 - 200 of 763
Condition: Healthy Volunteers
Investigator: Steven Kushner, MD, PhD
Status: Currently Recruiting
As an academic medical center, Columbia University is committed to improving patient and population health through research. One way this work is supported is through the Columbia University Biobank (CUB), a secure collection of biological samples and health data that helps researchers better understand disease and develop new treatments. Researchers at…
Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Currently Recruiting
The overall goal of this project is to determine whether the timing of your meals and sleep influences health. We are looking for healthy adults aged 30 and older to participate in a sleep study. Participants must be willing to keep a written food and sleep record for 7 consecutive days. Participants who complete this study will receive a total compensation…
Condition: Cancer / Breast Cancer
Investigator: Rochelle Mendonca, PhD
Status: Currently Recruiting
The Department of Occupational Therapy at Columbia University will be conducting research to understand the impact of aromatase inhibitors (AIs) on performing everyday activities, like bathing and making meals, for women diagnosed with breast cancer. The purpose of this study is to understand how functional performance is impacted by the use of AIs, and its…
Condition: Cancer / Breast Cancer
Investigator: Eileen Connolly, MD, PhD
Status: Currently Recruiting
The purpose of this registry is to keep track of people who are undergoing therapy for ductal carcinoma in situ (DCIS) and who are having molecular testing known as DCISionRT. A Registry is a databank of people who have something in common. Molecular testing looks at how certain genes are used by your tumor cells. The goal of this Registry is to help…
Condition: Healthy Volunteers
Investigator: Ronald Silverman, PhD
Status: Currently Recruiting
The Department of Ophthalmology is conducting an NIH-funded study of 3D ultrasound imaging of the eye, including the vitreous and optic nerve. We are interested in normal subjects without eye disease and individuals with vitreous floaters. The total duration of the exam is approximately 30 minutes. Participation is voluntary and no financial compensation is…
Condition: Cancer / Gynecologic Cancer
Investigator: June Hou, MD
Status: Currently Recruiting
The purpose of the study is to compare how well Rina-S works against ovarian cancer, primary peritoneal cancer, or fallopian tube cancer compared to chemotherapy drugs that are already approved and used for your type of cancer. You have an equal (50:50) chance of getting Rina-S or an approved chemotherapy agent as treatment in this study. Rina-S is not…
Condition: Healthy Volunteers
Investigator: Kiyohito Iigaya, PhD
Status: Currently Recruiting
Our lab is conducting a series of research studies investigating people's memory and decision-making. As a healthy study participant, you will be asked to complete a set of self-report questionnaires probing demographics and personality traits, followed by a number of computer-based tasks. Study participants earn between $15/hour for their time. The…
Condition: Healthy Volunteers
Investigator: Kiyohito Iigaya, PhD
Status: Currently Recruiting
Our lab is conducting a magnetic resonance imaging (fMRI) study to investigate people's memory and decision-making. We are looking for people between the ages of 18 and 60 to be healthy study participants. In this study you will be asked to complete a set of self-report questionnaires probing demographics and personality traits, followed by a number of…
Condition: Healthy Volunteers
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are conducting a research study on how insulin controls blood sugar in both healthy people and those at risk of type 2 diabetes. We are seeking adult volunteers, aged 18-65, who have body mass indices either in the lean range (18-25 kg/m2) or in the obesity range (30-45 kg/m2) but who do not have prediabetes or diabetes. Participants will undergo a…
Condition: Cancer / Leukemia
Investigator: Nobuko Hijiya, MD
Status: Currently Recruiting
This study will enroll with children, adolescents and young adults that are less than 22 years old that have returned or 'relapsed' acute myeloid leukemia (AML) diagnoses. Within this group, the study is also targeting those are also unable to receive additional chemotherapy treatments containing anthracycline, which is a type of antibiotic that…
Condition: Healthy Volunteers
Investigator: Daniel Javitt, MD, PhD
Status: Currently Recruiting
The Division of Experimental Therapeutics in conducting a research study to explore how an experimental procedure, known as transcranial interference stimulation (tIS), affects the brain's ability to process visual information, including recognizing faces. The procedures in this study include 1) interviews, 2) behavioral tests of your ability to detect…
Condition: Cancer / Liver Cancer
Investigator: Elizabeth Verna, MD
Status: Currently Recruiting
This study aims to use new technology involving molecular and imaging tests to help detect liver cancer early in patients. Participants enrolled will participate in it for approximately 5 years. The purpose of this study is to determine if an experimental drug, INT-787, is safe and effective in patients who are hospitalized due to severe alcohol-associated…
Condition: Endocrine & Metabolic Disease
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, ages 18-65, who have obesity with a body mass index of 30-45, and have been diagnosed with, or are at risk for, prediabetes and metabolic…
Condition: Healthy Volunteers
Investigator: Brooke Aggarwal, EdD, MS, FAHA
Status: Currently Recruiting
Women ages 40-65 years may be eligible to participate in a survey about their sleep patterns, stress, and risk factors for heart disease. If you are interested or would like more information, please email us at researchgoesredsurvey@gmail.com.
Condition: Healthy Volunteers
Investigator: Keith Diaz, PhD
Status: Currently Recruiting
U.S. Adults spend on average 11 to 12 hours a day sitting. Daily sedentary behavior is strongly associated with the risk of heart disease. The purpose of the BREAK II research study is to answer two questions: (1) How frequently should periods of prolonged sedentary time be interrupted? and (2) What is the appropriate duration or length of time of these…
Condition: Healthy Volunteers
Investigator: Eldad Hod, MD
Status: Currently Recruiting
We are studying the effects of blood donation. If you are considering donating blood at the next school blood drive, please contact us to determine eligibility. You may qualify for participation whether or not you successfully donate blood and you will be compensated monetarily for your time.
Condition: Healthy Volunteers
Investigator: Marla Hamberger, PhD
Status: Currently Recruiting
We are looking for healthy participants. The purpose of this project is to develop a set of word finding or "naming" tests for Bilingual English-Spanish speakers, ages 35-85. The main tasks involve naming pictures of common objects (e.g. broom) or naming items when given a description (e.g. "what children ride to school in"). There are…
Condition: Healthy Volunteers
Investigator: Dritan Agalliu, PhD
Status: Currently Recruiting
The aim of this study is to understand the mechanisms of secondary effects of traumatic brain injury on the blood-brain barrier and to understand the biochemical differences in the blood of people with Alzheimer's disease and the volunteer group. We will compare biochemical blood differences between a healthy group and traumatic brain injury patients…
Condition: Healthy Volunteers
Investigator: Lila Davachi, PhD
Status: Currently Recruiting
The Davachi Lab is currently recruiting to investigate how individuals process and experience everyday events. The current study involves completing two weeks of "daily diary" survey entries that inquire about your daily experiences, such as such as where you went, what emotions you experienced, or what activities you engaged in. This study is…
Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Currently Recruiting
We are currently looking for healthy, nonsmoking adults ages 40-65 yrs who are dissatisfied with their sleep to participate in a sleep study. Participants should find their sleep not refreshing but not taking external sleep aids. Participants must be willing to eat a specific food for 2 periods of 4 weeks each. Compensation of up to $700 will be provided…
Condition: Healthy Volunteers
Investigator: Sarah Herzog, PhD
Status: Currently Recruiting
We are conducting a study on depression and suicide risk, and participants can earn up to $300 for taking part. Suicide rates in the U.S. are rising, and new treatments are urgently needed. This study focuses on the brain chemical glutamate, which may play an important role in mood and mental health. We will compare glutamate levels at rest and during…
Condition: Healthy Volunteers
Investigator: Jon Freeman, PhD
Status: Currently Recruiting
The Social Cognitive & Neural Sciences Lab at Columbia University's Department of Psychology is conducting a brain imaging study, which will take place over the next 1-3 months. You will be compensated for your time and receive a free video of your brain! We are flexible in scheduling convenient times for you to come in. The study will involve a 2-…
Condition: Healthy Volunteers
Investigator: Julie Herbstman, PhD, MSc
Status: Currently Recruiting
You are invited to participate in a research study to understand how environmental exposures during pregnancy influence the health and development of children. This study will begin at pregnancy and follow your child through age 11. A trained research worker will work with you and your child, administering questionnaires to you and developmental evaluations…
Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Currently Recruiting
We are currently looking for healthy nonsmokers, ages 18-49yrs who are satisfied with their sleep to participate in a sleep study. Participants should typically sleep 7-9 hours/night without external sleep aids. Participants must be willing to change their sleep schedule for approximately 4 weeks. Compensation of up to $1000 will be provided for completing…
Condition: Healthy Volunteers
Investigator: Catherine Clelland, PhD
Status: Currently Recruiting
This research study aims to obtain a greater understanding of the causes of cognitive decline in Alzheimer's disease. We are currently enrolling male and female participants (ages 55 years and older) with Alzheimer's disease, mild cognitive impairment, or healthy controls. Enrolled participants with undergo a small blood draw (about 8 teaspoons)…
Condition: Healthy Volunteers
Investigator: Richard Francis, MD, PhD
Status: Currently Recruiting
This is a Blood Donor Study being conducted at Columbia University Irving Medical Center - New York Presbyterian Hospital. We are interested in recruiting males between the ages of 18-65 who are of African, Asian, Hispanic, Middle Eastern, or Mediterranean descent. The purpose of this research study is to determine whether genetic factors in your DNA affect…
Condition: Cancer / Bladder Cancer
Investigator: Alexander Wei, MD
Status: Currently Recruiting
The purpose of this study is to determine whether using LY4052031 in a type of cancer that may have tumor cells that express a protein called Nectin-4 is safe and how well the cancer responds to the study drug. LY4052031 has not been approved by the US Food and Drug Administration (FDA). This is a first in human study and all of the risks are not fully…
Condition: Healthy Volunteers
Investigator: A. Benjamin Srivastava, MD
Status: Currently Recruiting
Do you ever wonder how brains work? You can earn compensation for completing a study investigating human brain function by having a brain scan. You can earn up to $220 for your participation.
Condition: Healthy Volunteers
Investigator: Michael Lipton, MD PhD
Status: Currently Recruiting
The Lifespan Study uses neuroimaging, cognitive tests, and genomics to explore how the brain's structure and function change throughout life. We are creating a database of typical brain imaging data to study age-related changes. This database will support research, clinical studies, and the creation of new tools for measuring brain health. The Lifespan…
Condition: Healthy Volunteers
Investigator: Norman Kleiman, PhD
Status: Currently Recruiting
We are seeking female menstruating subjects to determine the level of PFAS present in feminine hygiene products. We will ask subjects to provide both a used and unused tampon to measure levels of these chemicals.
Condition: Cancer / Leukemia
Investigator: Nobuko Hijiya, MD
Status: Currently Recruiting
This study is called a screening study and the purpose of this study to find better ways to diagnose and treat leukemia that has come back after treatment or difficult to treat. Bone marrow, blood, and medical information about cancer and treatment will be collected. The results from this screening study may give other information about leukemia that is…
Condition: Healthy Volunteers
Investigator: David Welch
Status: Currently Recruiting
We are seeking subjects for measurements of skin properties using non-invasive devices. Measurements will be made to the forehead and forearm of the participant. These measurements will be performed during a single visit lasting approximately 1 hour.
Condition: Cancer / Pancreatic Cancer
Investigator: Fay Kastrinos, MD
Status: Currently Recruiting
Pancreatic cancer is a deadly disease and the best hope for improving the chances of survival is to find it early. Some patients, called "high risk", have an inherited predisposition to pancreatic cancer. Certain medical centers have started programs where "high risk patients" undergo testing, such as receiving imaging scans, to look for…
Condition: Cancer
Investigator: Lisa Kachnic, MD, FASTRO
Status: Currently Recruiting
In this study, you will be randomized to receive either a brochure or watch a video that discusses radiation and cancer clinical trials. In addition, you will complete questionnaires at seven time points: 1 questionnaire before radiotherapy, 4 questionnaires during the course of radiotherapy and 2 questionnaires at follow-up visits. The questionnaires and…
Condition: Cancer / Lymphoma
Investigator: Nobuko Hijiya, MD
Status: Currently Recruiting
This Phase III trial investigates if the incorporation of immunotherapy will improve progression-free survival (PFS) and maintain overall survival (OS) while simultaneously minimizing long-term morbidity and treatment-related mortality by reducing exposure to radiotherapy and high cumulative chemotherapy doses. The study will enroll patients ages 5 to 60…
Condition: Cancer / Leukemia
Investigator: Nobuko Hijiya, MD
Status: Currently Recruiting
This is a phase 1 study for participants with relapsed/refractory acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or juvenile myelomonocytic leukemia (JMML) diagnosis. This study will observe the safety, side effects, and best dose of Imetelstat as an investigational drug, or drug that is not approved by the Food and Drug Administration (FDA…
Condition: Cancer / Gynecologic Cancer
Investigator: June Hou, MD
Status: Currently Recruiting
The purpose of this clinical research study is to develop a sample collection method that is less invasive than current endometrial sampling methods (uterine sample collection) and develop a diagnostic test from these samples which is as informative in diagnosing the absence of endometrial (uterine) cancer as currently available methods.
Condition: Healthy Volunteers
Investigator: Kiyohito Iigaya, PhD
Status: Currently Recruiting
Our lab is conducting a series of research studies investigating people's behavior. We are looking for people between the ages of 18 and 60. As a healthy study participant, you will be asked to complete a set of self-report questionnaires probing demographics and personality traits, followed by a number of computer-based tasks. Study participants earn…
Condition: Healthy Volunteers
Investigator: Philip De Jager, PhD
Status: Currently Recruiting
Genes and Environment in MS (GEMS) is a longitudinal cohort study investigating how genetics and environment can lead to the onset of Multiple Sclerosis. We are recruiting first-degree relatives (siblings, parents, and children) of people who have been diagnosed with MS. This study involves the collection of magnetic resonance imaging (MRI) of the brain,…
Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Currently Recruiting
We are currently looking for healthy, nonsmoking adults ages 25-65yrs who are dissatisfied with their sleep to participate in a sleep study. Participants should find their sleep not refreshing but not taking external sleep aids. Participants must be willing to eat different foods for two periods of 4 days and undergo testing over a 24-hour period at the…
Condition: Healthy Volunteers
Investigator: Guillermo Horga, MD, PhD
Status: Currently Recruiting
In this study, we are trying to learn more about the symptoms of psychosis, specifically to learn how alterations in the brain may produce certain experiences (including voice hearing or auditory hallucinations) that are common in people with psychosis or schizophrenia. The study involves clinical interviews, computer tests, and magnetic resonance imaging (…
Condition: Healthy Volunteers
Investigator: Julian Agin-Liebes, MD
Status: Currently Recruiting
We are looking for participants for a study on the role of immune response in Parkinsons disease (PD) and Alzheimer's disease (AD). We are inviting people WITH PD, WITH AD, WITH amnestic Mild Cognitive Impairment or WITHOUT PD or AD to come and participate. We will be doing several questionnaires, a motor exam, and a short cognitive assessment, in…
Condition: Healthy Volunteers
Investigator: Scott Small, MD
Status: Currently Recruiting
For over 30 years, The Columbia University Alzheimer's Disease Research Center (ADRC) has worked with thousands of participants who have helped provide important insights into how the brain ages and why Alzheimer's disease may develop. We are actively recruiting adults 65 years of age and older who share our commitment to be part of this…
Condition: Healthy Volunteers
Investigator: Jonathan Overdevest, MD, PhD
Status: Currently Recruiting
The Columbia Otolaryngology Department is interested in understanding how sense of smell relates to memory and neurocognition. Participation will involve answering a series of questionnaires, completing a formal evaluation of your smell with standardized measurements, and complete short smell and memory games. You can participate in this study if you are…
Condition: Healthy Volunteers
Investigator: Patrick Lao, PhD
Status: Currently Recruiting
The purpose of this study is to determine how inflammation is related to changes in the brain that occur during the progression of Alzheimer's disease. If you are eligible for this study, we will ask you to complete 3-4 study visits over the course of about 5 months. Participation includes memory testing, a blood draw, MRI, PET scans, and a lumbar…
Condition: Endocrine & Metabolic Disease
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are conducting a research study on how insulin controls blood sugar in both healthy people and those at risk of type 2 diabetes. We are seeking adult volunteers, aged 18-65, who have body mass indices either in the lean range (18-25 kg/m2) or in the obesity range (30-45 kg/m2) but who do not have prediabetes or diabetes. Participants will undergo a…
Condition: Healthy Volunteers
Investigator: Lila Davachi, PhD
Status: Currently Recruiting
The Davachi Lab is currently running research studies to investigate information processing. These behavioral studies may involve looking at negative, neutral, and positive images on a computer screen (such as objects, faces, or scenes) and/or listening to negative, neutral, and positive auditory sounds (such as tones with varied pitches or human-produced…
Condition: Healthy Volunteers
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are recruiting volunteers, aged 18-70, for a research study on the buildup of excessive liver fat ("fatty liver disease") in people with or at risk for type 2 diabetes because their bodies are resistant to the actions of the blood sugar-lowering hormone, insulin. To do this, we seek to temporarily induce or accentuate insulin resistance in 14…
Condition: Healthy Volunteers
Investigator: Joshua Cook, MD, PhD
Status: Currently Recruiting
We are seeking adult volunteers with body mass index in the obesity range (30-45 kg/m2) to come in for a single study visit where they answer some health questions and have a small volume of blood drawn (25 cc/1.7 tbsp). We will measure levels of the blood sugar-lowering hormone insulin as well as glucose (sugar), certain fats, and other molecules related…
Condition: Healthy Volunteers
Investigator: Pamela Freda, MD
Status: Currently Recruiting
Growth hormone and insulin-like growth-factor 1 (IGF-1) are two hormones that are very important to human growth and metabolism. In disorders of GH and IGF-1 excess and deficiency, significant growth and metabolic abnormalities can develop. This study investigates the effects of GH on the appetite-stimulating hormone AgRP (agouti-related peptide) and the…
Condition: Healthy Volunteers
Investigator: Yufeng Shen, PhD
Status: Currently Recruiting
Study examining the genetic causes of birth defects
Condition: Healthy Volunteers
Investigator: Muredach Reilly, MD
Status: Currently Recruiting
As an academic medical center, we are always working to improve patient and population health. One way that research is supported here is through the Columbia University Biobank (CUB). A biobank is a collection of biological samples and health data gathered during a patient's medical care. Participants in a biobank help researchers find treatments and…
Condition: Healthy Volunteers
Investigator: Daniel Wolpert, PhD
Status: Currently Recruiting
The Sensorimotor Learning Lab at Columbia University is conducting behavioral studies of how our brains control movement. We are looking for volunteers to take part in experiments involving moving in virtual reality, interacting with robotic interfaces and other movement tasks. All the experiments are noninvasive and have been approved by the Columbia IRB.…
Condition: Healthy Volunteers
Investigator: David Brenner, PhD
Status: Currently Recruiting
The purpose of this study is to use blood from healthy people to develop a test to see if people have been exposed to radiation. Between 2 and 3 tablespoons of blood will be drawn from your arm. The blood will be tested with radiation in our laboratory at the Center for Radiological Research at the Columbia University Irving Medical Center. We will measure…
Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, Md
Status: Currently Recruiting
We are looking for individuals 18 to 65 years old who are interested in learning more about HIV prevention and biomedical research studies. We will ask you to complete a brief questionnaire to find out if we can schedule you for a one-on-one, 1.5-hour education visit to learn about the research we do. The education visit will help you decide if you want to…
Condition: Healthy Volunteers
Investigator: Philip De Jager, PhD
Status: Currently Recruiting
The purpose of this study is to establish a collection of biological fluids and associated data from healthy individuals to determine how genetic and environmental variation affects the immune system. Study visits consist of taking vitals and collecting biological fluids, such as blood. You will be compensated for participating in this study.
Condition: Healthy Volunteers
Investigator: Philip De Jager, PhD
Status: Currently Recruiting
The Snapshot study aims to understand brain and spinal cord aging in healthy individuals and individuals with multiple sclerosis (MS). We aim to identify new tools that will help us to achieve successful brain aging in the general population and in people with an underlying autoimmune disease. A critical aspect of this study is that we are looking for…
Condition: Healthy Volunteers
Investigator: Christine Kim Garcia, MD
Status: Currently Recruiting
The purpose of this study is to identify genetic causes of lung diseases and to develop a research repository so that we can better understand, prevent and treat these conditions. You have been asked to join this study as a healthy control. Even though you do not have lung disease, your sample is valuable to us. For example, you may be related to someone…
Condition: Healthy Volunteers
Investigator: Priyanka Ahimaz
Status: Closed
The purpose of this study is to develop written materials and infographics as resources to guide in the understanding of genetics, genomics, and how it relates to one's health and the health of their community. Participants will take part in a 1 hour video call to review educational materials and share your thoughts, emotions, and suggestions for…
Condition: Endocrine & Metabolic Disease / Cushing's Disease
Investigator: Amanda Tsang
Status: Closed
The purpose of this study is to determine if measuring blood levels of proteins called POMC, AgRP, and chromogrannin A (CGA) can be used to diagnose and track tumor growth and recurrence in patients that have ACTH-dependent Cushing's syndrome, non-secreting pituitary tumors, and other neuroendocrine tumors. We invite you to participate if you have: a…
Condition: Healthy Volunteers
Investigator: Jon Freeman, PhD
Status: Closed
The Social Cognitive & Neural Sciences Lab at Columbia University's Department of Psychology is conducting a brain imaging study, which will take place over the next 1-2 months. You will be compensated for your time and receive a free video of your brain! We are flexible in scheduling convenient times for you to come in. The study will involve a 2-…
Condition: Healthy Volunteers
Investigator: Alfredo Spagna, PhD
Status: Closed
The purpose of this research study is understand how three human abilities, attention, visual conscious perception, and imagination, interact with each other to create our behavior.The procedures in this study require collecting your performance data (how fast and accurate you are) in responding to visual stimuli presented on the screen and / or auditory…
Condition: Endocrine & Metabolic Disease
Investigator: Aviva Sopher, MD, MS
Status: Closed
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women ofreproductive age, affecting about 7% of this population when using the strictest diagnostic criteria and frequently presents in adolescence and young adulthood. Diagnostic features of PCOS includehyperandrogenism and ovulatory dysfunction. Additionally, both obese and…
Condition: Endocrine & Metabolic Disease / Cushing's Disease
Investigator: Pamela Freda, MD
Status: Closed
This study is for individuals who have Cushings disease and want to join voluntarily in this study to find out if a study drug called osilodrostat (LCI699) is safe and has beneficial effects in people who have Cushings disease. Cushings disease is a rare but debilitating disease. Cushings disease is caused by a benign tumor of the pituitary gland. The tumor…
Condition: Healthy Volunteers
Investigator: Pamela Freda, MD
Status: Closed
We are looking for healthy people ages 18-70 to study inflammation of fat tissue. Participation includes: fasting over-night before the visit (12 hrs), a blood sample, a DXA test of body composition, an MRI test of body composition, a brief health history questionnaire, height, weight, blood pressure, pulse measurements, and a fat biopsy. For the fat biopsy…
Condition: Healthy Volunteers
Investigator: Pamela Freda, MD
Status: Closed
The purpose of the study is for us to better understand how acromegaly affects bone structure .This study is for particpants who do not have acromegaly. The purpose of this study is to see if there are any differences in bone structure in patients with acromegaly compared to patients with cured acromegaly or without a history of acromegaly. Participants…
Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Closed
The overall goal of this project is to determine whether the timing of your meals influences health. We are currently looking for healthy, non-smoking, men and women to participate in this study. You must regularly sleep at least 7-9 hours/night and regularly eat close to wake time. In addition, you must be willing to come to Columbia University Irving…
Purpose 365: Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP)
Condition: Healthy Volunteers
Investigator: Ellen Morrison, MD, MPH
Status: Closed
PrEP (Pre-Exposure Prophylaxis) is medication that is taken to help prevent HIV infection even if they are exposed to HIV. Research is continuing to find other, more convenient types of PrEP. This study is important because people in many areas of New York City have high rates of HIV acquisition, but use of prevention medication (PrEP) is low. The purpose…
Condition: Cancer
Investigator: Linda Wu, MD
Status: Closed
The purposes of this research study are (1) to learn about the safety and the effects of study drug, PF07985045 on your specific cancer and on your body, with or without combination drugs and (2) to find the best dose for treating your specific type of cancer, as well as treating other types of cancers. This study is divided in two parts: Part 1 and Part 2…
Condition: Cancer / Lung Cancer
Investigator: Catherine Shu, MD
Status: Closed
The purpose of this study is to understand more about the combination of amivantamab and lazertinib in non-small cell lung cancer (NSCLC) who have a specific mutation in the EGFR (epidermal growth factor receptor) gene and have not had prior treatment for their disease. The Food and Drug Administration (FDA) has not approved the combination of amivantamab…
Condition: Cancer
Investigator: Lisa Kachnic, MD, FASTRO
Status: Closed
The purpose of this study is to find out if performing adaptive planning during the treatment anal cancer will decrease the dose of radiation to normal organs and decrease the side effects. In this study, subjects will have a daily adjustment (adaptation) of their radiation plan as the tumor changes during the radiation treatment. The radiation will be…
Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, Md
Status: Closed
This clinical research study is seeking healthy individuals ages 18 to 65 who do not have HIV to help researchers understand how the body's immune system responds to three investigational antibodies (VRC07-523LS, PGT121.414.LS, and PGDM1400LS) against HIV when given in different combinations and doses. This is a Phase 2 study, which means that the…
Condition: Cancer / Gynecologic Cancer
Investigator: Thomas Randall, MD
Status: Closed
The goal of this clinical research study is to compare the outcomes of minimally invasive surgery (the investigational surgery) to laparotomy (the current standard of care) in women with Epithelial Ovarian Cancer (EOC) who receive chemotherapy before and after surgery. Researchers want to learn if one surgery can prevent the disease from returning for…
Condition: Healthy Volunteers
Investigator: Sharon Wardlaw, MD
Status: Closed
The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms. Cerebrospinal fluid neuropeptides, hormones, and protein levels will be measured in subjects before and after bariatric surgery as compared with subjects before and after diet-induced weight loss. Participants in the…
Condition: Cancer / Gynecologic Cancer
Investigator: June Hou, MD
Status: Closed
The main purpose of this study is to learn about the safety of REGN4018 and to find out what dose of REGN4018 can be given alone or in combination with cemiplimab to research subjects with ovarian cancer without too many side effects. The study will also look at the levels of REGN4018 and/or cemiplimab in the body and measure how well your body can remove…
Condition: Healthy Volunteers
Investigator: Gaurav Patel, MD, PhD
Status: Closed
The Dynamic Social Cognition Lab (DSCLab) is currently running a research study to map the parts of the brain involved in how we process social situations. This study involves a combination of clinical, behavioral and magnetic resonance imaging (MRI) sessions. The clinical and behavioral sessions include questionnaires about yourself and your history as…
Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, Md
Status: Closed
This trial is testing two experimental vaccines for HIV called DV700P-RNA and DV701B1.1-RNA. This trial is a Phase 1 study testing whether these vaccines are safe to use in people and can be taken comfortably, as well as how the immune system responds to the vaccines.Both vaccines are made using messenger ribonucleic acid (mRNA) technology. mRNA is a piece…
Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, Md
Status: Closed
The HIV Vaccine Trials Network, Division of AIDS, and Columbia University Irving Medical Center are conducting a trial to learn about the safety and effectiveness of two new experimental HIV vaccines. This is a first-in-human phase 1 clinical trial where we will be testing 2 study vaccines, CH505M5 N197D mRNA-gp160 and CH505 TF mRNA-gp160. The goal is to…
Condition: Cancer
Investigator: Benjamin Herzberg, MD
Status: Closed
The purpose of this study is to study SGN-B6A alone, with pembrolizumab, or with pembrolizumab and one of the chemotherapy drugs (cisplatin or carboplatin). The sponsor wants to find out what its side effects are and if it works for specific types of cancer. It is not yet known if SGN-B6A alone or with other drugs is better or worse than other treatments.…
Condition: Cancer / Lung Cancer
Investigator: Catherine Shu, MD
Status: Closed
The purpose of this study is to evaluate the safety and effectiveness of an experimental drug, BDTX1535, which is not yet approved by the United States Food and Drug Administration (FDA), intreating patients with advanced solid tumors with changes in a protein named epidermal growth factor receptor (EGFR), which may or may not help your condition during…
Condition: Cancer / Gynecologic Cancer
Investigator: Jason Wright, MD
Status: Closed
The purpose of this research study is to learn if sacituzumab govitecan (also called SG) can improve lifespan and delay the growth or spread of the disease in participants with endometrial cancer when compared to chemotherapy (doxorubicin or paclitaxel). Sacituzumab govitecan is a type of drug called an antibody-drug conjugate. An antibody-drug conjugate (…
Condition: Cancer / Lung Cancer
Investigator: Benjamin Herzberg, MD
Status: Closed
The purpose this study to learn more about if a medication called durvalumab will work and be safe for the treatment of non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic) with certain genetic changes when given in combination with tremelimumab and standard chemotherapy. Additionally, this study is being done to better…
Condition: Cancer / Brain Cancer
Investigator: Mikhail Doubrovin, MD
Status: Closed
The purpose of the study is to evaluate the safety of Lutathera alone in patients with recurrent glioblastoma and the combination of Lutathera with radiotherapy with temozolomide (TMZ) in patients with newly diagnosed glioblastoma (GB) and to establish the appropriate dose of this combination. Lutathera is a radioligand therapy, which is a targeted…
Condition: Healthy Volunteers
Investigator: S. Zev Williams, MD, PhD
Status: Closed
Researchers at Columbia are looking at the changes that happen in the placenta when people become pregnant. Participation in this study involves a blood draw at three time points. Participants will be paid $50 at each time point. Participants who complete all three time points will receive bonus compensation.
Condition: Healthy Volunteers
Investigator: Lila Davachi, PhD
Status: Closed
The Davachi Lab is currently running research studies to investigate information processing. These behavioral studies may involve looking at neutral images on a computer screen (such as objects, faces, or scenes) and/or listening to neutral auditory sounds (such as natural ambiance or artificial tones), and making judgments about them. In this study,…
Condition: Cancer
Investigator: Brian Henick, MD
Status: Closed
The purpose of the study is to learn if the study treatments TSC-204-A0201, TSC 200-A020, and TSC-204-C0702 alone or in combination, referred to as T-Plex, are safe and effective in treating your type of cancer. T-Plex has not yet been approved by the Food and Drug Administration (FDA). This is a first-in-human study, which means that these products have…
Condition: Cancer / Prostate Cancer
Investigator: Mark Stein, MD
Status: Closed
The main purpose of the study is to determine whether the study drug, ONC-392, together with a standard of care drug PLUVICTO (Lutetium Lu 177 Vipivotide Tetraxetan), are safe and well tolerated, and whether two drugs are effective in treating prostate cancer, in comparison with the standard of care PLUVICTO alone. ONC-392 has not yet been approved by the…
Condition: Cancer / Multiple Myeloma
Investigator: Divaya Bhutani, MD
Status: Closed
The purpose of this study is to test whether BMS-986393 in combination with other anti-cancer drugs is safe and effective at treating people with multiple myeloma (MM) that has come back after previous treatment (relapsed) or is not responding to current treatment (refractory). The researchers think that the combinations of alnuctamab, mezigdomide, or…
Condition: Healthy Volunteers
Investigator: Daichi Shimbo, MD
Status: Closed
The measurement of blood pressure used to determine if a person has high blood pressure (also known as hypertension) and whether their blood pressure is controlled while taking medications that lower blood pressure. For many people, blood pressure levels are different when measured in a providers office versus during normal daily activities outside of the…
Condition: Healthy Volunteers
Investigator: Marwah Abdalla, MD
Status: Closed
The Center for Behavioral Cardiovascular Health (CBCH) is conducting a research study to examine the impacts on blood pressure when it is measured with and without someone in the room with you. Two-part screening to determine eligibility for this study involves a) answering questionnaires and b) measuring your arm circumference. Participation in the…
Condition: Cancer
Investigator: June Hou, MD
Status: Closed
The purpose of the first part of this study, the Dose Escalation part, is to study and identify the highest tolerable safe dose of MORAb-202. Not all patients will get the same dose of the study drug. At the beginning of the study, a small group of three to six patients will receive an infusion with a low dose of the study drug. If this dose does not cause…
Condition: Healthy Volunteers
Investigator: Ellen Morrison, MD, MPH
Status: Closed
PrEP (Pre-Exposure Prophylaxis) is medication that is taken to prevent HIV if a person is exposed to HIV. Research is ongoing to develop PrEP medications that may be both convenient and effective. This study is important because people who inject drugs face multiple overlapping individual, social, legal, and structural challenges contributing to a…
Condition: Skin Cancer / Melanoma
Investigator: Benjamin Izar, MD
Status: Closed
The purpose of this study is to compare V940 plus pembro given after surgery to a placebo plus pembro given after surgery and to study how effective the study drug is. A placebo looks like a study drug, but it has no active ingredients. V940 has not yet been approved by the Food and Drug Administration (FDA). Pembrolizumab is FDA approved but it has not…
Condition: Cancer / Lung Cancer
Investigator: Catherine Shu, MD
Status: Closed
This study will compare the effectiveness of osimertinib alone to the combination of osimertinib and chemotherapy (carboplatin and pemetrexed) in people with metastatic lung cancer that has a change (mutation) in the gene for the epidermal growth factor receptor (EGFR). Osimertinib alone is the usual treatment for metastatic EGFR-mutant lung cancer. This…
Condition: Healthy Volunteers
Investigator: Adam Brickman, PhD
Status: Closed
The purpose of this study is to better understand how vascular health affects your thinking abilities. We hope that these findings will ultimately lead to treatments aimed to reduce cognitive impairment and dementia. We are actively recruiting adults between the ages of 65 and 90 who note some decline in memory or thinking over the past 3 years and who are…
Condition: Cancer / Gynecologic Cancer
Investigator: June Hou, MD
Status: Closed
The purpose of this research is to learn about what effects, both good and/or bad, an experimental drug called TransCon IL-2 / has when given by itself or in combination with pembrolizumab, SOC chemotherapy, or TransCon TLR7/8 Agonist, or in combination with pembrolizumab and SOC chemotherapy. TransCon IL-2 / works by blocking the reproduction and spread of…
Condition: Cancer / Gastrointestinal
Investigator: Yoanna Pumpalova, MD
Status: Closed
This study is being done to answer the following question: Can we increase the clinical complete response rate (tumor disappears by exam, endoscopy, and imaging) by adding a 3rd drug (irinotecan) to the standard chemotherapy regimens known as FOLFOX or CAPOX, given following long-course chemoradiation for patients with locally advanced rectal cancer? We are…
Condition: Cancer / Multiple Myeloma
Investigator: Divaya Bhutani, MD
Status: Closed
The purpose of this study is to see how teclistamab by itself compares to study treatment combinations that are commonly used to treat multiple myeloma. These study treatment combinations are either pomalidomide, bortezomib and dexamethasone (called PVd) or carfilzomib and dexamethasone (called Kd). The patients will be randomly assigned to one of the study…
Condition: Healthy Volunteers
Investigator: Ellen Morrison, MD, MPH
Status: Closed
PrEP (Pre-Exposure Prophylaxis) is medication that is taken to prevent HIV if a person is exposed to HIV. Research is ongoing to identify PrEP medications that are both convenient and effective. This study is important because women in many areas of New York City have high rates of HIV coupled with low utilization of PrEP. The purpose of HPTN 102/Purpose 3…
Condition: Cancer / Lymphoma
Investigator: Divaya Bhutani, MD
Status: Closed
The purpose of this study is to see if Isatuximab can alter the immune system favorably in patients with multiple myeloma or lymphoma upon recovery from the autologous stem cell transplantation. This study will have two arms. On one arm (control arm), Participants will receive standard transplant procedures and on the other arm (experimental arm),…
Condition: Cancer / Multiple Myeloma
Investigator: Divaya Bhutani, MD
Status: Closed
The purpose of this study is to see if Isatuximab can alter the immune system favorably in patients with multiple myeloma or lymphoma upon recovery from the autologous stem cell transplantation. This study will have two arms. On one arm (control arm), Participants will receive standard transplant procedures and on the other arm (experimental arm),…
Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, Md
Status: Closed
The HIV Vaccine Trials Network (HVTN) and Columbia University Irving Medical Center (CUIMC) are conducting a study to learn about the safety and effectiveness of an experimental HIV vaccine. The study vaccine is a protein vaccine called N332-GT5 gp140. It includes a manmade protein that looks like a protein found on the outside of HIV. The study vaccine is…
Condition: Healthy Volunteers
Investigator: Ellen Morrison, MD, MPH
Status: Closed
Come and talk with us about HIV prevention! HPTN 113-01/DUO is a series of 3 focus group discussions with young Latino/e/x cisgender men and gender nonbinary persons assigned male at birth (AMAB), who have sex with men. The focus groups will be conducted in English or Spanish, include 5-10 people, and be audio-recorded. Participants will be asked to give…
Condition: Healthy Volunteers
Investigator: Elizabeth Oelsner, MD, MPH
Status: Closed
This study is called the COVID-19 Lung Microvascular and Parenchymal Sequelae (LUNG MaPS) Study. The purpose of the study is to learn about the effects of COVID-19 infections on the lungs and heart, and to improve our understanding of why some COVID-19 patients experience ongoing symptoms, or what is often called "long COVID." Hundreds of…
Condition: Cancer / Breast Cancer
Investigator: Eileen Connolly, MD, PhD
Status: Closed
This study is being done to answer the following question: Is treatment with HER2-targeted therapy without radiation therapy as good as the usual treatment of radiation and HER2-targeted therapy in patients with HER2-positive breast cancer who have had surgery, chemotherapy, and HER2-targeted therapy? This study is being done to find out if this approach is…
Condition: Cancer
Investigator: Divaya Bhutani, MD
Status: Closed
The purpose of this study is to see whether Isatuximab can help improve kidney function of participants with Monoclonal Gammopathy of Renal Significance (MGRS). Isatuximab is approved by the Food and Drug Administration (FDA) for the treatment of adult patients with multiple myeloma, but it is not approved by the FDA to treat Monoclonal Gammopathy of Renal…
Condition: Cancer
Investigator: Benjamin Herzberg, MD
Status: Closed
The purpose of this study is to learn how well RP-1664 alone works to treat advanced solid tumor. RP-1664 has not been approved by the Food and Drug Administration (FDA). RP-1664 has not been given to humans prior to this study. Cancers include: bladder cancer, breast cancer, colon and rectal cancer, esophageal cancer, gynecologic cancers, head and neck/…
Condition: Cancer / Breast Cancer
Investigator: Lauren Houghton, PhD
Status: Closed
We are conducting a series of focus group sessions to investigate the attitudes and opinions of young Black women regarding breast cancer, breast cancer risk, and biomarker-based screening to inform current breast cancer screening guidelines.
Condition: Healthy Volunteers
Investigator: Lauren Houghton, PhD
Status: Closed
We are conducting a series of focus group sessions to investigate the attitudes and opinions of young Black women regarding breast cancer, breast cancer risk, and biomarker-based screening to inform current breast cancer screening guidelines.
Condition: Cancer / Kidney Cancer
Investigator: Mark Stein, MD
Status: Closed
The purpose of this study is to determine if the use of immunotherapy nivolumab and the targeted therapy cabozantinib prior to removal of the kidney will increase the number subjects who are without any visible kidney cancer in their body at some point during the course of treatment. The study will also evaluate the changes that nivolumab and cabozantinib…
Condition: Cancer / Skin Cancer
Investigator: Benjamin Izar, MD
Status: Closed
The purpose of this study is to see if IMC-F106C, in combination with nivolumab, works better than the standard therapy (nivolumab alone or in combination with relatlimab) at making tumors stop growing or shrink. IMC-F106C has not yet been approved by the Food and Drug Administration (FDA). Nivolumab and the combination of nivolumab + relatlimab is FDA…
Condition: Cancer / Breast Cancer
Investigator: Dawn Hershman, MD
Status: Closed
The Young, Empowered & Strong (YES) study is opened to women who were diagnosed with breast cancer between the ages of 15 and 39 years. Women will need to be within 3 years of the end of early active treatment (e.g. surgery, chemotherapy not including HER2-directed therapy, radiation), and have no know evidence of breast cancer recurrence. The study…
Condition: Cancer / Brain Cancer
Investigator: Stergios Zacharoulis, MD
Status: Closed
Children and young adults with diffuse midline glioma will be treated with Focused Ultrasound (FUS) with DEFINITY microbubbles and neuro-navigator-controlled sonication. The overall goal of this study is to see if the study treatment plan will improve the outcome of participants with diffuse midline glioma, for which no known cure exists, and determine…
Condition: Cancer
Investigator: Edmond Chan, MD
Status: Closed
The main purpose of the study is to find the optimal dose of HRO761 alone or in combination with tislelizumab or irinotecan that can be given to people with certain cancer types called MSI high or dMMR. The new drug being tested in the study, HRO761, is an oral drug that is called a targeted medicine: this means that it targets particular processes which…
Condition: Cancer / Sarcoma
Investigator: Prabhjot Mundi, MD
Status: Closed
You are being asked to participate in this study because you have been diagnosed with a progressive desmoid tumor. The purpose of this study is to see if the study drug, called AL102 (referred to from now on as the study drug), is safe and effective in people with progressive desmoid tumors. The study will also look at how your body responds to the study…
Condition: Cancer / Gastrointestinal
Investigator: Yoanna Pumpalova, MD
Status: Closed
The purpose of this study is safety, tolerability and efficacy of a combined treatment of LBL-007 and tislelizumab in combination with bevacizumab and capecitabine. LBL-007 and tislelizumab has not yet been approved by the Food and Drug Administration (FDA). Bevacizumab and capecitabine are approved for use in colorectal cancer, but their use in combination…
Condition: Cancer / Bladder Cancer
Investigator: Andrew Lenis, MD
Status: Closed
This study is being done to answer the following question: Can we lower the chance of your bladder cancer growing or spreading by using one type of chemotherapy instilled in the bladder, Gemcitabine and Docetaxel, instead of the usual therapy? The usual approach for patients who are not in a study is treatment with Transurethral surgery of bladder tumor (…
Condition: Cancer / Prostate Cancer
Investigator: Karie D. Runcie, MD
Status: Closed
The purpose of this study is to help researchers understand more about the possible effectiveness and safety of apalutamide when given to patients with or without intermittent Androgen Deprivation Therapy (ADT) to treat metastatic Castration-Sensitive Prostate Cancer (mCSPC). Apalutamide is a type of drug that blocks the action of testosterone. By blocking…
Condition: Cancer
Investigator: Karie D. Runcie, MD
Status: Closed
The purpose of this study is to evaluate the efficacy of the study drug, XL092 alone and/or in combination of other study drugs such as with nivolumab, nivolumab plus ipilimumab, or nivolumab/relatlimab fixed-dose combination as a potential anticancer therapy to treat people with locally advanced or metastatic cancers including advanced renal cell cancer,…
Condition: Cancer
Investigator: Benjamin Izar, MD
Status: Closed
This is a research study to determine how safe and effective a new treatment, called IMC-F106C, is for treating advanced cancers. This study is the first time the study drug is being tested in people. IMC-F106C has been developed to treat cancer by activating the body's own immune system to fight the tumor. The study drug has 2 parts. The first part,…
Condition: Cancer / Kidney Cancer
Investigator: Karie D. Runcie, MD
Status: Closed
The purpose of this study is to study two experimental drugs called canakinumab and spartalizumab produced by Novartis to see if: It is safe and feasible to give canakinumab and spartalizumab prior to radical nephrectomy; canakinumab and spartalizumab can kill cancer cells and bring immune cells into the kidney cancer when given to human subjects prior to…
Condition: Cancer
Investigator: Mark Stein, MD
Status: Closed
The purpose of this study is to assess whether an investigational drug, called XmAb808, given in combination with pembrolizumab, has any effects on your cancer, to determine the best dose of XmAb808 to treat your cancer, and if it is safe and well-tolerated. XmAb808 is an investigational drug being developed for the treatment of advanced solid tumors. An…
Condition: Cancer / Brain Cancer
Investigator: Mary Welch, MD
Status: Closed
The purpose of this study is to test good and bad effects of these two different drugs against meningioma tumors with altered genes. Today, therapy for meningioma is the same for all patients and is not based on tumor genetic testing. This trial is trying to see if tumor genetic testing would be helpful at guiding treatment in patients with meningioma.…
Condition: Cancer
Investigator: Dawn Hershman, MD
Status: Closed
Studies have shown that cancer patients and their spouses may be at high risk for financial problems because of the cost of cancer treatment. This study is being done to answer the following question: Can a financial navigation program help patients and their spouses understand and better manage the financial aspects of cancer care? A financial navigator is…
Condition: Healthy Volunteers
Investigator: Christine Kim Garcia, MD
Status: Closed
The purpose of this study is to identify genetic causes of lung diseases and to develop a research repository so that we can better understand, prevent, and treat these conditions. You have been asked to join this study as a healthy control. Even though you do not have lung disease, your sample is valuable to us because you are related to someone with lung…
Condition: Cancer / Uveal Melanoma
Investigator: Mariam El-Ashmawy, MD, PhD
Status: Closed
This study will develop a data registry of patients diagnosed with uveal melanoma (UM). This registry will provide data that will be used to support the development of novel therapies for this disease. In this study, we are focused on trying to better understand how uveal melanoma behaves and how it is treated at different medical centers around the country.
Condition: Cancer / Gynecologic Cancer
Investigator: Jason Wright, MD
Status: Closed
The main purpose of this study is to determine if two surgical procedures, the usual approach of removing the fallopian tubes and ovaries and the other approach of removing the fallopian tubes at this time with the plan to remove the ovaries at a later time, are no different for ovarian cancer risk reduction in women with BRCA1 mutations who have completed…
Condition: Healthy Volunteers
Investigator: Brooke Aggarwal, EdD, MS, FAHA
Status: Closed
High school students ages 14-18 and their parent(s) may be eligible to participate in a 12-week (consisting of a 6-week pre-pilot and 6-week pilot) sleep health education program.
Condition: Healthy Volunteers
Investigator: Philip De Jager, PhD
Status: Closed
The purpose of this study is to determine whether different genes are related to the amount of immune cell activity that occurs in the brain in patients with Alzheimer's disease. Participation in this study involves memory testing, a blood draw, MRI, and three PET scans. The second PET scan will involve putting a catheter in your wrist to draw blood…
Condition: Cancer / Multiple Myeloma
Investigator: Ran Reshef, MD
Status: Closed
The purpose of this study is to determine if the investigational therapy called bb2121 is effective in treating multiple myeloma. bb2121 is a type of therapy known as chimeric antigen receptor (CAR) T-cell therapy. T cells are a kind of white blood cell which form part of your body's immune system. Your T cells will be separated from the rest of the…
Condition: Cancer
Investigator: June Hou, MD
Status: Closed
This research study has two parts. Participants will be enrolled in the second part of the study. The names of the study drugs are RGX-104, nivolumab, ipilimumab, docetaxel, carboplatin, and pemetrexed. The purpose of the first part of the study is to determine the highest dose of RGX-104 the body can handle. The purpose of the second part is to determine…
Condition: Cancer / Lymphoma
Investigator: Ran Reshef, MD
Status: Closed
Epstein-Barr Virus (EBV) is the virus that causes mononucleosis, also known as mono. Almost all adults have had EBV. For most people, EBV never causes a health problem. However, when their immune system is not working properly (like people who have had a transplant and must be on medications that suppress their immune system), EBV can cause certain diseases…
Condition: Cancer / Lung Cancer
Investigator: Alicia Matthews
Status: Closed
We are conducting a survey to gather feedback about lung cancer patients experience with treatment and the challenges you faced. Your insights can help shape better care for future patients and explore how technology can be of help! The survey takes 30-40 minutes, and eligible participants who complete it will receive a gift card. Interested in…
Condition: Cancer / Liver Cancer
Investigator: Linda Wu, MD
Status: Closed
The purpose of this study is to compare the effects, good or bad, of tiragolumab plus atezolizumab plus bevacizumab versus placebo plus atezolizumab plus bevacizumab on patients with HCC. In this study, participants will be randomized you will get either tiragolumab plus atezolizumab plus bevacizumab or placebo plus atezolizumab plus bevacizumab. A placebo…
Condition: Cancer / Lung Cancer
Investigator: Catherine Shu, MD
Status: Closed
This is a research study evaluating a new investigational drug, called CLN-081. CLN-081 is a type of drug called a tyrosine kinase inhibitor. It targets a mutation in the tumor cell called EGFR exon 20 insertion with the goal to slow down or stop cancer cell growth. It is taken orally (by mouth). There are several different parts to this study, each with…
Condition: Cancer / Brain Cancer
Investigator: Gurcharanjeet Kaur, MD
Status: Closed
The purpose of this study is to find out if REC-2282, an investigational new drug, is an effective and safe treatment in patients with progressive NF2 mutated meningiomas who have either NF2 disease-related meningioma or recurrent sporadic meningiomas that have NF2 mutation. Investigational new drug means a drug that has not been approved as a marketed…
Condition: Cancer / Lung Cancer
Investigator: Catherine Shu, MD
Status: Closed
The purpose of this study to learn more about whether the study drug osimertinib (TAGRISSOTM) is more effective than placebo in participants with epidermal growth factor receptor (EGFR) mutated stage IA2 or IA3 Non-Small Cell Lung Cancer (NSCLC) after complete surgical removal of the tumor. Stages IA2 and IA3 refer to tumor size. A placebo is an inactive…
Condition: Cancer / Brain Cancer
Investigator: Fabio Iwamoto, MD
Status: Closed
The purpose of this study is to see how safe and effective Safusidenib erbumine, the study drug, is in treating brain glioma and to find the recommended dose of the study drug for clinical studies. Safusidenib is not Food and Drug Administration (FDA) approved.
Condition: Cancer / Leukemia
Investigator: Nicole Lamanna, MD
Status: Closed
This study will be performed to determine if Panzyga (the study drug) can help with preventing infections in patients who have chronic lymphocytic leukemia (CLL). Panzyga is a study drug administered via injection into the vein, which contains human antibodies also called immunoglobulins. It is manufactured by Octapharma. Your participation in this clinical…
Condition: Healthy Volunteers
Investigator: Marie-Pierre St-Onge, PhD
Status: Closed
Study of shift workers: We are seeking metabolically-healthy women between the ages of 20 and 55 who work day or night shifts (8 hours or more) to participate in a study at CUIMC/NYP. This study will include 4 separate visits (once per week) to the inpatient unit of Presbyterian Hospital, with each visit lasting a full 24 hours. During the visits, all meals…
Condition: Cancer / Breast Cancer
Investigator: Eileen Connolly, MD, PhD
Status: Closed
This study is being done to answer the following question: Can we lower the chance of your cancer returning by adding the drug olaparib to the usual radiation therapy for your cancer? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your inflammatory breast cancer. The usual approach is…
Condition: Cancer / Lung Cancer
Investigator: Benjamin Herzberg, MD
Status: Closed
The purpose of this study is to assess the benefits and risks of the study drug, adagrasib, when given either by itself or with another drug, nivolumab, to participants with non-small cell lung cancer and a specific cancer mutation, called KRAS G12C, and whether the study drug or the combination may treat or shrink tumors when given before cancer surgery.…
Condition: Cancer
Investigator: Linda Wu, MD
Status: Closed
This study is being done and paid for by Compass Therapeutics (Compass), a company that does drug research studies in order to develop new drugs. Compass is studying a drug called CTX-009. This is an experimental drug being developed to potentially stimulate the immune system to fight against cancer (called, the study drug). Experimental means that the…
Condition: Cancer
Investigator: Brian Henick, MD
Status: Closed
The purpose of this study is to determine the safety and effectiveness of two drugs, either rituximab or tocilizumab, in patients who develop side effects while on treatment with immunotherapy requiring prolonged steroids. Immune-related side effects are caused by activation of the immune system from treatment with immunotherapy. Both rituximab and…
Condition: Cancer / Lung Cancer
Investigator: Stephanie Smith-Marrone, MD
Status: Closed
The purpose of this study is to compare the drugs ramucirumab and pembrolizumab to standard-of-care treatment in patients whose lung cancer has progressed on immunotherapy. The study doctors hope to learn if the drug combination will help patients with stage IV or recurrent non-small cell lung cancer (NSCLC) live longer. The study is set up to find out if…
Condition: Healthy Volunteers
Investigator: Dani Dumitriu, MD, PhD
Status: Closed
This study aims to understand the impact of the COVID-19 pandemic on mother and infant health outcomes in pregnant women delivering at NewYork-Presbyterian Morgan Stanley Children's Hospital or Allen Pavilion Hospital. Data will be collected through online surveys, video visits, and electronic health records.
Condition: Cancer / Brain Cancer
Investigator: Andrew Lassman, MD
Status: Closed
The purpose of this study is to test the safety of a new vaccine, VBI-1901, and to know more about its ability to boost the response of the immune system against Cytomegalovirus. The reason for testing this vaccine in people with a brain tumor is that it might one day be used to boost the ability of the immune system to fight a certain type of brain tumor.…
Condition: Healthy Volunteers
Investigator: Henning Schulzrinne, PhD
Status: Closed
We (the Internet Real-Time Lab (IRT) in the Department of Computer Science at Columbia University) are looking for participants in an experiment evaluating the effects of audio impairments such as background noise, delay, and loss on the intelligibility of first responder communication (firefighters, ambulance, police). The experiment will take place in a…
Condition: Healthy Volunteers
Investigator: Akiva Mintz, MD, PhD
Status: Closed
Neurodegenerative diseases are conditions where the brain cells break down, causing mental and/or physical impairment. Alzheimer's Disease is a neurodegenerative disorder that affects millions of individuals and causes irreversible memory loss and cognitive impairment. Amyotrophic lateral sclerosis is also and incurable disorder that causes patients…
Condition: Cancer
Investigator: Fabio Iwamoto, MD
Status: Closed
With this research study, we want to find out which dose of ST101 is tolerable and effective for people with different types of cancer. We also want to see what the body does to ST101, where ST101 goes in the body, and how long it stays in the body. This study is the first time we have given ST101 to humans. Drugs that can only be used in research are…
Condition: Cancer / Lung Cancer
Investigator: Simon Cheng, MD, PhD
Status: Closed
We are doing this study because we want to find out if MRI brain scans alone is better or worse than MRI brain scans plus preventative brain radiation for patients with small lung cancer. The usual approach for patients with small cell lung cancer is prophylactic cranial irradiation. If you decide to take part in this study, you will either receive PCI for…
Condition: Cancer
Investigator: Brian Henick, MD
Status: Closed
The purpose of this study is to learn more about the safety of a cancer vaccine that teaches the immune system to recognize and possibly destroy tumor cells, and to assess how well the vaccine works. The vaccine has two components. One of them is study drug GRT-C903, and the other is GRT-C904. The vaccine works by stimulating the immune system, which then…
Condition: Healthy Volunteers
Investigator: Sharon Sanz Simon, PhD
Status: Closed
The purpose of this study is to investigate the effect of a web-based (remote, at home) computerized cognitive training protocol on cognitive performance in cognitively healthy older adults. The training will involve multi-tasking in a simulation of daily life situation. If you are eligible, you will be asked to complete 15 web-based sessions, 3 times a…
Condition: Cancer
Investigator: Mark Stein, MD
Status: Closed
This study is being done to answer the following question: What is the highest dose of BAY 1895344 that can be given safely in combination with cisplatin and gemcitabine in patients with advanced solid tumors, including urothelial carcinoma? We are doing this study because we want to find out if this approach is better or worse than the usual approach for…
Condition: Healthy Volunteers
Investigator: Sharon Mannheimer, MD
Status: Closed
We are looking for adult volunteers to help us see if the FDA-approved Bexsero meningitis B vaccine can prevent people from getting gonorrhea infections. There are over 580,000 cases of gonorrhea diagnosed annually in the United States. Gonorrhea infections can significantly affect short and long-term reproductive health and contribute to increasing HIV…
Condition: Cancer / Leukemia
Investigator: Luca Szalontay, MD
Status: Closed
The purpose of this study is to find the best dose of Quizartinib that can be given safely with chemotherapy in children and young adults with acute myeloid leukemia (AML) which has come back or has not responded to the standard therapy. Quizartinib will be given by mouth once a day from Day 6 through Day 28. It will be given in combination with…
Condition: Healthy Volunteers
Investigator: Rebecca Straus Farber, MD
Status: Closed
We are currently recruiting healthy individuals to take part in our research on the effects of probiotics. Our goal is to better understand how the health of the gut microbiome influences the immune system.
Condition: Healthy Volunteers
Investigator: Karen Bell, MD
Status: Closed
We are seeking men & women, ages 55 to 80, who have preclinical Alzheimer's disease for a 216-week treatment, multi-center, double-blind, placebo-controlled, parallel-treatment arm study to determine whether the BAN2401 study drug will reduce the risk of developing Alzheimer's disease. The study participant will receive MRI, and PET scans and…
Condition: Healthy Volunteers
Investigator: Lawrence Honig, MD, PhD
Status: Closed
The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment . Clinical/cognitive, imaging, biomarker, and genetic characteristics will be assessed across two cohorts: early onset Alzheimer's Disease (EOAD)…
Condition: Cancer / Breast Cancer
Investigator: Katherine Crew, MD
Status: Closed
The study is being done to answer the following question: How can we best help women with atypical hyperplasia (AH) or lobular carcinoma in situ (LCIS) and their healthcare providers make informed decisions about whether to take breast cancer risk-reducing pills (drugs to slow or prevent breast cancer from developing)? Participants in this study will learn…
Condition: Cancer / Lymphoma
Investigator: Jennifer Amengual, MD
Status: Closed
This study is being done to determine if a study drug called lenalidomide can be combined with full doses of EPOCH chemotherapy for patients with Adult T-Cell Leukemia-Lymphoma (ATLL), and to define the highest dose and longest duration of lenalidomide that can be given safely in combination with EPOCH. EPOCH chemotherapy is a combination of five…
Condition: Cancer / Prostate Cancer
Investigator: Mark Stein, MD
Status: Closed
The purpose of this study is to determine whether HB-302/HB-301 therapy is safe and well tolerated. This will be the first time HB-302/HB-301 will be tested in humans. HB-302/HB-301 has not yet been approved by the Food and Drug Administration (FDA).
Condition: Healthy Volunteers
Investigator: Sarah O'Shea, MD
Status: Closed
The Parkinson's Progression Markers Initiative (PPMI) seeks to uncover insights into Parkinson's disease (PD) onset and progression that could transform how we diagnose, treat, and potentially prevent PD. PPMI has already contributed to a new understanding around disease biology and experience, and its findings and design have led to more…
Condition: Cancer / Head and Neck Cancer
Investigator: Brian Henick, MD
Status: Closed
The purpose of this research study is to evaluate the safety and effectiveness (how well the study drug works) of NBTRX3 administered via intratumoral injections (injected directly into tumor) and used together with radiotherapy or radiotherapy combined with cetuximab, and how it compares with radiotherapy alone, or radiotherapy combined with cetuximab.…
Condition: Cancer / Bladder Cancer
Investigator: Christopher Anderson, MD
Status: Closed
This study is for patients who have bladder cancer that has not invaded muscle tissue and who have been treated with one or more surgical resections and Bacillus Calmette-Guerin or BCG, which was directly given into the bladder before. The main purpose of this trial is to show that durvalumab is safe when given alone, in combination with BCG treatments, and…
Condition: Cancer / Gynecologic Cancer
Investigator: June Hou, MD
Status: Closed
Participants are being invited to take part in a clinical research study because they have been diagnosed with locally advanced or metastatic solid tumors with mutations in the following genes: MRE11, RAD50, NBN, or CCNE1 amplification. If the participant takes part in the study, they will take an investigational drug referred to as ZN-c3 (Study Drug).…
Condition: Cancer / Gynecologic Cancer
Investigator: June Hou, MD
Status: Closed
The purpose of this research study is to test the safety and determine the highest tolerable dose of SL-172154 (study drug) that can be given with Pegylated Liposomal Doxorubicin (PLD) or Mirvetuximab Soravtansine (MIRV). Another purpose of this study is to understand if SL-127154 and PLD or MIRV is effective in managing ovarian cancer. The study drug, SL-…
Condition: Cancer / Brain Cancer
Investigator: Mary Welch, MD
Status: Closed
The purpose of this study is to evaluate how safe the investigational drug, DSP-0390, is at different doses and to identify a recommended dose that is safe for further study. Investigational means that the study drug is currently being tested and has not been approved for use alone or in combination with any drug by the U.S. Food and Drug Administration (…
Condition: Cancer
Investigator: Prabhjot Mundi, MD
Status: Closed
The purpose of this study is to evaluate the safety and effectiveness of the study drug called atezolizumab in patients with alveolar soft part sarcoma. Atezolizumab works by unblocking your immune system, allowing your immune system cells to recognize and then attack your tumor cells. Atezolizumab could shrink your cancer but it could also have side…
Condition: Healthy Volunteers
Investigator: Chunhua Weng, PhD
Status: Closed
Researchers at Columbia University Irving Medical Center are asking for your help. We are recruiting people 3-75 years of age. We are looking at how a report that contains information about genetic risk for some health conditions may help you and your care providers make decisions about your health. You may be eligible if you receive care at Columbia…
Condition: Healthy Volunteers
Investigator: Joshua Cook, MD, PhD
Status: Closed
We're conducting a research study on how much insulin is needed to control blood sugar in people who are made temporarily resistant to insulin's effects. Insulin is the main hormone (chemical signal) that the body uses to lower the levels of sugar in the blood. We are interested in looking at insulin levels because we think that lowering insulin…
Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, Md
Status: Closed
The purpose of the study is to test an experimental HIV vaccine. The study vaccine is made from two parts: a man-made piece of protein that looks like a protein found on the outside of HIV and an adjuvant. An adjuvant is a substance that helps the immune system respond better. The study will see if the protein and two different amounts of the same adjuvant…
Condition: Healthy Volunteers
Investigator: Daphna Shohamy, PhD
Status: Closed
We are researchers in the Shohamy Lab studying how learning changes across the lifespan. We are looking for participants ages 11-15 for an MRI study. During the MRI study, your child will play computer games and answer questions about their thoughts and feelings. They will also play some games inside an MRI scanner. The total study takes three hours. This…
Condition: Cancer / Multiple Myeloma
Investigator: Divaya Bhutani, MD
Status: Closed
This study will look at the safety of a drug (REGN5458) in patients with multiple myeloma. It will also try to find out what the best dose of REGN5458 is and look for any signs that REGN5458 can help treat your cancer. REGN5458 is investigational, which means it has not been approved by the US Food and Drug Administration (FDA) for any condition.
Condition: Healthy Volunteers
Investigator: Ana Navas-Acien, MD, PHD, MPH
Status: Closed
The use of electronic cigarettes, also known as e-cigs or vaping, has increased among former smokers and young adults who have never smoked. Relatively little is known, however, about their health effects (whether they are adverse, have no effect, or are beneficial). The purpose of this research study is to evaluate (1) the association of e-cig use with…
Condition: Cancer / Leukemia
Investigator: Nobuko Hijiya, MD
Status: Closed
The purpose of this study is to find out if the drugs called Nivolumab and 5-Azacytidine can be given safely in children and young adults with Acute Myeloid Leukemia (AML) which has come back after treatment or has not responded to standard therapy. These drugs are thought to work by turning on genes that limit the growth of cancer cells. The study drugs…
Condition: Cancer / Lung Cancer
Investigator: Catherine Shu, MD
Status: Closed
The purpose of this study is to see whether the medication osimertinib (TAGRISSOTM) alone or when used in combination with chemotherapy is more effective than chemotherapy alone for the treatment of early stage Non-Small Cell Lung Cancer prior to surgery. Osimertinib is an EGFR TKI therapy that targets EGFR mutations. When a tumor is found to have this type…
Condition: Healthy Volunteers
Investigator: Daichi Shimbo, MD
Status: Closed
We are conducting a research study in adults to test whether blood pressure (BP) measured in a clinic setting without a technician present is comparable to blood pressure levels while awake outside of the clinic on an Ambulatory Blood Pressure Monitoring (ABPM) device. We will also test whether asleep blood pressure can be accurately determined using a home…
Condition: Cancer
Investigator: Benjamin Herzberg, MD
Status: Closed
The study is being done to learn how safe and effective the study drug, RP-3500, is when given with either niraparib or olaparib to treat advanced cancer. Niraparib and olaparib belong to a group of drugs called PARP inhibitors. These drugs are designed to block an enzyme called PARP which may stop cancer cells from growing. RP 3500 belongs to a class of…
Condition: Healthy Volunteers
Investigator: Jon Giles, MD
Status: Closed
We are inviting patients without autoimmune disorders to help us compare to rheumatoid arthritis patients with inflammation in soft tissues. With a combination of blood work, a full-body FDG PET-CT scan, questionnaires, and a soft tissue biopsy (from an area around the belly button), we hope to see how tissue inflammation interacts with these multiple areas…
Condition: Skin Cancer / Melanoma
Investigator: Benjamin Izar, MD
Status: Closed
The purpose of this study is to determine the safety and efficacy of CMP-001 when given in combination with nivolumab for patients with unresectable (not capable of being surgically removed) or metastatic (cancer spreads to a different body part from where it started) melanoma. CMP-001 will be given as an injection into the tumor and nivolumab will be given…
Condition: Cancer / Gynecologic Cancer
Investigator: Jason Wright, MD
Status: Closed
XMT-1536 (upifitamab rilsodotin) is a targeted therapy, which means that it is directed specifically at a tumor. It is a type of antibody-drug conjugate; this means it has 2 parts that are joined together into one drug. The first part is an antibody that binds to NaPi2b (sodium-dependent phosphate transporter), a protein on the surface of the cells of your…
Condition: Cancer / Pancreatic Cancer
Investigator: Michael Kluger, MD, MPH
Status: Closed
The purpose of this study is to evaluate how safe and effective the NanoKnife System is at treating Stage 3 pancreatic adenocarcinoma. This is registry study and therefore, the NanoKnife System is not being used for study purposes. The safety and efficacy of this system will be evaluated by comparing survival rates, pain ratings, and number of adverse…
Condition: Healthy Volunteers
Investigator: Julian Agin-Liebes, MD
Status: Closed
FoxBioNet ECV-004 is an observational study sponsored by the Michael J. Fox Foundation for Parkinson's Research. The purpose of this study is to investigate a gene called LRRK2. Mutations in the LRRK2 gene are associated with Parkinson's disease (PD), and mutation carriers have greater LRRK2 protein activity. The goal of this study is to identify…
Condition: Healthy Volunteers
Investigator: Ari Shechter, PhD
Status: Closed
We are seeking healthy female Black Non-Hispanic and White Hispanic control participants who are of normal weight (BMI 18.5-24.9) for a study that is being held by the New York Obesity Nutrition Research Center at Columbia University Medical Center (CUMC) and focuses on eating behavior. In this study, you will be asked to visit CUMC to complete several…
Condition: Cancer / Gastrointestinal
Investigator: Yoanna Pumpalova, MD
Status: Closed
The purpose of this study is to determine if the study drugs, encorafenib, and cetuximab, taken in combination with pembrolizumab would improve compared to the outcome of pembrolizumab alone in study patients. Encorafenib and cetuximab target cancerous BRAF proteins and potentially slow down the growth of cancer cells. Pembrolizumab may help your immune…
Condition: Cancer
Investigator: Mark Stein, MD
Status: Closed
The purpose of this study is to test the safety and effectiveness of ASKG915 at different dose levels to find out what effects, good or bad, this study drug has on you and your cancer. ASKG915 is an experimental treatment that is being developed for treating people with advanced solid tumors. Experimental means the study drug has not been approved for the…
Condition: Cancer / Sarcoma
Investigator: Shaheer Khan, DO
Status: Closed
The purpose of this study is to test the good and bad effects of the drugs called belinostat and SGI-110 (guadecitabine). These drugs could shrink your cancer, but they could also cause side effects. The study doctors hope to learn if the study drugs will shrink the cancer more often than observed with other standard treatment options. We dont know if…
Condition: Cancer
Investigator: Bret Taback, MD
Status: Closed
The primary objective of the EOMI is to acquire tissue and blood, and other biospecimens for research purposes from tests performed for clinical care or for research indications on other research protocols to accelerate our understanding of the molecular basis of early-onset cancers occurring in racial and/or ethnic minority populations through the…
Condition: Cancer / Lung Cancer
Investigator: Catherine Shu, MD
Status: Closed
The purpose of this study is to compare the usual treatment for Non-Small Cell Lung Cancer (osimertinib) to a combination therapy (osimertinib plus ramucirumab). The combination therapy arm is testing if ramucirumab can help osimertinib control the abnormal EGRG protein for a longer time and keep the disease inactive longer. EGRF protein typically helps the…
Condition: Healthy Volunteers
Investigator: Lena Mamykina, PhD
Status: Closed
Seeking participants for a study about how individuals prefer to receive nutrition recommendations to support health management and preferences for visualizing health data. Participants will be invited to complete a 60-minute session to answer questionnaires and evaluate different styles of nutrition recommendations. Alternatively, they will complete one 60…
Condition: Cancer
Investigator: Brian Henick, MD
Status: Closed
This phase Ib trial studies the side effects of nivolumab and to see how well it works in treating patients with autoimmune disorders and cancer that has spread to other places in the body or cannot removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere…
Condition: Healthy Volunteers
Investigator: Ali Gharavi, MD
Status: Closed
The All of Us Research Program has a simple mission. We want to speed up health research breakthroughs. To do this, we are asking one million people to help us lead the way in discovering better care for all of us. The All of Us Research Program is a large research program. The goal is to help researchers understand more about why people get sick or stay…
Condition: Cancer
Investigator: Alexander Wei, MD
Status: Closed
The purpose of this study is to evaluate the safety profile of IDE196 (an investigational drug), in enrolled subjects to find out if it is safe and possibly helpful in patients with certain cancers such as metastatic uveal melanoma, cervical cancer, lung cancer, lung cancer, pancreatic cancer, stomach cancer, bladder cancer, cutaneous melanoma or colorectal…
Condition: Cancer / Kidney Cancer
Investigator: Antonio Fojo, MD, PhD
Status: Closed
Axitinib (AG-013736) is an investigational (experimental) drug that is being studied in patients with metastatic pheochromocytoma/paraganglioma. The main goal of this study is to find out if axitinib is able to stop tumors from growing, or shrink tumors in patients with this type of cancer.
Condition: Endocrine & Metabolic Disease
Investigator: Judith Korner, MD
Status: Closed
The purpose of these studies is to gain an understanding of the mechanisms that promote weight loss and improved glucose control. The ultimate goal is to identify therapeutic pathways for obesity and diabetes as a way to optimize surgical procedures and discover novel non-surgical targets for safe and effective drug therapy. Participants with obesity will…
Condition: Healthy Volunteers
Investigator: Elizabeth Shane, MD
Status: Closed
The goal of this study is to learn whether treatment with a safe, commonly used drug called ATENOLOL prevents bone loss in women after menopause. Who Qualifies? Healthy post-menopausal women who are between the ages of 50 and 75. You may not be eligible if you have certain medical conditions. What's Involved? If you are eligible, you will be assigned…
Condition: Cancer / Breast Cancer
Investigator: Meghna Trivedi, MD
Status: Closed
This study is being done to answer the following question: How does the combination of copanlisib and eribulin compare to eribulin alone to lengthen the time you can live with your metastatic triple-negative breast cancer without your cancer getting worse? We are doing this study because we want to find out if this approach is better or worse than the usual…
Condition: Cancer / Solid Tumors
Investigator: Fabio Iwamoto, MD
Status: Closed
The purpose of the study is to test the following: 1) The safety and tolerability (how you feel when you take the drug) of the study drug, 2) The pharmacokinetics (PK) (how the study drug is absorbed within your body, spread throughout your body, and eliminated from your body) of the study drug, 3) The pharmacodynamics (PD) (how the study drug affects…
Condition: Cancer
Investigator: Benjamin Herzberg, MD
Status: Closed
This study is being done to obtain information on the safety and side effects, good or bad, of two new drug combinations; AMG 510 plus trametinib and AMG 510 plus AMG 404. Subjects will participate in one of two research groups. Group A will receive AMG 510 and trametinib. Research Group B will receive AMG 510 and AMG 404. AMG 510 is an anticancer drug that…